日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage

PINK1 依赖的线粒体自噬可抑制线粒体损伤引起的泛素磷酸化升高

Olivia A Lambourne, Shane Bell, Léa P Wilhelm, Erika B Yarbrough, Gabriel G Holly, Oliver M Russell, Arwa M Alghamdi, Azeza M Fdel, Carmine Varricchio, Emma L Lane, Ian G Ganley, Arwyn T Jones, Matthew S Goldberg, Youcef Mehellou

Generation of Stable Isopentenyl Monophosphate Aryloxy Triester Phosphoramidates as Activators of Vγ9Vδ2 T Cells

生成稳定的异戊烯基单磷酸芳氧基三酯磷酰胺作为Vγ9Vδ2 T细胞激活剂

Xu, Qin; Taher, Taher E; Ashby, Elizabeth; Sharif, Maria; Willcox, Benjamin E; Mehellou, Youcef

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner

Cul4-DDB1-WDR3/WDR6 复合物以磷酸化依赖的方式结合 SPAK 和 OSR1 激酶

Binar A Dhiani, Youcef Mehellou

The ProTide Prodrug Technology: From the Concept to the Clinic

ProTide前药技术:从概念到临床

Mehellou, Youcef; Rattan, Hardeep S; Balzarini, Jan

Niclosamide, a Drug with Many (Re)purposes

尼克洛沙胺,一种用途广泛的药物

Kadri, Hachemi; Lambourne, Olivia A; Mehellou, Youcef

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

驱虫药尼克洛沙胺及其类似物可激活帕金森病相关蛋白激酶PINK1。

Barini, Erica; Miccoli, Ageo; Tinarelli, Federico; Mulholland, Katie; Kadri, Hachemi; Khanim, Farhat; Stojanovski, Laste; Read, Kevin D; Burness, Kerry; Blow, Julian J; Mehellou, Youcef; Muqit, Miratul M K

Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs

磷酸酪氨酸前药:ISS-610 芳氧基三酯磷酸酰胺前药的设计、合成及抗 STAT3 活性

Ageo Miccoli, Binar A Dhiani, Youcef Mehellou

Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

激动素核苷及其前肽激活帕金森病相关的PTEN诱导的假定激酶1 (PINK1),且该过程不依赖于线粒体去极化

Osgerby, Laura; Lai, Yu-Chiang; Thornton, Peter J; Amalfitano, Joseph; Le Duff, Cécile S; Jabeen, Iqra; Kadri, Hachemi; Miccoli, Ageo; Tucker, James H R; Muqit, Miratul M K; Mehellou, Youcef

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain

BTN3A1 通过其 B30.2 结构域中的构象传感器区分 γδ T 细胞磷酸抗原和非抗原小分子

Mahboob Salim, Timothy J Knowles, Alfie T Baker, Martin S Davey, Mark Jeeves, Pooja Sridhar, John Wilkie, Carrie R Willcox, Hachemi Kadri, Taher E Taher, Pierre Vantourout, Adrian Hayday, Youcef Mehellou, Fiyaz Mohammed, Benjamin E Willcox

The ProTides Boom

ProTides 的繁荣

Mehellou, Youcef