日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques.

在恒河猴中诱导产生针对 V2 顶点和融合肽的 HIV-1 中和抗体的疫苗。

Duan Hongying, Nkolola Joseph P, Wang Shuishu, Chaudhari Jayeshbhai, Teng I-Ting, Lavine Christy, Parchment Danealle K, Sellers George S, McKee Krisha, O'Dell Sijy, Choe Misook, Du Haijuan, Zhang Baoshan, Perez Alejandro A Espinosa, Rossler Annika, Lasrado Ninaad, Biju Andrea, Becker Jordan E, Carroll Robin, Carson Audrey S, Henry Amy R, Morano Nicholas C, Mughal Madeeha, Rawi Reda, Roark Ryan S, Schramm Chaim A, Shen Chen-Hsiang, Smith Sarah C, Stephens Tyler, Tsybovsky Yaroslav, Van Wazer David J, Wang Hua, Yang Yongping, Rutten Lucy, Langedijk Johannes P M, Cheng Cheng, Wang Lingshu, Douek Daniel C, Koup Richard A, Mascola John R, Shapiro Lawrence, Zhou Tongqing, Doria-Rose Nicole A, Korber Bette, Seaman Michael S, Pierson Theodore C, Kwong Peter D, Barouch Dan H

Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth

酵母展示揭示了大量突变,这些突变可将融合肽疫苗诱导产生的抗体对 HIV-1 的中和广度提高到 59% 以上

França, Camila T; Pletnev, Sergei; Madan, Bharat; Katsamba, Phinikoula S; McKee, Krisha; Morano, Nicholas C; Zhang, Baoshan; Bahna, Fabiana; Bylund, Tatsiana; Lin, Bob C; Louder, Mark K; Mannepalli, Seetha; Nimrania, Rajani; O'Dell, Sijy; Doria-Rose, Nicole A; Kwong, Peter D; Shapiro, Lawrence; Sheng, Zizhang; Zhou, Tongqing; DeKosky, Brandon J

BRAVE: a highly accurate method for predicting HIV-1 antibody resistance using large language models for proteins

BRAVE:一种利用大型蛋白质语言模型预测 HIV-1 抗体耐药性的高精度方法。

El Anbari, Mohammed; Bylund, Tatsiana; O'Dell, Sijy; Tourtellott, Emily; McKee, Krisha; Schmidt, Stephen D; Mkhize, Nonhlanhla N; Moore, Penny L; Doria-Rose, Nicole; Zhou, Tongqing; Rawi, Reda

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

疫苗诱导恒河猴产生针对V2顶点肽和融合肽的HIV-1中和抗体

Duan, Hongying; Nkolola, Joseph P; Wang, Shuishu; Chaudhari, Jayeshbhai; Teng, I-Ting; Lavine, Christy; Parchment, Danealle K; Sellers, George S; McKee, Krisha; O'Dell, Sijy; Choe, Misook; Du, Haijuan; Zhang, Baoshan; Perez, Alejandro A Espinosa; Rossler, Annika; Lasrado, Ninaad; Biju, Andrea; Becker, Jordan E; Carroll, Robin; Carson, Audrey S; Henry, Amy R; Morano, Nicholas C; Mughal, Madeeha; Rawi, Reda; Roark, Ryan S; Schramm, Chaim A; Shen, Chen-Hsiang; Smith, Sarah C; Stephens, Tyler; Tsybovsky, Yaroslav; Van Wazer, David J; Wang, Hua; Yang, Yongping; Rutten, Lucy; Langedijk, Johannes P M; Cheng, Cheng; Wang, Lingshu; Douek, Daniel C; Koup, Richard A; Mascola, John R; Shapiro, Lawrence; Zhou, Tongqing; Doria-Rose, Nicole A; Korber, Bette; Seaman, Michael S; Pierson, Theodore C; Kwong, Peter D; Barouch, Dan H

Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

在美国,一项首次人体试验(HVTN 136/HPTN 092)研究了抗HIV-1单克隆抗体PGT121.414.LS单独使用以及与VRC07-523LS联合使用时,在美国未感染HIV的成年人中的安全性、耐受性、药代动力学和中和活性。该研究为一项开放标签、随机对照的I期临床试验。

Edupuganti, Srilatha; Hurt, Christopher B; Stephenson, Kathryn E; Huang, Yunda; Paez, Carmen A; Yu, Chenchen; Yen, Catherine; Hanscom, Brett; He, Zonglin; Miner, Maurine D; Gamble, Theresa; Heptinstall, Jack; Seaton, Kelly E; Domin, Elizabeth; Lin, Bob C; McKee, Krisha; Doria-Rose, Nicole; Regenold, Stephanie; Spiegel, Hans; Anderson, Maija; McClosky, Nadia; Zhang, Lily; Piwowar-Manning, Estelle; Ackerman, Margaret E; Pensiero, Michael; Dye, Bonnie J; Landovitz, Raphael J; Mayer, Kenneth; Siegel, Marc; Sobieszczyk, Magdalena; Walsh, Stephen R; Gama, Lucio; Barouch, Dan H; Montefiori, David C; Tomaras, Georgia D

Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.

