日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

单剂量CD137抗体药物偶联物可保护恒河猴同种异体造血干细胞移植受者免受急性移植物抗宿主病(GVHD)的侵害。

Gerdemann, Ulrike; Kimler, Kyle; Warren, Matthew R; McGuckin, Connor; Fleming, Ryan A; D'Ambra, Matthew R; Eran, Alal; Albanese, Alexandre; Chen, Edward; Winschel, Marlana; Cagnin, Lorenzo; Lane, Jennifer; Gorfinkel, Lev; Adams, Bartley; Kwun, Jean; Lanieri, Leanne; Hoban, Megan; Lamothe, Tahirih L; Hyzy, Sharon; Olson, Lisa M; Panoskaltsis-Mortari, Angela; Prockop, Susan E; Blazar, Bruce R; Kean, Leslie S; Tkachev, Victor

B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates

B细胞靶向CAR-T细胞疗法可激活患者和非人灵长类动物体内的CD8+细胞毒性CAR-Neg旁观者T细胞。

Kaminski, James; Fleming, Ryan A; Alvarez-Calderon, Francesca; Winschel, Marlana B; McGuckin, Connor; Ho, Emily E; Eng, Fay; Rui, Xianliang; Keskula, Paula; Cagnin, Lorenzo; Charles, Joanne; Zavistaski, Jillian; Margossian, Steven P; Kapadia, Malika A; Rottman, James B; Lane, Jennifer; Baumeister, Susanne H C; Tkachev, Victor; Shalek, Alex K; Kean, Leslie S; Gerdemann, Ulrike

Human OX40L-CAR-T(regs) target activated antigen-presenting cells and control T cell alloreactivity.

人类 OX40L-CAR-T(regs) 靶向活化的抗原呈递细胞并控制 T 细胞同种异体反应性

Rui Xianliang, Alvarez Calderon Francesca, Wobma Holly, Gerdemann Ulrike, Albanese Alexandre, Cagnin Lorenzo, McGuckin Connor, Michaelis Katherine A, Naqvi Kisa, Blazar Bruce R, Tkachev Victor, Kean Leslie S

Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates

Notch信号通路驱动小鼠和非人灵长类动物的肠道移植物抗宿主病

Tkachev, Victor; Vanderbeck, Ashley; Perkey, Eric; Furlan, Scott N; McGuckin, Connor; Gómez Atria, Daniela; Gerdemann, Ulrike; Rui, Xianliang; Lane, Jennifer; Hunt, Daniel J; Zheng, Hengqi; Colonna, Lucrezia; Hoffman, Michelle; Yu, Alison; Outen, Riley; Kelly, Samantha; Allman, Anneka; Koch, Ute; Radtke, Freddy; Ludewig, Burkhard; Burbach, Brandon; Shimizu, Yoji; Panoskaltsis-Mortari, Angela; Chen, Guoying; Carpenter, Stephen M; Harari, Olivier; Kuhnert, Frank; Thurston, Gavin; Blazar, Bruce R; Kean, Leslie S; Maillard, Ivan

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8(+) T cells drive gastrointestinal acute graft-versus-host disease

时空单细胞分析表明,侵袭性和组织驻留记忆性供体CD8(+) T细胞驱动胃肠道急性移植物抗宿主病。

Tkachev, Victor; Kaminski, James; Potter, E Lake; Furlan, Scott N; Yu, Alison; Hunt, Daniel J; McGuckin, Connor; Zheng, Hengqi; Colonna, Lucrezia; Gerdemann, Ulrike; Carlson, Judith; Hoffman, Michelle; Olvera, Joe; English, Chris; Baldessari, Audrey; Panoskaltsis-Mortari, Angela; Watkins, Benjamin; Qayed, Muna; Suessmuth, Yvonne; Betz, Kayla; Bratrude, Brandi; Langston, Amelia; Horan, John T; Ordovas-Montanes, Jose; Shalek, Alex K; Blazar, Bruce R; Roederer, Mario; Kean, Leslie S

Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform

利用RM-scTCR-Seq平台鉴定和追踪恒河猴体内同种异体反应性T细胞克隆

Gerdemann, Ulrike; Fleming, Ryan A; Kaminski, James; McGuckin, Connor; Rui, Xianliang; Lane, Jennifer F; Keskula, Paula; Cagnin, Lorenzo; Shalek, Alex K; Tkachev, Victor; Kean, Leslie S