日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM structures of NHEJ assemblies with nucleosomes

核小体参与的NHEJ组装体的冷冻电镜结构

Hall, Chloe; Frit, Philippe; Kefala-Stavridi, Antonia; Pelletier, Amandine; Hardwick, Steven W; Amin, Himani; Bilyard, Matthew K; Maia De Oliviera, Taiana; Tariq, Ammarah; Zahid, Sayma; Chirgadze, Dimitri Y; Balasubramanian, Shankar; Meek, Katheryn; Ropars, Virginie; Charbonnier, Jean-Baptiste; Modesti, Mauro; Calsou, Patrick; Britton, Sébastien; Blundell, Tom L; Schalch, Thomas; Chaplin, Amanda K

Targeting Artemis Sensitizes B Cells to Topoisomerase 2 Poisons by Disrupting DNA-PKcs-Dependent Repair

靶向 Artemis 会通过破坏 DNA-PKcs 依赖性修复,使 B 细胞对拓扑异构酶 2 毒物更加敏感。

Folkerts, Melissa L; Hom, Cameron; Nguyen, Angie; Shen, Kaiyuan V; Rangel, Valeria; Ortega, Pedro; Buisson, Rémi; Masri, Selma; Adachi, Noritaka; Meek, Katheryn; Pannunzio, Nicholas R

Ku limits aberrant mRNA splicing promoted by intronic antisense Alu elements.

Ku 限制由内含子反义 Alu 元件促进的异常 mRNA 剪接。

Pascarella Giovanni, Mikhova Mariia, Parkhi Gargi, Godfrey Jared, Heyza Joshua, Janovič Tomáš, Olive Andrew, Carninci Piero, Schmidt Jens C, Meek Katheryn

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells.

单分子成像揭示了活细胞中非同源末端连接的动力学

Mikhova Mariia, Goff Noah J, Janovič Tomáš, Heyza Joshua R, Meek Katheryn, Schmidt Jens C

DNA-PK: A synopsis beyond synapsis

DNA-PK:超越突触的概要

Goff, Noah J; Mikhova, Mariia; Schmidt, Jens C; Meek, Katheryn

Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals

与其他NHEJ因子相比,DNA-PK蛋白和RNA水平在所有高等灵长类动物中均显著升高,但在原猴或其他哺乳动物中则没有升高。

Pascarella, Giovanni; Conner, Kayla N; Goff, Noah J; Carninci, Piero; Olive, Andrew J; Meek, Katheryn

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining.

两种不同的长程突触复合物促进DNA断裂通过非同源末端连接修复之前末端加工的不同方面

Buehl Christopher J, Goff Noah J, Hardwick Steven W, Gellert Martin, Blundell Tom L, Yang Wei, Chaplin Amanda K, Meek Katheryn

Unravelling the complexities of DNA-PK activation by structure-based mutagenesis

通过基于结构的诱变揭示DNA-PK激活的复杂性

Buehl, Christopher J; Goff, Noah J; Mikhova, Mariia; Hardwick, Steven W; Blundell, Thomas L; Modesti, Mauro; Schmidt, Jens C; Chaplin, Amanda; Meek, Katheryn

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

揭示DNA-PKcs的古老系统发育、独特序列基序及其对人类疾病的启示

Lees-Miller, James P; Cobban, Alexander; Katsonis, Panagiotis; Bacolla, Albino; Tsutakawa, Susan E; Hammel, Michal; Meek, Katheryn; Anderson, Dave W; Lichtarge, Olivier; Tainer, John A; Lees-Miller, Susan P

Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining

在DNA-PKcs缺陷细胞中恢复ATM表达可抑制信号末端连接

Neal, Jessica A; Xu, Yao; Abe, Masumi; Hendrickson, Eric; Meek, Katheryn