日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

UVI5008: the first reversible, non-covalent Bruton's tyrosine kinase epi-inhibitor for B-cell malignancies

UVI5008:首个用于治疗B细胞恶性肿瘤的可逆性非共价布鲁顿酪氨酸激酶表观抑制剂

Dell'Aversana, Carmela; Sgueglia, G; Massaro, C; Perricone, U; Sarno, F; Megchelenbrink, W L; Conte, M; Carafa, V; Campanella, A; Frenquelli, M; Bordini, J; Ghia, P; Petrizzi, V B; Alvarez, R; Nappi, D; Chiurazzi, F; Tambaro, F P; Wierda, W G; de Lera, A R; Altucci, Lucia

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans

全身性炎症会损害人类的髓系造血和I型干扰素反应。

Farid Keramati # ,Guus P Leijte #,Niklas Bruse #,Inge Grondman,Ehsan Habibi ,Cristian Ruiz-Moreno,Wout Megchelenbrink,Annemieke M Peters van Ton,Hidde Heesakkers,Manita E Bremmers,Erinke van Grinsven,Kiki Tesselaar,Selma van Staveren,Walter J van der Velden,Frank W Preijers,Brigit Te Pas,Raoul van de Loop,Jelle Gerretsen,Mihai G Netea,Hendrik G Stunnenberg,Peter Pickkers,Matthijs Kox

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans

全身性炎症会损害人类的髓系造血和I型干扰素反应。

Keramati, Farid; Leijte, Guus P; Bruse, Niklas; Grondman, Inge; Habibi, Ehsan; Ruiz-Moreno, Cristian; Megchelenbrink, Wout; Peters van Ton, Annemieke M; Heesakkers, Hidde; Bremmers, Manita E; van Grinsven, Erinke; Tesselaar, Kiki; van Staveren, Selma; van der Velden, Walter J; Preijers, Frank W; Te Pas, Brigit; van de Loop, Raoul; Gerretsen, Jelle; Netea, Mihai G; Stunnenberg, Hendrik G; Pickkers, Peter; Kox, Matthijs

METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.

METTL16 介导的 MXD4 抑制通过激活 MYC-MAX 轴促进白血病。

Bove Guglielmo, Babaei Mehrad, Bueno-Costa Alberto, Amin Sajid, Simonelli Nicla, Benedetti Rosaria, Dell'Aversana Carmela, Conte Mariarosaria, Montella Liliana, Summa Vincenzo, Brindisi Margherita, Del Sorbo Maria Rosaria, Crepaldi Marco, Favale Gregorio, Profitos-Peleja Nuria, Carafa Vincenzo, Roué Gaël, Ciardiello Fortunato, Capuano Annalisa, Stunnenberg Hendrik G, Megchelenbrink Wouter L, Nebbioso Angela, Esteller Manel, Altucci Lucia, Del Gaudio Nunzio

Single-cell multi-omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC-unique features

单细胞多组学分析可用于表征结直肠肿瘤、邻近健康组织和匹配的(肿瘤)类器官,从而识别结直肠癌特有的特征。

Yu, Zhijun; Derksen, Merel; Te Pas, Brigit M; Ladstätter, Sabrina; Overmeer, Rene; Brazda, Peter; van de Wetering, Marc; Pourfarzad, Farzin; Vries, Robert G J; Megchelenbrink, Wout; Bock, Christoph; Altucci, Lucia; Stunnenberg, Hendrik G

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids.

肝母细胞瘤肿瘤和类器官中 WNT 信号传导和药物敏感性特征的差异

Kluiver Thomas A, Lu Yuyan, Schubert Stephanie A, Kraaier Lianne J, Ringnalda Femke, Lijnzaad Philip, DeMartino Jeff, Megchelenbrink Wouter L, Amo-Addae Vicky, Eising Selma, de Faria Flavia W, Münter Daniel, van de Wetering Marc, Kerl Kornelius, Duiker Evelien, van den Heuvel Marius C, de Meijer Vincent E, de Kleine Ruben H, Molenaar Jan J, Margaritis Thanasis, Stunnenberg Hendrik G, de Krijger Ronald R, Zsiros József, Clevers Hans, Peng Weng Chuan

Inverse FASN and LDHA correlation drives metabolic resistance in breast cancer

FASN 和 LDHA 的逆相关性驱动乳腺癌的代谢耐药性

Chiara Papulino #, Ugo Chianese #, Ahmad Ali, Gregorio Favale, Concetta Tuccillo, Fortunato Ciardiello, Annabella Di Mauro, Chiara Mignogna, Gerardo Ferrara, Alfredo Budillon, Wouter Leonard Megchelenbrink, Nunzio Del Gaudio, Mariarosaria Conte, Fabrizio Merciai, Pietro Campiglia, Lucia Altucci, Vin

Cancer Therapy Resistance: Choosing Kinase Inhibitors

癌症治疗耐药性:激酶抑制剂的选择

Dell'Aversana, Carmela; Sarno, Federica; Benedetti, Rosaria; Megchelenbrink, Wouter Leonard; Cappetta, Donato

Deregulation of New Cell Death Mechanisms in Leukemia

白血病中新的细胞死亡机制失调

Favale, Gregorio; Donnarumma, Federica; Capone, Vincenza; Della Torre, Laura; Beato, Antonio; Carannante, Daniela; Verrilli, Giulia; Nawaz, Asmat; Grimaldi, Francesco; De Simone, Maria Carla; Del Gaudio, Nunzio; Megchelenbrink, Wouter Leonard; Caraglia, Michele; Benedetti, Rosaria; Altucci, Lucia; Carafa, Vincenzo

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

纵向单细胞转录组学揭示急性髓系白血病复发的不同模式

Zhai, Yanan; Singh, Prashant; Dolnik, Anna; Brazda, Peter; Atlasy, Nader; Del Gaudio, Nunzio; Döhner, Konstanze; Döhner, Hartmut; Minucci, Saverio; Martens, Joost; Altucci, Lucia; Megchelenbrink, Wout; Bullinger, Lars; Stunnenberg, Hendrik G