日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of SD-965 as a Potent, Selective, and Efficacious STAT3 PROTAC Degrader

发现 SD-965 是一种高效、选择性强且有效的 STAT3 PROTAC 降解剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c03767
Wu, Dimin; Zhou, Haibin; Bai, Longchuan; Acharyya, Ranjan Kumar; Metwally, Hoda; McEachern, Donna; Wang, Mi; Tošović, Jelena; Rej, Rohan Kalyan; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng
JAK/STAT
STAT3
发表日期：2026
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MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration

MD-4251：一种首创的口服MDM2降解剂，单次给药即可诱导肿瘤完全消退

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00809
Acharyya, Ranjan Kumar; Huang, Liyue; Aguilar, Angelo; Hu, Biao; Bai, Longchuan; Metwally, Hoda; McEachern, Donna; Jiang, Wei; Wang, Yu; Li, Qiuxia; Wen, Bo; Sun, Duxin; Wang, Shaomeng
MDM2
肿瘤
肿瘤免疫
发表日期：2025
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Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer

发现 ERD-1233 是一种强效且口服有效的雌激素受体 PROTAC 降解剂，可用于治疗 ER+ 人类乳腺癌

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01521
Acharyya, Ranjan Kumar; Rej, Rohan Kalyan; Hu, Biao; Chen, Zhixiang; Wu, Dimin; Lu, Jianfeng; Metwally, Hoda; McEachern, Donna; Wang, Yu; Jiang, Wei; Bai, Longchuan; Tošović, Jelena; Gersch, Christina L; Xu, Guozhang; Zhang, Weihong; Wu, WenXue; Priestley, E Scott; Sui, Zhihua; Sarkari, Farzad; Wen, Bo; Sun, Duxin; Rae, James M; Wang, Shaomeng
肿瘤
肿瘤免疫
信号转导
乳腺癌
Human
免疫/内分泌
发表日期：2024
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Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

SD-436 的发现：一种强效、高选择性和高效的 STAT3 PROTAC 降解剂，能够实现完全且持久的肿瘤消退

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01946
Xu, Renqi; Zhou, Haibin; Bai, Longchuan; McEachern, Donna; Wu, Dimin; Acharyya, Ranjan Kumar; Wang, Mi; Tošović, Jelena; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Meagher, Jennifer L; Stuckey, Jeanne A; Liu, Cai; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng
JAK/STAT
STAT3
肿瘤
肿瘤免疫
发表日期：2024
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Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia

MD-265 的发现：一种强效的 MDM2 降解剂，可实现肿瘤完全消退并提高白血病小鼠的长期生存率

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01818
Aguilar, Angelo; Yang, Jiuling; Li, Yangbing; McEachern, Donna; Huang, Liyue; Razzouk, Stevenchoukry; Wang, Shaomeng
白血病
MDM2
肿瘤
肿瘤免疫
发表日期：2024
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Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).

发现 ERD-12310A 是一种效力极强且口服有效的雌激素受体 α (ERα) PROTAC 降解剂。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01401
Rej Rohan Kalyan, Hu Biao, Chen Zhixiang, Acharyya Ranjan Kumar, Wu Dimin, Metwally Hoda, McEachern Donna, Wang Yu, Jiang Wei, Bai Longchuan, Nishimura Leticia S, Gersch Christina L, Wang Meilin, Wen Bo, Sun Duxin, Carlson Kathryn, Katzenellenbogen John A, Xu Guozhang, Zhang Weihong, Wu Wenxue, Priestley E Scott, Sui Zhihua, Rae James M, Wang Shaomeng
信号转导
免疫/内分泌
发表日期：2024
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Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.

发现 ARD-2585 是一种效力极强且口服有效的 PROTAC 雄激素受体降解剂，可用于治疗晚期前列腺癌

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c00900
Xiang Weiguo, Zhao Lijie, Han Xin, Qin Chong, Miao Bukeyan, McEachern Donna, Wang Yu, Metwally Hoda, Kirchhoff Paul D, Wang Lu, Matvekas Aleksas, He Miao, Wen Bo, Sun Duxin, Wang Shaomeng
肿瘤
前列腺癌
发表日期：2021
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Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

发现 M-808 是一种高效的共价小分子抑制剂，可抑制 Menin-MLL 相互作用，并具有很强的体内抗肿瘤活性

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.0c00547
Xu Shilin, Aguilar Angelo, Huang Liyue, Xu Tianfeng, Zheng Ke, McEachern Donna, Przybranowski Sally, Foster Caroline, Zawacki Kaitlin, Liu Zhaomin, Chinnaswamy Krishnapriya, Stuckey Jeanne, Wang Shaomeng
肿瘤
肿瘤免疫
发表日期：2020
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Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

基于结构的 CF53 发现是一种强效且口服生物利用度高的溴结构域和末端外 (BET) 溴结构域抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b00483
Zhao Yujun, Zhou Bing, Bai Longchuan, Liu Liu, Yang Chao-Yie, Meagher Jennifer L, Stuckey Jeanne A, McEachern Donna, Przybranowski Sally, Wang Mi, Ran Xu, Aguilar Angelo, Hu Yang, Kampf Jeff W, Li Xiaoqin, Zhao Ting, Li Siwei, Wen Bo, Sun Duxin, Wang Shaomeng
其它
发表日期：2018
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Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study

符合国家SEP-1质量指标及其与脓毒症预后的关联：一项多中心回顾性队列研究

期刊:Critical Care Medicine
影响因子:6
doi:10.1097/CCM.0000000000003261
Rhee, Chanu; Filbin, Michael R; Massaro, Anthony F; Bulger, Amy L; McEachern, Donna; Tobin, Kathleen A; Kitch, Barrett T; Thurlo-Walsh, Bert; Kadar, Aran; Koffman, Alexandra; Pande, Anupam; Hamad, Yasir; Warren, David K; Jones, Travis M; O'Brien, Cara; Anderson, Deverick J; Wang, Rui; Klompas, Michael
炎症/感染
败血症
发表日期：2018
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