日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preventing premature deaths through polygenic risk scores

通过多基因风险评分预防过早死亡

Chuong, Melisa; Thompson, Deborah; Weale, Michael E; Riveros-Mckay, Fernando; Samani, Nilesh J; Wells, Daniel; Plagnol, Vincent; McVean, Gil; Ashley, Euan A; Donnelly, Peter; Harrison, Seamus; O'Sullivan, Jack W

Protocol for using treeLFA to infer multimorbidity patterns in the form of disease topics from diagnosis data in biobanks

利用 treeLFA 从生物样本库的诊断数据中推断以疾病主题形式存在的多种疾病模式的方案

Zhang, Yidong; Jiang, Xilin; McVean, Gil; Lunter, Gerton

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

暴露累积驱动与年龄相关的疾病结构和多基因风险评分

Jiang, Xilin; Price, Alkes L; Danesh, John; McVean, Gil; Inouye, Michael; Urbut, Sarah; Durvasula, Arun

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

高分辨率非洲HLA资源揭示了HLA-DRB1表达对疫苗反应的影响

Mentzer, Alexander J; Dilthey, Alexander T; Pollard, Martin; Gurdasani, Deepti; Karakoc, Emre; Carstensen, Tommy; Muhwezi, Allan; Cutland, Clare; Diarra, Amidou; da Silva Antunes, Ricardo; Paul, Sinu; Smits, Gaby; Wareing, Susan; Kim, HwaRan; Pomilla, Cristina; Chong, Amanda Y; Brandt, Debora Y C; Nielsen, Rasmus; Neaves, Samuel; Timpson, Nicolas; Crinklaw, Austin; Lindestam Arlehamn, Cecilia S; Rautanen, Anna; Kizito, Dennison; Parks, Tom; Auckland, Kathryn; Elliott, Kate E; Mills, Tara; Ewer, Katie; Edwards, Nick; Fatumo, Segun; Webb, Emily; Peacock, Sarah; Jeffery, Katie; van der Klis, Fiona R M; Kaleebu, Pontiano; Vijayanand, Pandurangan; Peters, Bjorn; Sette, Alessandro; Cereb, Nezih; Sirima, Sodiomon; Madhi, Shabir A; Elliott, Alison M; McVean, Gil; Hill, Adrian V S; Sandhu, Manjinder S

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy

英国生物银行抗体分析检测到的一种常见NFKB1变异体可预测感染和过敏风险

Chong, Amanda Y; Brenner, Nicole; Jimenez-Kaufmann, Andres; Cortes, Adrian; Hill, Michael; Littlejohns, Thomas J; Gilchrist, James J; Fairfax, Benjamin P; Knight, Julian C; Hodel, Flavia; Fellay, Jacques; McVean, Gil; Moreno-Estrada, Andres; Waterboer, Tim; Hill, Adrian V S; Mentzer, Alexander J

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release

对英国生物银行多基因风险评分(PRS)版本的性能和特性进行系统评估

Thompson, Deborah J; Wells, Daniel; Selzam, Saskia; Peneva, Iliana; Moore, Rachel; Sharp, Kevin; Tarran, William A; Beard, Edward J; Riveros-Mckay, Fernando; Giner-Delgado, Carla; Palmer, Duncan; Seth, Priyanka; Harrison, James; Futema, Marta; McVean, Gil; Plagnol, Vincent; Donnelly, Peter; Weale, Michael E

Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk

英国生物银行中基于年龄的合并症主题建模识别出具有不同遗传风险的疾病亚型

Jiang, Xilin; Zhang, Martin Jinye; Zhang, Yidong; Durvasula, Arun; Inouye, Michael; Holmes, Chris; Price, Alkes L; McVean, Gil

Optimal strategies for learning multi-ancestry polygenic scores vary across traits

学习多祖源多基因评分的最佳策略因性状而异。

Lehmann, Brieuc; Mackintosh, Maxine; McVean, Gil; Holmes, Chris

Topic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank

主题建模识别出英国生物银行中与多种疾病相关的新基因位点

Zhang, Yidong; Jiang, Xilin; Mentzer, Alexander J; McVean, Gil; Lunter, Gerton

A unified genealogy of modern and ancient genomes

现代和古代基因组的统一谱系

Wohns, Anthony Wilder; Wong, Yan; Jeffery, Ben; Akbari, Ali; Mallick, Swapan; Pinhasi, Ron; Patterson, Nick; Reich, David; Kelleher, Jerome; McVean, Gil