Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade.
亲脂性他汀类药物通过消耗 GPX4 促进铁死亡,使癌细胞对免疫检查点阻断疗法更加敏感。
期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-25-0667
Talty Ronan, Brooks Veronica T, McGeary Meaghan K, Milette Simon, Zheng Sijin, Flem-Karlsen Karine, Daniels Andrew, Deshmukh Maya, Park Koonam, Caraccio Will, Yan Hong, Echeandia-Francis Caroline, McNamara Madeline, Hong Suyeon, Kirwin David S, Olino Kelly, Johnson Caroline H, Bosenberg Marcus, Micevic Goran, Roy Simon F
Checkpoint
肿瘤
肿瘤免疫
铁死亡
GPX4
细胞生物学
免疫/内分泌