mtDNA leakage promotes neuron-glia crosstalk to induce epilepsy by cGAS-STING-driven neuroinflammation and serine metabolic reprogramming
线粒体DNA泄漏促进神经元-胶质细胞串扰,通过cGAS-STING驱动的神经炎症和丝氨酸代谢重编程诱发癫痫
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2522313123
Jiang, Jie; Zuo, Meiling; Zhao, Kehan; Ling, Zhihao; Wu, Zhida; Xue, Dongfang; Mo, Shouyong; Liu, Yuanhui; Chen, Yongjun; Wang, Jie; Lu, Bin; Li, Chuanzhou; Duan, Yaqi; He, He; Song, Zhiyin
胶质细胞
炎症
炎症/感染
STING
癫痫
cGAS-STING
神经科学
代谢
代谢重编程
线粒体
细胞生物学
神经炎症