日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expression of Concern for Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

肥胖和糖尿病患者体内循环淀粉样蛋白浓度升高会促进血管功能障碍,对此表示关注。

Meakin, Paul J; Coull, Bethany M; Tuharska, Zofia; McCaffery, Christopher; Akoumianakis, Ioannis; Antoniades, Charalambos; Brown, Jane; Griffin, Kathryn J; Platt, Fiona; Ozber, Claire H; Yuldasheva, Nadira Y; Makava, Natallia; Skromna, Anna; Prescott, Alan; McNeilly, Alison D; Siddiqui, Moneeza; Palmer, Colin Na; Khan, Faisel; Ashford, Michael Lj

Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4).

转化生长因子β(TGF-β)通过氯离子细胞内通道4(CLIC4)诱导系统性硬化症角质形成细胞中的1型干扰素信号传导

Wasson Christopher W, Dibb Sophie L, Caballero-Ruiz Begoña, Bamigbola Ifeoluwa E, Di Donato Stefano, Madourie-Clavane Eva M, Wells Rebecca, Kakkar Vishal, De Lorenzis Enrico, Bryon Jessica, Derrett-Smith Emma, Denton Christopher P, El-Sherbiny Yasser, Meakin Paul J, Ross Rebecca L, Del Galdo Francesco

The diabetic myocardial transcriptome reveals Erbb3 and Hspa2 as a novel biomarkers of incident heart failure

糖尿病心肌转录组分析揭示 Erbb3 和 Hspa2 是新发心力衰竭的新型生物标志物

Conning-Rowland, Marcella S; Giannoudi, Marilena; Drozd, Michael; Brown, Oliver I; Yuldasheva, Nadira Y; Cheng, Chew W; Meakin, Paul J; Straw, Sam; Gierula, John; Ajjan, Ramzi A; Kearney, Mark T; Levelt, Eylem; Roberts, Lee D; Griffin, Kathryn J; Cubbon, Richard M

BACE1: More than just a β-secretase

BACE1:不仅仅是一种β-分泌酶

Taylor, Hannah A; Przemylska, Lena; Clavane, Eva M; Meakin, Paul J

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

轻度氧化应激诱导星形胶质细胞中Nrf2的非经典Keap1非依赖性激活

Al-Mubarak, Bashayer R; Bell, Karen F S; Chowdhry, Sudhir; Meakin, Paul J; Baxter, Paul S; McKay, Sean; Dando, Owen; Ashford, Michael L J; Gazaryan, Irina; Hayes, John D; Hardingham, Giles E

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

小血管、痴呆和慢性疾病——分子机制和病理生理学

Horsburgh, Karen; Wardlaw, Joanna M; van Agtmael, Tom; Allan, Stuart M; Ashford, Mike L J; Bath, Philip M; Brown, Rosalind; Berwick, Jason; Cader, M Zameel; Carare, Roxana O; Davis, John B; Duncombe, Jessica; Farr, Tracy D; Fowler, Jill H; Goense, Jozien; Granata, Alessandra; Hall, Catherine N; Hainsworth, Atticus H; Harvey, Adam; Hawkes, Cheryl A; Joutel, Anne; Kalaria, Rajesh N; Kehoe, Patrick G; Lawrence, Catherine B; Lockhart, Andy; Love, Seth; Macleod, Malcolm R; Macrae, I Mhairi; Markus, Hugh S; McCabe, Chris; McColl, Barry W; Meakin, Paul J; Miller, Alyson; Nedergaard, Maiken; O'Sullivan, Michael; Quinn, Terry J; Rajani, Rikesh; Saksida, Lisa M; Smith, Colin; Smith, Kenneth J; Touyz, Rhian M; Trueman, Rebecca C; Wang, Tao; Williams, Anna; Williams, Steven C R; Work, Lorraine M

Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice

Bace1依赖的淀粉样蛋白加工调控肥胖小鼠下丘脑瘦素敏感性

Meakin, Paul J; Jalicy, Susan M; Montagut, Gemma; Allsop, David J P; Cavellini, Daniella L; Irvine, Stuart W; McGinley, Christopher; Liddell, Mary K; McNeilly, Alison D; Parmionova, Karolina; Liu, Yu-Ru; Bailey, Charlotte L S; Dale, J Kim; Heisler, Lora K; McCrimmon, Rory J; Ashford, Michael L J

Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

缺乏β2整合素功能的小鼠尽管存在胰岛素抵抗、中性粒细胞浸润和炎症,仍保持葡萄糖耐受性。

Meakin, Paul J; Morrison, Vicky L; Sneddon, Claire C; Savinko, Terhi; Uotila, Liisa; Jalicy, Susan M; Gabriel, Jennie L; Kang, Li; Ashford, Michael L J; Fagerholm, Susanna C

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance

Nrf2基因敲除小鼠在摄入高脂饮食后易患脂肪性肝炎和肝硬化,这与氧化应激、未折叠蛋白反应紊乱以及代谢酶表达异常有关,但与胰岛素抵抗无关。

Meakin, Paul J; Chowdhry, Sudhir; Sharma, Ritu S; Ashford, Fiona B; Walsh, Shaun V; McCrimmon, Rory J; Dinkova-Kostova, Albena T; Dillon, John F; Hayes, John D; Ashford, Michael L J

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

降低 BACE1 可减轻小鼠体重,防止饮食引起的肥胖,并增强胰岛素敏感性

Meakin Paul J, Harper Alex J, Hamilton D Lee, Gallagher Jennifer, McNeilly Alison D, Burgess Laura A, Vaanholt Lobke M, Bannon Kirsten A, Latcham Judy, Hussain Ishrut, Speakman John R, Howlett David R, Ashford Michael L J