日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

T-cell Priming by High-Avidity Neoantigens in Lymph Nodes Augments Adoptive Immunotherapy

淋巴结中高亲和力新抗原启动T细胞可增强过继性免疫疗法

Wittling, Megen C; Rivera-Reyes, Amalia M; Wyatt, Megan M; Cole, Anna C; Smith, Aubrey S; Rangel Rivera, Guillermo O; Carmouche, James H 3rd; Diatikar, Kailey G; Ruffin, Ayana T; Ware, Michael B; Bennett, Frances J; Dwyer, Connor J; Pihl, Riley M F; Kumaresan, Soundharya; Lesinski, Gregory B; Paulos, Chrystal M; Knochelmann, Hannah M

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

过继转移的Th17细胞与宿主B细胞协同作用,可实现持久的肿瘤免疫。

Anna C Cole ,Hannah M Knochelmann ,Megan M Wyatt ,Megen C Wittling ,Natalie K Horvat ,Aubrey S Smith ,Guillermo O Rangel Rivera ,Amalia M Rivera Reyes ,Bhavana Pavuluri ,Soundharya Kumaresan ,Pawel Muranski ,Ayana T Ruffin ,Jeremy M Boss ,Gregory B Lesinski ,Chrystal M Paulos

Tumor site influences efficacy of MEKi and immunotherapy combinations in a preclinical model of cholangiocarcinoma

肿瘤部位影响胆管癌临床前模型中MEK抑制剂和免疫疗法联合治疗的疗效

Hammons, Jacklyn N; Warren, Emilie K; Wittling, Megen C; Bennett, Frances J; Rangel-Rivera, Guillermo O; Mack, Alexis F; Phillips, Maggie J; Robinson, Brian S; Krasinskas, Alyssa M; Horvat, Natalie K; Ruffin, Ayana T; Liu, Yuan; Cao, Yichun; Azad, Nilofer N S; Yarchoan, Mark M; Heumann, Thatcher; Keler, Tibor; Maithel, Shishir K; Paulos, Chrystal M; Lesinski, Gregory B

Constructing the cure: engineering the next wave of antibody and cellular immune therapies

构建治愈方案:设计下一代抗体和细胞免疫疗法

Bailey, Stefanie R; Bartee, Eric; Daniels, Kyle G; Heery, Christopher R; Kaumaya, Pravin; Lesinski, Gregory B; Lowinger, Timothy B; Nelson, Michelle H; Rubinstein, Mark P; Wittling, Megen C; Paulos, Chrystal M; Posey, Avery D Jr

CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors

CD4 T 细胞耗竭可增加内源性和 CAR T 细胞的记忆分化,并增强 Super2 和 IL-33 装甲 CAR T 细胞对实体肿瘤的疗效

Asmaa O Mohamed #, David Tyler Boone #, Shannon L Ferry, Melanie C Peck, Alicia M Santos, Haille E Soderholm, Megen C Wittling, Chrystal Paulos, Mary Jo Turk, Yina H Huang

Development of a murine tumor-infiltrating lymphocyte therapy model for cholangiocarcinoma

建立小鼠肿瘤浸润淋巴细胞治疗胆管癌模型

Megen C Wittling ,Frances J Bennett ,Emilie A K Warren ,Kailey M Oppat ,Megan M Wyatt ,Jacklyn N Hammons ,Yuan Liu ,Shishir K Maithel ,Chrystal M Paulos ,Gregory B Lesinski

Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells

不同的宿主预处理方案对过继转移的Th17细胞的抗肿瘤效力有不同的影响。

Wittling, Megen C; Knochelmann, Hannah M; Wyatt, Megan M; Rangel Rivera, Guillermo O; Cole, Anna C; Lesinski, Gregory B; Paulos, Chrystal M

IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells

IL15 和 IL21:在抗肿瘤 T 细胞上通过膜连接在一起效果更佳

Ruffin, Ayana T; Wittling, Megen C; Cole, Anna C; Paulos, Chrystal M

Strategies for Improving CAR T Cell Persistence in Solid Tumors

提高CAR-T细胞在实体瘤中持久性的策略

Wittling, Megen C; Cole, Anna C; Brammer, Brianna; Diatikar, Kailey G; Schmitt, Nicole C; Paulos, Chrystal M