日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

通过多尺度模拟揭示RAS-RAF复合物的动力学和脂质膜耦合

Carpenter, Timothy S; Aydin, Fikret; Neale, Chris; Van, Que N; Zhang, Xiaohua; Bhatia, Harsh; Sidabras, Jason W; Frank, Peter H; Georgouli, Konstantia; Tempkin, Jeremy O B; Casamayor, Violeta Burns; Gulten, Gulcin; Shrestha, Rebika; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moody, Adam; Moon, Joseph Y; Oppelstrup, Tomas; Glosli, James N; Dharuman, Gautham; Wong, Sergio; Liu, Shusen; Hengartner, Nicolas W; López, Cesar A; Nguyen, Kien; Stanley, Christopher B; Stanton, Liam G; Patel, Lara; Reddy, Tyler; Turbyville, Thomas J; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Gnanakaran, Sandrasegaram; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dashboard Knee: Injury Mechanisms, Diagnostic Challenges, and Treatment Outcomes

膝关节损伤:损伤机制、诊断挑战和治疗结果

Sancilio, Christopher; Fada, Laith; Pulido, Julian; Mousad, Albert D; Sorkin, Skyler; Mastroianni, Michael; Jacobs, Greg; Mccormick, Frank

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520,一种首创的直接共价双重抑制剂,可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.

从结构角度深入了解 RAS-PI3Kα 同工型特异性相互作用以及 RAS 在 PI3Kα 激活中的作用

Czyzyk Daniel, Yan Wupeng, Messing Simon, Gillette William, Tsuji Takashi, Yamaguchi Mitsuhiro, Furuzono Shinji, Turner David M, Esposito Dominic, Nissley Dwight V, McCormick Frank, Simanshu Dhirendra K

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击,阻断 KRAS4b 的 C 端加工

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system.

转录组学、蛋白质组学和功能遗传图谱剖析了神经纤维蛋白在周围神经系统中的功能

Vasudevan Harish N, Arang Nadia, Sacconi Nunez Maria, Kennedy Patrick, Payne Emily, Mohabeer Sarah, Chien Julian, Wright Aaron, Sale Matthew J, Krogan Nevan J, Forget Antoine, McCormick Frank

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

Alexander, Patrick; Chan, Albert H; Rabara, Dana; Swain, Monalisa; Larsen, Erik K; Dyba, Marcin; Chertov, Oleg; Ashraf, Mariam; Champagne, Allison; Lin, Ken; Maciag, Anna; Gillette, William K; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Stephen, Andrew G

NMR (1)H, (13)C, and (15)N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation

人类 NRAS 致癌 Q61R 变体在活性 GTP 结合构象下的 NMR (1)H、(13)C 和 (15)N 共振归属

Sharma, Alok K; Tonelli, Marco; Dyba, Marcin; Gillette, William K; Esposito, Dominic; Nissley, Dwight V; McCormick, Frank; Maciag, Anna E

Rare Subscapularis Anterior Leading Edge Tear following Traumatic Posterior Shoulder Dislocation: A Case Report

创伤性肩关节后脱位后罕见肩胛下肌前缘撕裂:病例报告

Sancilio, Christopher; Pulido, Julian; Mousad, Albert; Sorkin, Skyler; Mastroianni, Michael; McCormick, Frank