日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.

TNG260 是一种小分子 CoREST 抑制剂,可使 STK11 突变肿瘤对 PD-1 抗肿瘤免疫疗法敏感。

Ahronian Leanne G, Sahu Soumyadip, Zhang Minjie, Patel Ayushi S, Geng Ke, Bhattacharya Reshmee, Falchook Gerald S, Goldman Jonathan W, Spira Alexander I, Punekar Salman R, Spigel David R, Wang Judy S, Skoulidis Ferdinandos, Stephens Janaye, Meynardie Mary, Powell Jaylen M, Lopez Alfonso, Ranieri Michela, Ploszaj Magdalena A, Tan Yi Jer, Lee Yeuan Ting, Yu Yi, Deng Jiehui, Chen Ting, McCarren Patrick, Tsai Alice, Hussain Suleman S, Doyon Brian, Amemiya Kenjie, Ermolieff Jacques, Shahagadkar Preksha, Das Nikitha M, Flynn Lauren R, Shields Julie A, Danielczyk Laney, McMillan Brian J, Mignault Andre, Meier Samuel R, Wu Hsin-Jung, Guerin David J, Whittington Douglas A, Min Chengyin, Sienczylo Iga, Maxwell John P, DiBenedetto Heather J, Watanabe Hideo, Haines Brian B, Huang Alan, Crystal Adam, Andersen Jannik N, Wu Xinyuan, Wong Kwok-Kin

Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.

TNG348 的特性:一种选择性变构 USP1 抑制剂,可与 PARP 抑制剂在同源重组缺陷肿瘤中发挥协同作用

Simoneau Antoine, Pratt Charlotte B, Wu Hsin-Jung, Rajeswaran Shreya S, Comer Charlotte Grace, Sudsakorn Sirimas, Zhang Wenhai, Liu Shangtao, Meier Samuel R, Choi Ashley H, Khendu Tenzing, Stowe Hannah, Shen Binzhang, Whittington Douglas A, Chen Yingnan, Yu Yi, Mallender William D, Feng Tianshu, Andersen Jannik N, Maxwell John P, Throner Scott

TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers

TNG908 是一种可穿透血脑屏障的 MTA 协同 PRMT5 抑制剂,专为治疗 MTAP 缺失型癌症而开发。

Briggs, Kimberly J; Cottrell, Kevin M; Tonini, Matthew R; Tsai, Alice; Zhang, Minjie; Whittington, Douglas A; Zhang, Wenhai; Lombardo, Steven A; Yoda, Satoshi; Wilker, Erik W; Meier, Samuel R; Yu, Yi; Teng, Teng; Huang, Alan; Maxwell, John P

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor

全面检验STK11肿瘤抑制基因错义变异的功能

Zimmerman, Daniel; Cote, Atina; van Loggerenberg, Warren; Gebbia, Marinella; Kishore, Nishka; Weile, Jochen; Li, Roujia; Reno, Chloe; Marsh, Ashley Pl; Hernandez, Felicia; Shahagadkar, Preksha; Grove, Lauren; Meier, Samuel R; Wu, Hsin-Jung; Fenoglio, Silvia; Ahronian, Leanne; Teng, Teng; Waters, Andrew J; Seward, David; Taipale, Mikko; Aronson, Melyssa; Richardson, Marcy E; Adams, David J; Roth, Frederick P

VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma

VRK1是VRK2缺陷型胶质母细胞瘤的合成致死靶点

Shields, Julie A; Meier, Samuel R; Bandi, Madhavi; Mulkearns-Hubert, Erin E; Hajdari, Nicole; Ferdinez, Maria Dam; Engel, Justin L; Silver, Daniel J; Shen, Binzhang; Zhang, Wenhai; Hubert, Christopher G; Mitchell, Kelly; Shakya, Sajina; Zhao, Shan-Chuan; Bejnood, Alborz; Zhang, Minjie; Tjin Tham Sjin, Robert; Wilker, Erik; Lathia, Justin D; Andersen, Jannik N; Chen, Yingnan; Li, Fang; Weber, Barbara; Huang, Alan; Emmanuel, Natasha

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

组蛋白去甲基化酶KDM6A直接感知氧气,从而调控染色质和细胞命运。

Chakraborty, Abhishek A; Laukka, Tuomas; Myllykoski, Matti; Ringel, Alison E; Booker, Matthew A; Tolstorukov, Michael Y; Meng, Yuzhong Jeff; Meier, Samuel R; Jennings, Rebecca B; Creech, Amanda L; Herbert, Zachary T; McBrayer, Samuel K; Olenchock, Benjamin A; Jaffe, Jacob D; Haigis, Marcia C; Beroukhim, Rameen; Signoretti, Sabina; Koivunen, Peppi; Kaelin, William G Jr