Meagher Jennifer L相关文献与解析，生知库

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

SD-436 的发现：一种强效、高选择性和高效的 STAT3 PROTAC 降解剂，能够实现完全且持久的肿瘤消退

doi:10.1021/acs.jmedchem.4c01946

Xu, Renqi; Zhou, Haibin; Bai, Longchuan; McEachern, Donna; Wu, Dimin; Acharyya, Ranjan Kumar; Wang, Mi; Tošović, Jelena; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Meagher, Jennifer L; Stuckey, Jeanne A; Liu, Cai; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

锌指抗病毒蛋白与RNA复合物的结构揭示了其选择性靶向富含CG序列的病毒序列的机制。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1913232116

Meagher, Jennifer L; Takata, Matthew; Gonçalves-Carneiro, Daniel; Keane, Sarah C; Rebendenne, Antoine; Ong, Heley; Orr, Victoria K; MacDonald, Margaret R; Stuckey, Jeanne A; Bieniasz, Paul D; Smith, Janet L

微生物学

发表日期：2019

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Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H

异质核糖核蛋白H准RNA识别基序之间的连接子编码的差异构象动力学

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.8b05366

Penumutchu, Srinivasa R; Chiu, Liang-Yuan; Meagher, Jennifer L; Hansen, Alexandar L; Stuckey, Jeanne A; Tolbert, Blanton S

发表日期：2018

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Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

基于结构的 CF53 发现是一种强效且口服生物利用度高的溴结构域和末端外 (BET) 溴结构域抑制剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.8b00483

Zhao Yujun, Zhou Bing, Bai Longchuan, Liu Liu, Yang Chao-Yie, Meagher Jennifer L, Stuckey Jeanne A, McEachern Donna, Przybranowski Sally, Wang Mi, Ran Xu, Aguilar Angelo, Hu Yang, Kampf Jeff W, Li Xiaoqin, Zhao Ting, Li Siwei, Wen Bo, Sun Duxin, Wang Shaomeng

其它

发表日期：2018

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Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

酰基蛋白硫酯酶 1 和 2 (APT1 和 APT2) 同工酶选择性抑制的分子机制

期刊:ACS Chemical Biology

影响因子:3.8

doi:10.1021/acschembio.6b00720

Won, Sang Joon; Davda, Dahvid; Labby, Kristin J; Hwang, Sin Ye; Pricer, Rachel; Majmudar, Jaimeen D; Armacost, Kira A; Rodriguez, Laura A; Rodriguez, Christina L; Chong, Fei San; Torossian, Kristopher A; Palakurthi, Jasmine; Hur, Edward S; Meagher, Jennifer L; Brooks, Charles L 3rd; Stuckey, Jeanne A; Martin, Brent R

发表日期：2016

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Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity

达沙替尼的构象选择性类似物揭示了激酶抑制剂的结合和选择性

期刊:ACS Chemical Biology

影响因子:3.8

doi:10.1021/acschembio.5b01018

Kwarcinski, Frank E; Brandvold, Kristoffer R; Phadke, Sameer; Beleh, Omar M; Johnson, Taylor K; Meagher, Jennifer L; Seeliger, Markus A; Stuckey, Jeanne A; Soellner, Matthew B

信号转导

发表日期：2016

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Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity

通过解耦促有丝分裂活性和抗病毒活性来构建治疗性凝集素

期刊:Cell

影响因子:42.5

doi:10.1016/j.cell.2015.09.056

Swanson, Michael D; Boudreaux, Daniel M; Salmon, Loïc; Chugh, Jeetender; Winter, Harry C; Meagher, Jennifer L; André, Sabine; Murphy, Paul V; Oscarson, Stefan; Roy, René; King, Steven; Kaplan, Mark H; Goldstein, Irwin J; Tarbet, E Bart; Hurst, Brett L; Smee, Donald F; de la Fuente, Cynthia; Hoffmann, Hans-Heinrich; Xue, Yi; Rice, Charles M; Schols, Dominique; Garcia, J Victor; Stuckey, Jeanne A; Gabius, Hans-Joachim; Al-Hashimi, Hashim M; Markovitz, David M

微生物学

发表日期：2015

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The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein

hnRNP A1 UP1结构域与RNA结合的首个晶体结构揭示了这种古老的RNA结合蛋白的新面貌

期刊:Journal of Molecular Biology

影响因子:4.5

doi:10.1016/j.jmb.2015.05.009

Morgan, Christopher E; Meagher, Jennifer L; Levengood, Jeffrey D; Delproposto, James; Rollins, Carrie; Stuckey, Jeanne A; Tolbert, Blanton S

hnRNP A1

发表日期：2015

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Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis

脂质A生物合成中酰基转移酶识别肽RJPXD33的结构基础

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.M114.564278

Jenkins, Ronald J; Heslip, Kyle A; Meagher, Jennifer L; Stuckey, Jeanne A; Dotson, Garry D

发表日期：2014

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A minimal complex of KHNYN and zinc-finger antiviral protein binds and degrades single-stranded RNA

KHNYN 与锌指抗病毒蛋白形成的最小复合物能够结合并降解单链 RNA。

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression

SD-436 的发现：一种强效、高选择性和高效的 STAT3 PROTAC 降解剂，能够实现完全且持久的肿瘤消退

Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences

锌指抗病毒蛋白与RNA复合物的结构揭示了其选择性靶向富含CG序列的病毒序列的机制。

Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H

异质核糖核蛋白H准RNA识别基序之间的连接子编码的差异构象动力学

Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.

基于结构的 CF53 发现是一种强效且口服生物利用度高的溴结构域和末端外 (BET) 溴结构域抑制剂

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)

酰基蛋白硫酯酶 1 和 2 (APT1 和 APT2) 同工酶选择性抑制的分子机制

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity

达沙替尼的构象选择性类似物揭示了激酶抑制剂的结合和选择性

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity

通过解耦促有丝分裂活性和抗病毒活性来构建治疗性凝集素

The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein

hnRNP A1 UP1结构域与RNA结合的首个晶体结构揭示了这种古老的RNA结合蛋白的新面貌

Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis

脂质A生物合成中酰基转移酶识别肽RJPXD33的结构基础