日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

表达细胞表面不依赖裂解的 HIV Env 三聚体的 mRNA 脂质纳米粒子可引发自体 2 级中和抗体

Javier Guenaga #, Mehrdad Alirezaei #, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K Diedrich, John R Yates 3rd, James C Paulson, Andrew B Ward, Drew Weissman, Richard T Wyatt

Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response

分子佐剂 C3d 与不依赖切割的天然 HIV-1 Env 三聚体的融合可改善所引发的抗体反应

Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D Doyle, Christopher A Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B Ward, Richard T Wyatt

A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis

食物反应开关调节 TFEB 和自噬,并决定对柯萨奇病毒感染和胰腺炎的易感性

Mehrdad Alirezaei, Claudia T Flynn, Selma D Garcia, Taishi Kimura, J Lindsay Whitton

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection

双相和心肌细胞特异性 IFIT 活性保护心肌细胞免受肠道病毒感染

Taishi Kimura, Claudia T Flynn, Mehrdad Alirezaei, Ganes C Sen, J Lindsay Whitton

Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo

柯萨奇病毒在体内既可以依赖自噬,也可以不依赖自噬,从而利用LC3。

Mehrdad Alirezaei ,Claudia T Flynn, Malcolm R Wood, Stephanie Harkins, J Lindsay Whitton

In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease

体内消除心肌细胞 I 型干扰素受体可延迟柯萨奇病毒清除并加速心肌疾病

Nadine Althof, Stephanie Harkins, Christopher C Kemball, Claudia T Flynn, Mehrdad Alirezaei, J Lindsay Whitton

An integrated systems analysis implicates EGR1 downregulation in simian immunodeficiency virus encephalitis-induced neural dysfunction

综合系统分析表明,EGR1下调与猴免疫缺陷病毒脑炎引起的神经功能障碍有关。

Merril Gersten,Mehrdad Alirezaei, Maria Cecilia Garibaldi Marcondes, Claudia Flynn, Timothy Ravasi, Trey Ideker, Howard S Fox

Disruption of neuronal autophagy by infected microglia results in neurodegeneration

受感染的小胶质细胞破坏神经元自噬,导致神经退行性病变

Mehrdad Alirezaei, William B Kiosses, Claudia T Flynn, Nathan R Brady, Howard S Fox