日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy

IFN-γ驱动的Th1细胞分化相对于Th17细胞分化的偏倚是CAR-T疗法中细胞因子释放综合征（CRS）和中性粒细胞减少症的根本原因。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI194631
Goala, Payal; Zhang, Yongliang; Beatty, Nolan; Pavy, Allan; McSain, Shannon; Sailer, Cooper; Tariq, Muhammad Junaid; Hamid, Showkat; Cortes Gomez, Eduardo; Wang, Jianmin; Massillon, Duna; Ilecki, Maxwell; Boucher, Justin C; Savid-Frontera, Constanza; Lee, Sae Bom; Kotani, Hiroshi; Stone, Meredith L; Jain, Michael D; Davila, Marco L
中性粒细胞
粒细胞
IFN-γ
细胞生物学
免疫/内分泌
发表日期：2026
文献求助 收藏

Cre-dependent gene expression enables thymic development of autoreactive tumor-associated antigen targeting CAR-T cells

Cre依赖性基因表达促进胸腺中自身反应性肿瘤相关抗原靶向CAR-T细胞的发育

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2025.12.047
Bariana, Manpreet; McGuire, Michael; Tuckett, Andrea; Cassella, Elena; Anand, Sidharth; Anuncio, Shaina A; Mina, Sara; Avtalion, Sharoni; Lloren, Megan A; Bogert, Nicolai; Konstandin, Mathias; Boucher, Justin; Beatty, Nolan; McSain, Shannon; Hu, Wei; Xue, Hai-Hui; Davila, Marco L; Zakrzewski, Johannes L
T细胞
T细胞
发育与干细胞
免疫/内分泌
肿瘤
细胞生物学
肿瘤免疫
发表日期：2026
文献求助 收藏

CD28 co-stimulatory domain enhances efficacy of CER T cell therapy compared to 4-1BB in an ovarian cancer mouse model

在卵巢癌小鼠模型中，与4-1BB相比，CD28共刺激结构域可增强CER T细胞疗法的疗效。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-026-43225-0
Beatty, Nolan J; Ma, Min; Goala, Payal; McSain, Shannon; Lee, Sae Bom; Boucher, Justin C; Stone, Meredith L; Kang, Yun Pyo; Cortes-Gomez, Eduardo; Wang, Jianmin; Qu, Jun; Davila, Marco L
肿瘤
T细胞
肿瘤免疫
卵巢癌
T细胞
细胞生物学
CD2
CD28
免疫/内分泌
发表日期：2026
文献求助 收藏

Behavioral economics of polysubstance use: The role of orexin-1 receptors in nicotine-induced augmentation of synthetic opioid consumption

多物质滥用行为经济学：食欲素-1受体在尼古丁诱导的合成阿片类药物消费增加中的作用

期刊:Neuropharmacology
影响因子:4.6
doi:10.1016/j.neuropharm.2025.110467
Honeycutt, Sarah C; Gilles-Thomas, Elizabeth A; Lichte, David D; McSain, Shannon L; Mukherjee, Ashmita; Loney, Gregory C
信号转导
发表日期：2025
文献求助 收藏

CAR T cell-driven induction of iNOS in tumor-associated macrophages promotes CAR T cell resistance in B cell lymphoma

CAR T 细胞驱动的肿瘤相关巨噬细胞中 iNOS 的诱导促进 B 细胞淋巴瘤的 CAR T 细胞耐药性

期刊:
影响因子:
doi:10.21203/rs.3.rs-3481746/v1
Davila, Marco; Lee, Sae Bom; Kang, Yun Pyo; Boucher, Justin; Mandula, Jay; Roselli, Emiliano; Chang, Darwin; Jimenez, Rachel; Kotani, Hiroshi; Reid, Kayla; Vazquez-Martinez, Julio; Beatty, Nolan; Goala, Payal; Sierra-Mondragon, Rosa; Liu, Min; Koomen, John; Nguyen, Jonathan; Hussaini, Mohammad; Shaw, Timothy; Wang, Xuefeng; Faramand, Rawan; Jain, Michael; Locke, Frederick; Rodriguez, Paulo; Sailer, Cooper; McSain, Shannon; Hamid, Showkat; Tariq, Muhammad; Wang, Jianmin; Abraham-Miranda, Julieta
巨噬细胞
肿瘤
T细胞
肿瘤免疫
巨噬细胞
淋巴瘤
iNOS
细胞生物学
免疫/内分泌
发表日期：2025
文献求助 收藏

JAK2/mTOR inhibition fails to prevent acute GVHD despite reduced Th1/Th17 cells: final phase 2 trial results

尽管Th1/Th17细胞减少，JAK2/mTOR抑制剂仍未能预防急性GVHD：2期临床试验最终结果

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2024024789
Pidala, Joseph; Holtan, Shernan G; Walton, Kelly; Kim, Jongphil; Cao, Biwei; Elmariah, Hany; Mishra, Asmita; Bejanyan, Nelli; Nishihori, Taiga; Khimani, Farhad; Perez, Lia; Faramand, Rawan G; Davila, Marco L; McSain, Shannon; Pleskow, Jordan; Baron, Jeffrey; Anasetti, Claudio; Moran Segura, Carlos; Weisdorf, Daniel J; Blazar, Bruce R; Miller, Jeffrey S; Bachanova, Veronika; El Jurdi, Najla; Betts, Brian C
JAK/STAT
细胞生物学
mTOR
JAK2
发表日期：2024
文献求助 收藏

Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures

双侧岛叶皮质损伤会降低巴甫洛夫条件反射实验中对急性乙醇中毒不良后果的敏感性。

期刊:ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子:3
doi:10.1111/acer.15383
Mukherjee, Ashmita; Gilles-Thomas, Elizabeth A; Kwok, Hay Young; Shorter, Cerissa E; Sontate, Kajol V; McSain, Shannon L; Honeycutt, Sarah C; Loney, Gregory C
发表日期：2024
文献求助 收藏

Nicotine limits avoidance conditioning with opioids without interfering with the ability to discriminate an opioid-interoceptive state

尼古丁可限制阿片类药物引起的回避条件反射，且不干扰对阿片类药物内感受状态的辨别能力。

期刊:Pharmacology Biochemistry and Behavior
影响因子:2.5
doi:10.1016/j.pbb.2023.173604
Mukherjee, A; Gilles-Thomas, E A; McSain, S L; Paladino, M S; Sontate, K V; Ezenwa, K B; Honeycutt, S C; Loney, G C
发表日期：2023
文献求助 收藏