日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1-Coated Gut Bacteria.

免疫球蛋白 A 肾病患者表现出 B 细胞亚群、非常规 T 细胞的异常频率,以及高水平的缺乏半乳糖的 IgA1 包被的肠道细菌

Gentile Micaela, Goerlich Nina, Lo I-Ju, Olson N Eric, McConnell Mark, Pospiech Johannes, Bohnenpoll Tobias, Skroblin Philipp, Radresa Olivier, Andag Uwe, Campbell Kirk N, Meliambro Kristin, Sanchez-Russo Luis, Verlato Alberto, Fiaccadori Enrico, Kim-Schulze Seunghee, Lanau Maria, Fernandez-Lorente M Loreto, Fribourg Miguel, Manrique Joaquin, Cravedi Paolo

Applying population mechanistic modelling to find determinants of chimeric antigen receptor T-cells dynamics in month-one lymphoma patients

应用群体机制模型寻找淋巴瘤患者入院一个月后嵌合抗原受体T细胞动态变化的决定因素

Brown, Liam V; McConnell, Mark; Rosler, Robert; Peiser, Leanne; Schmidt, Brian J; Ratushny, Alexander V; Gaffney, Eamonn A; Coles, Mark C

Correction to: Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies

更正:定量系统药理学模型在阿瓦多米诱导的中性粒细胞减少症研究中的应用,可实现虚拟临床剂量和给药方案探索研究

Abbiati, Roberto A; Pourdehnad, Michael; Carrancio, Soraya; Pierce, Daniel W; Kasibhatla, Shailaja; McConnell, Mark; Trotter, Matthew W B; Loos, Remco; Santini, Cristina C; Ratushny, Alexander V

Analysis of cellular kinetic models suggest that physiologically based model parameters may be inherently, practically unidentifiable

细胞动力学模型分析表明,基于生理学的模型参数可能本质上是无法识别的,实际上也无法识别。

Brown, Liam V; Coles, Mark C; McConnell, Mark; Ratushny, Alexander V; Gaffney, Eamonn A

Quantitative Systems Pharmacology Modeling of Avadomide-Induced Neutropenia Enables Virtual Clinical Dose and Schedule Finding Studies

阿伐多米特诱导中性粒细胞减少症的定量系统药理学建模可实现虚拟临床剂量和给药方案探索研究

Abbiati, Roberto A; Pourdehnad, Michael; Carrancio, Soraya; Pierce, Daniel W; Kasibhatla, Shailaja; McConnell, Mark; Trotter, Matthew W B; Loos, Remco; Santini, Cristina C; Ratushny, Alexander V

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

兴奋性神经元中拓扑异构酶 1 的缺失会导致基因组不稳定和早发性神经退行性

Giulia Fragola, Angela M Mabb, Bonnie Taylor-Blake, Jesse K Niehaus, William D Chronister, Hanqian Mao, Jeremy M Simon, Hong Yuan, Zibo Li, Michael J McConnell, Mark J Zylka

Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials

骨髓微环境对新诊断多发性骨髓瘤患者预后的影响:一项针对全疗程临床试验患者的队列研究

Danziger, Samuel A; McConnell, Mark; Gockley, Jake; Young, Mary H; Rosenthal, Adam; Schmitz, Frank; Reiss, David J; Farmer, Phil; Alapat, Daisy V; Singh, Amrit; Ashby, Cody; Bauer, Michael; Ren, Yan; Smith, Kelsie; Couto, Suzana S; van Rhee, Frits; Davies, Faith; Zangari, Maurizio; Petty, Nathan; Orlowski, Robert Z; Dhodapkar, Madhav V; Copeland, Wilbert B; Fox, Brian; Hoering, Antje; Fitch, Alison; Newhall, Katie; Barlogie, Bart; Trotter, Matthew W B; Hershberg, Robert M; Walker, Brian A; Dervan, Andrew P; Ratushny, Alexander V; Morgan, Gareth J

A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma

胰腺导管腺癌的可推广数据驱动型多细胞模型

Aguilar, Boris; Gibbs, David L; Reiss, David J; McConnell, Mark; Danziger, Samuel A; Dervan, Andrew; Trotter, Matthew; Bassett, Douglas; Hershberg, Robert; Ratushny, Alexander V; Shmulevich, Ilya

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

高度选择性 PTK2 蛋白水解靶向嵌合体以探测粘着斑激酶支架功能

Johannes Popow, Heribert Arnhof, Gerd Bader, Helmut Berger, Alessio Ciulli, David Covini, Christian Dank, Teresa Gmaschitz, Peter Greb, Jale Karolyi-Özguer, Manfred Koegl, Darryl B McConnell, Mark Pearson, Maria Rieger, Joerg Rinnenthal, Vanessa Roessler, Andreas Schrenk, Markus Spina, Steffen Steur

FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation

基于荧光共振能量转移(FRET)的分析揭示了心肌肌钙蛋白T连接区的结构基础,该分析揭示了导致肥厚型心肌病的Δ160E突变的结构基础。

Abdullah, Salwa; Lynn, Melissa L; McConnell, Mark T; Klass, Matthew M; Baldo, Anthony P; Schwartz, Steven D; Tardiff, Jil C