日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-resolution visualisation of antisense oligonucleotide release from polymers in cells

反义寡核苷酸从细胞中的聚合物中释放的高分辨率可视化

Jessica J King, Kai Chen, Cameron W Evans, Marck Norret, Ruba Almasri, Nathan J Pavlos, Henry Yl Hui, Qiongxiang Lin, Uditi Bhatt, Stephen G Young, Nicole M Smith, Mehran Nikan, Clive A Prestidge, Haibo Jiang, K Swaminathan Iyer

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory

抑制 Cpeb3 核酶可提高 CPEB3 蛋白表达及其靶 mRNA 的多聚腺苷酸化,并增强物体位置记忆

Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz F M Passalacqua, Timothy Bredy, Marcelo A Wood, Andrej Luptak

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

抑制 CPEB3 核酶可提高 CPEB3 蛋白表达及其靶 mRNA 的多聚腺苷酸化,并增强物体位置记忆

Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, Liqi Tong, Luiz F M Passalacqua, Timothy W Bredy, Marcelo A Wood, Andrej Lupták

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

部分和完全化学修饰的 siRNA 在体内结合介导递送中的比较

Matthew R Hassler, Anton A Turanov, Julia F Alterman, Reka A Haraszti, Andrew H Coles, Maire F Osborn, Dimas Echeverria, Mehran Nikan, William E Salomon, Loïc Roux, Bruno M D C Godinho, Sarah M Davis, David V Morrissey, Phillip D Zamore, S Ananth Karumanchi, Melissa J Moore, Neil Aronin, Anastasia K

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

疏水修饰 siRNA 的经血管递送:血脑屏障破坏后大鼠脑内基因沉默

Bruno M D C Godinho, Nils Henninger, James Bouley, Julia F Alterman, Reka A Haraszti, James W Gilbert, Ellen Sapp, Andrew H Coles, Annabelle Biscans, Mehran Nikan, Dimas Echeverria, Marian DiFiglia, Neil Aronin, Anastasia Khvorova

Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

脂质结合 siRNA 的疏水性可预测小细胞外囊泡的有效装载

Annabelle Biscans, Reka A Haraszti, Dimas Echeverria, Rachael Miller, Marie-Cecile Didiot, Mehran Nikan, Loic Roux, Neil Aronin, Anastasia Khvorova

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay

共轭治疗性寡核苷酸的药代动力学分析:一种基于连续血液微量采样结合肽核酸杂交试验的高通量方法

Bruno M D C Godinho, James W Gilbert, Reka A Haraszti, Andrew H Coles, Annabelle Biscans, Loic Roux, Mehran Nikan, Dimas Echeverria, Matthew Hassler, Anastasia Khvorova

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

胍基苯 (Wytensin™) 选择性增强疏水修饰 siRNA 的吸收和功效

Maire F Osborn, Julia F Alterman, Mehran Nikan, Hong Cao, Marie C Didiot, Matthew R Hassler, Andrew H Coles, Anastasia Khvorova

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

小分子诱导的DNA损伤可识别人类基因中的替代DNA结构

Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan, Sébastien Britton, Tobias Oelschlaegel, Blerta Xhemalce, Shankar Balasubramanian, Stephen P Jackson