在融合肽引发的SHIV感染猕猴中,HIV-1具有强效且广泛的中和作用

Wang Hua, Cheng Cheng, Dal Santo James L, Shen Chen-Hsiang, Bylund Tatsiana, Henry Amy R, Howe Colin A, Hwang Juyun, Morano Nicholas C, Morris Daniel J, Pletnev Sergei, Roark Ryan S, Zhou Tongqing, Hansen Bryan T, Hoyt Forrest H, Johnston Timothy S, Wang Shuyi, Zhang Baoshan, Ambrozak David R, Becker Jordan E, Bender Michael F, Changela Anita, Chaudhary Ridhi, Corcoran Martin, Corrigan Angela R, Foulds Kathryn E, Guo Yicheng, Lee Myungjin, Li Yingying, Lin Bob C, Liu Tracy, Louder Mark K, Mandolesi Marco, Mason Rosemarie D, McKee Krisha, Nair Vinod, O'Dell Sijy, Olia Adam S, Ou Li, Pegu Amarendra, Raju Nagarajan, Rawi Reda, Roberts-Torres Jesmine, Sarfo Edward K, Sastry Mallika, Schaub Andrew J, Schmidt Stephen D, Schramm Chaim A, Schwartz Cindi L, Smith Sarah C, Stephens Tyler, Stuckey Jonathan, Teng I-Ting, Todd John-Paul, Tsybovsky Yaroslav, Van Wazer David J, Wang Shuishu, Doria-Rose Nicole A, Fischer Elizabeth R, Georgiev Ivelin S, Karlsson Hedestam Gunilla B, Sheng Zizhang, Woodward Ruth A, Douek Daniel C, Koup Richard A, Pierson Theodore C, Shapiro Lawrence, Shaw George M, Mascola John R, Kwong Peter D

Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1

超强效广谱中和人-羊驼双特异性抗体,可对抗 HIV-1

Xu, Jianliang; Zhou, Tongqing; McKee, Krisha; Zhang, Baoshan; Liu, Cuiping; Nazzari, Alexandra F; Pegu, Amarendra; Shen, Chen-Hsiang; Becker, Jordan E; Bender, Michael F; Chan, Payton; Changela, Anita; Chaudhary, Ridhi; Chen, Xuejun; Einav, Tal; Kwon, Young Do; Lin, Bob C; Louder, Mark K; Merriam, Jonah S; Morano, Nicholas C; O'Dell, Sijy; Olia, Adam S; Rawi, Reda; Roark, Ryan S; Stephens, Tyler; Teng, I-Ting; Tourtellott-Fogt, Emily; Wang, Shuishu; Yang, Eun Sung; Shapiro, Lawrence; Tsybovsky, Yaroslav; Doria-Rose, Nicole A; Casellas, Rafael; Kwong, Peter D

Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design

通过计算机模拟设计提高V2-apex抗体对HIV-1的中和广度和效力

Holt, Graham T; Gorman, Jason; Wang, Siyu; Lowegard, Anna U; Zhang, Baoshan; Liu, Tracy; Lin, Bob C; Louder, Mark K; Frenkel, Marcel S; McKee, Krisha; O'Dell, Sijy; Rawi, Reda; Shen, Chen-Hsiang; Doria-Rose, Nicole A; Kwong, Peter D; Donald, Bruce R

Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization

多种小鼠疫苗接种揭示了靶向融合肽的不同抗体类别以及肽长度的变化如何提高HIV中和能力

Sastry, Mallika; Changela, Anita; Gorman, Jason; Xu, Kai; Chuang, Gwo-Yu; Shen, Chen-Hsiang; Cheng, Cheng; Geng, Hui; O'Dell, Sijy; Ou, Li; Rawi, Reda; Reveiz, Mateo; Stewart-Jones, Guillaume B E; Wang, Shuishu; Zhang, Baoshan; Zhou, Tongqing; Biju, Andrea; Chambers, Michael; Chen, Xuejun; Corrigan, Angela R; Lin, Bob C; Louder, Mark K; McKee, Krisha; Nazzari, Alexandra F; Olia, Adam S; Parchment, Danealle K; Sarfo, Edward K; Stephens, Tyler; Stuckey, Jonathan; Tsybovsky, Yaroslav; Verardi, Raffaello; Wang, Yiran; Zheng, Cheng-Yan; Chen, Yuling; Doria-Rose, Nicole A; McDermott, Adrian B; Mascola, John R; Kwong, Peter D

Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life

对 HIV-1 中和抗体 CAP256V2LS 进行工程改造,以提高其可生产性和延长半衰期

Zhang, Baoshan; Gollapudi, Deepika; Gorman, Jason; O'Dell, Sijy; Damron, Leland F; McKee, Krisha; Asokan, Mangaiarkarasi; Yang, Eun Sung; Pegu, Amarendra; Lin, Bob C; Chao, Cara W; Chen, Xuejun; Gama, Lucio; Ivleva, Vera B; Law, William H; Liu, Cuiping; Louder, Mark K; Schmidt, Stephen D; Shen, Chen-Hsiang; Shi, Wei; Stein, Judith A; Seaman, Michael S; McDermott, Adrian B; Carlton, Kevin; Mascola, John R; Kwong, Peter D; Lei, Q Paula; Doria-Rose, Nicole A