日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.

白血病中发现的 SETD2 L1609P 突变会破坏甲基转移酶活性,降低组蛋白 H3K36 三甲基化。

Michail Christina, Berthelet Jérémy, Mechaly Ariel E, Bui Linh-Chi, Yang Haopeng, Cai Duo, Al Mahi Amira, Xie Aowei, Bisio Valeria, Sirri Valentina, Dupret Jean-Marie, Guidez Fabien, Xu Ximing, Joly Nicolas, Regad Leslie, Viguier Mireille, Deshayes Frédérique, Dulphy Nicolas, Green Michael R, Haouz Ahmed, Rodrigues Lima Fernando

Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

CREBBP突变淋巴瘤中CD40反应性增强子激活减弱可通过强制CD4 T细胞参与来恢复。

Yang, Haopeng; Zhang, Wenchao; Ravanmehr, Vida; Cui, Guiling; Bowman, Kevin; Chen, Ruidong; Henderson, Jared M; Lockman, Shyanne; Rojas, Estela; Wilson, Ashley; Parsons, Sydney; Mechaly, Ariel; Regad, Leslie; Haouz, Ahmed; Flowers, Christopher R; Neelapu, Sattva; Nastoupil, Loretta; Davis, R Eric; Deng, Qing; Rodrigues-Lima, Fernando; Green, Michael R

Ancestral [Fe-S] biogenesis system SMS has a unique mechanism of cluster assembly and sulfur utilization

祖先[Fe-S]生物合成系统SMS具有独特的簇组装和硫利用机制

Dussouchaud, Macha; Martinez-Carranza, Markel; Garcia, Pierre-Simon; Clémancey, Martin; Blondin, Geneviève; Betton, Jean Michel; Haouz, Ahmed; Gribaldo, Simonetta; Ollagnier de Choudens, Sandrine; Sauguet, Ludovic; Mechaly, Ariel; Barras, Frédéric

Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance

揭示辅助肽去甲酰酶在细菌适应和耐药性中的普遍性和多重作用

Lambérioux, Morgan; Ducos-Galand, Magaly; Kaminski, Pierre-Alexandre; Littner, Eloi; Betton, Jean-Michel; Mechaly, Ariel; Haouz, Ahmed; Mazel, Didier

HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2

基于HTRF的靶向SARS-CoV-2 E蛋白与ZO-1 PDZ2相互作用的小分子鉴定

Alvarez, Flavio; Larrous, Florence; Mechaly, Ariel; Bardiaux, Benjamin; Goor, Quentin; Haouz, Ahmed; Séon-Méniel, Blandine; de Sousa, Rodolphe Alves; Bourg, Stéphane; Desmaële, Didier; Figadère, Bruno; Wolff, Nicolas; Munier-Lehmann, Hélène; Caillet-Saguy, Célia

Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase.

CREB结合蛋白(CREBBP)作为组蛋白丙酰转移酶的结构和功能表征

Cui Guiling, Ley Marie, Mechaly Ariel E, Bui Linh-Chi, Michail Christina, Berthelet Jérémy, Dairou Julien, Yang Haopeng, Chevreux Guillaume, Moroy Gautier, Green Michael R, Haouz Ahmed, Rodrigues Lima Fernando

FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia

FLT3 信号抑制可消除阿片类药物耐受性和痛觉过敏,同时保留镇痛作用

Antoine Jouvenel #, Adrien Tassou #, Maxime Thouaye #, Jérôme Ruel, Myriam Antri, Jean-Philippe Leyris, Aurore Giraudin, Sylvie Mallié, Chamroeum Sar, Lucie Diouloufet, Corinne Sonrier, François Daubeuf, Juliette Bertin, Stacy Alves, Stéphanie Ventéo, Nelly Frossard, Patrick Carroll, Ilana Mechaly, 

Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms

与纳米抗体复合的 IV 型菌毛的低温电子显微镜结构揭示了免疫逃逸机制

David Fernandez-Martinez #, Youxin Kong #, Sylvie Goussard, Agustin Zavala, Pauline Gastineau, Martial Rey, Gabriel Ayme, Julia Chamot-Rooke, Pierre Lafaye, Matthijn Vos, Ariel Mechaly, Guillaume Duménil

Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake

吨马达构象转换和肽聚糖在细菌营养吸收中的作用

Maximilian Zinke, Maylis Lejeune, Ariel Mechaly, Benjamin Bardiaux, Ivo Gomperts Boneca, Philippe Delepelaire, Nadia Izadi-Pruneyre

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase

含三唑的结核分枝杆菌DNA旋转酶抑制剂的分子机制

Antoine Gedeon, Emilie Yab, Aurelia Dinut, Elodie Sadowski, Estelle Capton, Aurore Dreneau, Julienne Petit, Bruna Gioia, Catherine Piveteau, Kamel Djaout, Estelle Lecat, Anne Marie Wehenkel, Francesca Gubellini, Ariel Mechaly, Pedro M Alzari, Benoît Deprez, Alain Baulard, Alexandra Aubry, Nicolas Wi