The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS.
冷冻电镜揭示的 CXCR4 激动剂模拟机制能够在 ALS 小鼠模型中实现广泛的干细胞神经保护
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doi:10.1101/2025.07.08.663251
Sang Xiaohong, Jiao Haizhan, Meng Qian, Fang Xiong, Sundaram Kartik S, Zhou Jiao, Xu Yan, Alvarado Asuka I W, Nuryyev Ruslan L, Ourenik Jitka, Ourednik Vaclav, Huang Iris S, Liu Xiang, Mei Yuheng, Qian Tingli, Ciechanover Aaron, Pizzo Donald P, Lane Michael A, Zholudeva Lyandysha V, An Jing, Snyder Evan Y, Hu Hongli, Huang Ziwei
