日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a First-in-Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

发现一种具有免疫治疗活性的首创共价变构SHP1抑制剂

Qu, Zihan; Meke, Frederick Nguele; Zhang, Zheng; Krabill, Aaron D; Muli, Christine S; Jassim, Brenson A; Dong, Jiajun; Nguyen, Quyen D; Bai, Yunpeng; Li, Jinyue; Miao, Yiming; Asadi, Bardia; Johnson, Levi M; Miao, Jinmin; Trader, Darci J; Tao, W Andy; Zhang, Zhong-Yin

Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase

发现和评价活性位点导向的、高效、选择性磺基苯乙酸酰胺类拉福林磷酸酶抑制剂

Lin, Jianping; He, Rongjun; Qu, Zihan; Dong, Jiajun; Krabill, Aaron D; Wu, Li; Bai, Yunpeng; Conroy, Lindsey R; Bruntz, Ronald C; Miao, Yiming; Jassim, Brenson A; Babalola, Benjamin; Nguele Meke, Frederick Georges Bernard; Sun, Ramon; Gentry, Matthew S; Zhang, Zhong-Yin

The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor.

PRL2 磷酸酶通过激活 JAK2/STAT3 通路上调 miR-21,从而下调 PTEN 肿瘤抑制因子

Li Qinglin, Bai Yunpeng, Cavender Sarah M, Miao Yiming, Nguele Meke Frederick, Lasse-Opsahl Emily L, Zhu Peipei, Doody Gina M, Tao W Andy, Zhang Zhong-Yin

Molecular detection of human-derived Jingmenvirus in multiple mosquito species from Yaoundé, Cameroon

在喀麦隆雅温得多种蚊子体内检测到人源京门病毒

Lisandru Capai,Giovanni Begliomini,Basile Kamgang,Souand Mohamed Ali,Sarah Temmam,Thomas Bigot,Gisèle Liliane Machuetum,Christophe R Keumeni,Francine S Yousseu,Christian Nsangou Yogne,Gael Dieudonné Essima,Landry Mounchili,Christian Meke,Vincent Kome,Rodrigue Poueme,Ahmadou Alkaissou,Richard Njouom,Paul Alain Tagnouokam-Ngoupo,Nolwenn M Dheilly

A new potential mosquito-borne virus: detection of Human-derived Jingmenvirus in several-species of mosquitoes from Yaoundé, Cameroon

一种新的潜在蚊媒病毒:在喀麦隆雅温得的几种蚊子体内检测到人源性京门病毒

Capai, Lisandru; Begliomini, Giovanni; Kamgang, Basile; Ali, Souand Mohamed; Temmam, Sarah; Bigot, Thomas; Machuetum, Gisèle Liliane; Keumeni, Christophe R; Sado, Francine Yousseu; Nsangou, Christian Yogne; Essima, Gael Dieudonné; Mounchili, Landry; Meke, Christian; Kome, Vincent; Poueme, Rodrigue; Alkaissou, Ahmadou; Njouom, Richard; Tagnouokam-Ngoupo, Paul Alain; Dheilly, Nolwenn M

Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers

SHP2 变构抑制剂的脱靶自噬抑制有助于其在 RAS 驱动的癌症中发挥抗肿瘤活性

Yiming Miao, Yunpeng Bai, Jinmin Miao, Allison A Murray, Jianping Lin, Jiajun Dong, Zihan Qu, Ruo-Yu Zhang, Quyen D Nguyen, Shaomeng Wang, Jingmei Yu, Frederick Nguele Meke, Zhong-Yin Zhang

PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation

PRL2磷酸酶通过调节CBL磷酸化促进白血病细胞中的致癌KIT信号传导

Hongxia Chen #, Yunpeng Bai #, Michihiro Kobayashi, Shiyu Xiao, Sergio Barajas, Wenjie Cai, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Chonghua Yao, Yuxia Yang, Katherine Strube, Odelia Satchivi, Jianmin Sun, Lars Rönnstrand, James M Croop, H Scott Boswell, Yuzhi Jia, Huiping Liu, Loretta S Li, 

Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models

抑制PRL2可上调PTEN并减弱Tp53缺陷型肉瘤和淋巴瘤小鼠模型中的肿瘤生长

Frederick Nguele Meke # ,Yunpeng Bai # ,Diego Ruiz-Avila ,Colin Carlock ,Jinan Ayub ,Jinmin Miao ,Yanyang Hu ,Qinglin Li ,Zhong-Yin Zhang

Correlative Imaging for Comprehensive Molecular Mapping of Individual Cell Types in Biological Tissues

用于生物组织中单个细胞类型全面分子图谱绘制的相关成像

Yang, Manxi; Iqfath, Mushfeqa; Meke, Frederick Nguele; Qu, Zihan; Hernly, Emerson L; Su, Pei; Zhang, Zhong-Yin; Laskin, Julia

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

PRL2磷酸酶通过酪氨酸371位点的去磷酸化增强致癌FLT3信号传导。

Chen, Hongxia; Bai, Yunpeng; Kobayashi, Michihiro; Xiao, Shiyu; Cai, Wenjie; Barajas, Sergio; Chen, Sisi; Miao, Jinmin; Meke, Frederick Nguele; Vemula, Sasidhar; Ropa, James P; Croop, James M; Boswell, H Scott; Wan, Jun; Jia, Yuzhi; Liu, Huiping; Li, Loretta S; Altman, Jessica K; Eklund, Elizabeth A; Ji, Peng; Tong, Wei; Band, Hamid; Huang, Danny T; Platanias, Leonidas C; Zhang, Zhong-Yin; Liu, Yan