日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.

AZ14289671 是一种高选择性且能穿透血脑屏障的不可逆 TKI,靶向 EGFRExon20 插入

Swaih Aisha M, Talbot Sara, Savoca Adriana, Thorpe Hannah, Flemington Vikki, Phillips Benjamin, Colclough Nicola, McCoull William, Radeva Veronika, Hargreaves David, Packer Martin J, Felisberto-Rodrigues Catarina, Thomson Clare, Orme Jonathan P, Deane Carly, Smith Aaron, Johnström Peter, Schou Magnus, McWilliams Lisa, Davey Paul, Enget Marianne, O'Neill Daniel, Cosulich Sabina, Floc'h Nicolas

Examining iPSC derived motor neuron variability and genome stability monitoring as a solution

检测iPSC衍生运动神经元变异性和基因组稳定性监测作为一种解决方案

Finbar Gaffey ,David McCoull ,Egle Vaitone ,Erin Hedges ,Christopher Lovejoy ,Zhi Yao ,Paul D Wright ,Richard J Mead ,Will Stebbeds

Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment

MERTK 的药理抑制会诱发体内视网膜变性:多模态成像眼部安全性评估

Gregory Hamm #, Gareth Maglennon #, Beth Williamson, Ruth Macdonald, Ann Doherty, Stewart Jones, Jayne Harris, James Blades, Alexander R Harmer, Peter Barton, Philip B Rawlins, Paul Smith, Jon Winter-Holt, Lindsay McMurray, Julia Johansson, Paul Fitzpatrick, William McCoull, Muireann Coen

Optimization of an Imidazo[1,2- a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

优化咪唑并[1,2- a]吡啶系列以获得具有体内功效的高选择性 I1/2 型双 Mer/Axl 激酶抑制剂

William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood, Nichola L Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Lainé, Nicola Lindsay

Design and optimisation of dendrimer-conjugated Bcl-2/x(L) inhibitor, AZD0466, with improved therapeutic index for cancer therapy

设计和优化树状聚合物偶联的Bcl-2/x(L)抑制剂AZD0466,以提高其在癌症治疗中的治疗指数

Patterson, Claire M; Balachander, Srividya B; Grant, Iain; Pop-Damkov, Petar; Kelly, Brian; McCoull, William; Parker, Jeremy; Giannis, Michael; Hill, Kathryn J; Gibbons, Francis D; Hennessy, Edward J; Kemmitt, Paul; Harmer, Alexander R; Gales, Sonya; Purbrick, Stuart; Redmond, Sean; Skinner, Matthew; Graham, Lorraine; Secrist, J Paul; Schuller, Alwin G; Wen, Shenghua; Adam, Ammar; Reimer, Corinne; Cidado, Justin; Wild, Martin; Gangl, Eric; Fawell, Stephen E; Saeh, Jamal; Davies, Barry R; Owen, David J; Ashford, Marianne B

A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels

利用“靶标类别”筛选鉴定双孔域钾离子(K2P)通道的激活剂

McCoull, David; Ococks, Emma; Large, Jonathan M; Tickle, David C; Mathie, Alistair; Jerman, Jeffrey; Wright, Paul D

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

Mer 酪氨酸激酶中的 A-loop 相互作用产生具有两步机制和长结合停留时间的抑制剂

Alexander Pflug, Marianne Schimpl, J Willem M Nissink, Ross C Overman, Philip B Rawlins, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, William McCoull

Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2

普仑司特是一种新型的双孔结构域钾通道 TREK2 小分子激活剂

Paul D Wright, David McCoull, Yvonne Walsh, Jonathan M Large, Barbara W Hadrys, Egle Gaurilcikaite, Lewis Byrom, Emma L Veale, Jeff Jerman, Alistair Mathie

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

小鼠中特异性激活 GPR120 的急性降血糖作用主要由胰高血糖素样肽 1 驱动

Linda Sundström, Susanna Myhre, Monika Sundqvist, Andrea Ahnmark, William McCoull, Piotr Raubo, Sam D Groombridge, Magnus Polla, Ann-Christin Nyström, Lisbeth Kristensson, Mats Någård, Maria Sörhede Winzell

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors

高激酶选择性双苯胺嘧啶 PAK1 抑制剂的优化

William McCoull, Edward J Hennessy, Kevin Blades, Claudio Chuaqui, James E Dowling, Andrew D Ferguson, Frederick W Goldberg, Nicholas Howe, Christopher R Jones, Paul D Kemmitt, Gillian Lamont, Jeffrey G Varnes, Richard A Ward, Bin Yang