日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells

对 Perturb-seq 在分化人类多能干细胞中的应用进行基准测试和优化

Sivakumar, Sushama; Wang, Yihan; Goetsch, Sean C; Pandit, Vrushali; Wang, Lei; Zhao, Huan; Sundarrajan, Anjana; Armendariz, Daniel; Takeuchi, Chikara; Deng, Minnie; Nzima, Mpathi; Chen, Wei-Chen; Dederich, Ashley E; El Hayek, Lauretta; Gao, Taosha; Gogate, Ashlesha; Kaur, Kiran; Kim, Hyung Bum; McCoy, Melissa K; Niederstrasser, Hanspeter; Oura, Seiya; Pinzon-Arteaga, Carlos A; Sanghvi, Menaka; Schmitz, Daniel A; Yu, Leqian; Zhang, Yanfeng; Zhou, Qinbo; Kraus, W Lee; Xu, Lin; Wu, Jun; Posner, Bruce A; Chahrour, Maria H; Hon, Gary C; Munshi, Nikhil V

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

药物的协同和拮抗作用普遍存在,但并非在急性髓系白血病细胞系中都保守存在。

Kalkan, Fatma Neslihan; Yildiz, Muhammed Sadik; Wood, N Ezgi; Farid, Michael; McCoy, Melissa; Lin, Milo M; Zhang, Chengcheng; Posner, Bruce A; Chung, Stephen S; Toprak, Erdal

A Computational Workflow for Structure-Guided Design of Potent and Selective Kinase Peptide Substrates.

基于结构导向的高效选择性激酶肽底物设计的计算工作流程

Yekeen Abeeb A, Meyer Cynthia J, McCoy Melissa, Posner Bruce, Westover Kenneth D

Select azo compounds post-translationally modulate HTRA1 abundance and activity potentially through interactions at the trimer interface.

某些偶氮化合物可通过与三聚体界面相互作用,在翻译后调节 HTRA1 的丰度和活性

Hulleman John D, Jeon Seungje, Bali Sofia, DiCesare Sophia M, Abbas Ali, Daniel Steffi, Ortega Antonio J, Collier Gracen E, Yang Julian, Bhattacharyaa Archishman, McCoy Melissa K, Joachimiak Lukasz A, Posner Bruce A

GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology

GSK3抑制剂可减少细胞外基质的生成,并预防与年龄相关的黄斑变性样病变。

DiCesare, Sophia M; Ortega, Antonio J; Collier, Gracen E; Daniel, Steffi; Thompson, Krista N; McCoy, Melissa K; Posner, Bruce A; Hulleman, John D

LIMS-Kinase provides sensitive and generalizable label-free in vitro measurement of kinase activity using mass spectrometry

LIMS-Kinase 利用质谱技术,提供了一种灵敏且通用的无标记体外激酶活性测量方法。

Meyer, Cynthia; McCoy, Melissa; Li, Lianbo; Posner, Bruce; Westover, Kenneth D

Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function

小分子介导的胰岛素过度分泌可诱导短暂的内质网应激反应和β细胞功能丧失

Rodrigues-Dos-Santos, Karina; Roy, Gitanjali; Binns, Derk D; Grzemska, Magdalena G; Barella, Luiz F; Armoo, Fiona; McCoy, Melissa K; Huynh, Andy V; Yang, Jonathan Z; Posner, Bruce A; Cobb, Melanie H; Kalwat, Michael A

A systematic review of the relationships among psychosocial factors and coping in adults with type 2 diabetes mellitus

对2型糖尿病成人患者的心理社会因素与应对方式之间关系的系统性综述

McCoy, Melissa A; Theeke, Laurie A

Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways

基于胰岛素启动子驱动的高斯荧光素酶的胰岛素分泌生物传感器检测方法用于发现β细胞葡萄糖感知通路

Kalwat, Michael A; Wichaidit, Chonlarat; Nava Garcia, Alejandra Y; McCoy, Melissa K; McGlynn, Kathleen; Hwang, In Hyun; MacMillan, John B; Posner, Bruce A; Cobb, Melanie H

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

己糖激酶活性是帕金蛋白募集到去极化线粒体所必需的。

McCoy, Melissa K; Kaganovich, Alice; Rudenko, Iakov N; Ding, Jinhui; Cookson, Mark R