日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis of a Hydroxy-15-Azasterol

羟基-15-氮杂甾醇的合成

Jones, Caleb A H; Melancon, Bruce J; Lindsley, Craig W

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现:一种进入临床试验的 M(1) 正向变构调节剂候选药物

Poslunsey, Michael S; Wood, Michael R; Han, Changho; Stauffer, Shaun R; Panarese, Joseph D; Melancon, Bruce J; Engers, Julie L; Dickerson, Jonathan W; Peng, Weimin; Noetzel, Meredith J; Cho, Hyekyung P; Rodriguez, Alice L; Hopkins, Corey R; Morrison, Ryan; Crouch, Rachel D; Bridges, Thomas M; Blobaum, Anna L; Boutaud, Olivier; Daniels, J Scott; Kates, Michael J; Castelhano, Arlindo; Rook, Jerri M; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

Further Optimization of the mGlu(1) PAM VU6024578/BI02982816: Discovery and Characterization of VU6033685

mGlu(1) PAM VU6024578/BI02982816 的进一步优化:VU6033685 的发现和表征

Reed, Carson W; Kalbfleisch, Jacob F; Turkett, Jeremy A; Trombley, Trevor A; Spearing, Paul K; Haymer, Daniel H; Quitalig, Marc; Dickerson, Jonathan W; Foster, Daniel J; Blobaum, Annie L; Boutaud, Olivier; Cho, Hyekyung P; Niswender, Colleen M; Rook, Jerri M; Priepke, Henning; Sommer, Heiko; Scheuerer, Stefan; Ursu, Daniel; Conn, P Jeffrey; Melancon, Bruce J; Lindsley, Craig W

Discovery of VU6024578/BI02982816: An mGlu(1) Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models

VU6024578/BI02982816 的发现:一种 mGlu(1) 正向变构调节剂,在临床前抗精神病和认知模型中具有疗效

Reed, Carson W; Kalbfleisch, Jacob F; Turkett, Jeremy A; Trombley, Trevor A; Nastase, Anthony F; Spearing, Paul K; Haymer, Daniel H; Sarwar, Mohammad Moshin; Quitalig, Marc; Dickerson, Jonathan W; Blobaum, Annie L; Boutaud, Olivier; Voehringer, Patrizia; Schuelert, Niklas; Cho, Hyekyung P; Niswender, Colleen M; Rook, Jerri M; Priepke, Henning; Ursu, Daniel; Conn, P Jeffrey; Melancon, Bruce J; Lindsley, Craig W

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

基于多基因风险评分的乳腺癌筛查临床建议:Can.Heal 项目

Bubser, Michael; Bridges, Thomas M; Dencker, Ditte; Gould, Robert W; Grannan, Michael; Noetzel, Meredith J; Lamsal, Atin; Niswender, Colleen M; Daniels, J Scott; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Byers, Frank W; Wess, Jürgen; Duggan, Mark E; Dunlop, John; Wood, Michael W; Brandon, Nicholas J; Wood, Michael R; Lindsley, Craig W; Conn, P Jeffrey; Jones, Carrie K; Taha, A; Matt McCrary, J; van Rooij, J; Lahousse, L; Paoletti, F; Pascucci, E; Vaht, M; Pastorino, R; Pezzullo, A M; Boccia, S

Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M(1) Positive Allosteric Modulators

发现三环三唑并吡啶内酰胺和咪唑并吡啶内酰胺作为 M(1) 正变构调节剂

Engers, Julie L; Bender, Aaron M; Kalbfleisch, Jacob J; Cho, Hyekyung P; Lingenfelter, Kaelyn S; Luscombe, Vincent B; Han, Changho; Melancon, Bruce J; Blobaum, Anna L; Dickerson, Jonathan W; Rook, Jerri M; Niswender, Colleen M; Emmitte, Kyle A; Conn, P Jeffrey; Lindsley, Craig W

Novel M(4) positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands

通过质疑β-氨基羧酰胺配体中假定的分子内氢键基序的作用和影响,开发出新型M(4)正变构调节剂

Poslusney, Michael S; Salovich, James M; Wood, Michael R; Melancon, Bruce J; Bollinger, Katrina A; Luscombe, Vincent B; Rodriguez, Alice L; Engers, Darren W; Bridges, Thomas M; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M(4) PAMs

受醛氧化酶 (AO) 代谢启发的 SAR 研究:新型中枢神经系统穿透性三环 M(4) PAM 的发现

Chopko, Trevor C; Han, Changho; Gregro, Alison R; Engers, Darren W; Felts, Andrew S; Poslusney, Mike S; Bollinger, Katrina A; Morrison, Ryan D; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B; Cho, Hyekyung P; Schnetz-Boutaud, Nathalie C; Rodriguez, Alice L; Chang, Sichen; Daniels, J Scott; Stec, Donald F; Niswender, Colleen M; Jones, Carrie K; Wood, Michael R; Wood, Michael W; Duggan, Mark E; Brandon, Nicholas J; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W; Melancon, Bruce J

Corrigendum to "Challenges in the development of an M(4) PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]

对“M(4) PAM 临床前候选药物开发中的挑战:一系列氮杂环丁烷衍生的叔酰胺的发现、构效关系和生物学表征”的更正 [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184]

Tarr, James C; Wood, Michael R; Noetzel, Meredith J; Melancon, Bruce J; Lamsal, Atin; Luscombe, Vincent B; Rodriguez, Alice L; Byers, Frank W; Chang, Sichen; Cho, Hyekyung P; Engers, Darren W; Jones, Carrie K; Niswender, Colleen M; Wood, Michael W; Brandon, Nicholas J; Duggan, Mark E; Jeffrey Conn, P; Bridges, Thomas M; Lindsley, Craig W

Challenges in the development of an M(4) PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

M(4) PAM 体内工具化合物开发面临的挑战:VU0467154 的发现及其近缘类似物出乎意料的 DMPK 特征

Wood, Michael R; Noetzel, Meredith J; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B; Weiner, Rebecca L; Cho, Hyekyung P; Bubser, Michael; Jones, Carrie K; Niswender, Colleen M; Wood, Michael W; Engers, Darren W; Brandon, Nicholas J; Duggan, Mark E; Conn, P Jeffrey; Bridges, Thomas M; Lindsley, Craig W