日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy

肿瘤和基质细胞中的坏死性凋亡决定了对基于免疫原性细胞死亡的免疫疗法的反应性。

Fernando, Winnie; Clucas, Jarama; Rizzo, Alberto; Singer, Ramsay; Goode, Emily; Tiu, Crescens; Layzell, Scott; Konecnik, Joshua; Wilson, Rebecca; Wicky John, Sidonie; Jouny, Samuel; Guppy, Naomi; Boulat, Victoire; Mannion, Jonathan; Goicoechea, Maria; Tan, Shaun; Lawson, Sam; Starling, Chris; Elshtein, Gabrielle; Ravindran, Nivedita; Montgomery, Anna B; Andres-Ejarque, Rosa; Allen, Mark; Lumbard, Steven; Wallberg, Fredrik; Betteridge, Kai; Scrimgeour, Ross; Robertson, David; Ward, George; Sims, Martin; Smyth, Tomoko; Samson, Andre L; Murphy, James M; Kolarevic Ivankovic, Daniela; Arwert, Esther N; Calado, Dinis P; Grigoriadis, Anita; Smalley, Matthew J; Melcher, Alan; Haider, Syed; Lawrence, Toby; Roxanis, Ioannis; Tutt, Andrew N J; Tenev, Tencho; Meier, Pascal

Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling

溶瘤免疫疗法使用RP1(vusolimogene oderparepvec)对免疫细胞的影响通过STING介导的干扰素信号传导来调节对PD-1抗体的反应性

Roulstone, Victoria; Kyula, Joan; Appleton, Elizabeth; Bommareddy, Praveen K; Patrikeev, Anton; Jones, Sylwia; Kuncheria, Linta; Chan Wah Hak, Charleen Ml; Foo, Shane; Baldock, Holly; Wongariyapak, Amarin; Leslie, Isla; Pickering, Robert; Zierhut, Christian; Smith, Henry G; Mohan, Nitya; Murano, Carmen; Hubbard, Lisa C; Dean, Isaac; Patin, Emmanuel Christian; Gkantalis, Jim; Mansfield, David; Pedersen, Malin; McLaughlin, Martin; Goicoechea, Maria; Layzell, Scott; Mannion, Jonathan; Fernando, Winnie; Meier, Pascal; Vile, Richard; Melcher, Alan; Coffin, Robert S; Harrington, Kevin J

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

单次与重复静脉注射溶瘤呼肠孤病毒:对肝细胞癌免疫调节和合理化治疗方案安排的影响

Scott, Karen J; West, Emma J; Brownlie, Rebecca J; Ismail, Fay; Ralph, Christy; Heineman, Thomas; Coffey, Matt; Melcher, Alan A; Taylor, Alison; Papa, Salvatore; Samson, Adel

Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

作者更正:Palbociclib 和 dsRNA 传感器协同作用,通过内质网应激和免疫逃逸调节增强抗癌作用。

Roulstone, Victoria; Kyula-Currie, Joan; Wright, James; Patin, Emmanuel C; Dean, Isaac; Yu, Lu; Barreiro-Alonso, Aida; Melake, Miriam; Choudhary, Jyoti; Elliott, Richard; Lord, Christopher J; Mansfield, David; Matthews, Nik; Chauhan, Ritika; Jennings, Victoria; Chan Wah Hak, Charleen; Baldock, Holly; Butera, Francesca; Appleton, Elizabeth; Nenclares, Pablo; Pedersen, Malin; Foo, Shane; Wongariyapak, Amarin; Rullan, Antonio; Tenev, Tencho; Meier, Pascal; Vile, Richard; Pandha, Hardev; Melcher, Alan; McLaughlin, Martin; Harrington, Kevin J

PBRM1 directs PBAF to pericentromeres and protects centromere integrity.

PBRM1 将 PBAF 引导至着丝粒周围区域,从而保护着丝粒的完整性

Lane Karen A, Harrod Alison, Wu Lillian, Roumeliotis Theodoros I, Feng Hugang, Foo Shane, Begg Katheryn A G, Schiavoni Federica, Amin Noa, Zenke Frank T, Melcher Alan A, Choudhary Jyoti S, Downs Jessica A

Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial.

通过姑息性放射治疗和 ATR 抑制来控制肿瘤和激活免疫,PATRIOT C 部分:一项 Ib 期试验

Dillon Magnus T, Patin Emmanuel C, Mohammed Kabir, Guevara Jeane, Smith Simon A, Dean Emma, Soliman Heba, Nenclares Pablo, Ryugenji Motoko, Northcote Davina, Shah Neel, Grove Lorna, Lord Christopher J, Pettit Stephen, Tall Matt, Swales Karen E, Banerji Udai, Melcher Alan A, Saunders Mark, Forster Martin D, Harrington Kevin J

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models.

PARP 抑制剂 talazoparib 与呼肠孤病毒协同作用,可在小鼠模型中诱导癌细胞死亡和肿瘤控制

Kyula-Currie Joan, Roulstone Victoria, Wright James, Butera Francesca, Legrand Arnaud, Elliott Richard, McLaughlin Martin, Bozhanova Galabina, Krastev Dragomir, Pettitt Stephen, Tenev Tencho, Dillon Magnus, Foo Shane, Patin Emmanuel C, Jennings Victoria, Chan Wah Hak Charleen, Appleton Elizabeth, Wongariyapak Amarin, Pedersen Malin, Rullan Antonio, Choudhary Jyoti, Bakal Chris, Meier Pascal, Lord Christopher J, Melcher Alan, Harrington Kevin J

Addition of oncolytic virotherapy to clinical isolated limb perfusion for melanoma and sarcoma activates antitumor immunity

在黑色素瘤和肉瘤的临床离体肢体灌注治疗中加入溶瘤病毒疗法可激活抗肿瘤免疫力。

Hayes, Andrew J; Davies, Emma J; Wilkinson, Michelle; Smith, Henry G; Nenclares, Pablo; Lund, Tom; Larkeryd, Adrian; Appleton, Elizabeth; Patin, Emmanuel Christian; Pedersen, Malin; Rullan, Antonio; Mohamed, Hesham S; Aronson, Lauren; Murphy, Jessica; Grove, Lorna; Mansfield, David; Mclaughlin, Martin; Harrington, Kevin J; Melcher, Alan

A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer.

一项 I 期临床试验,研究肝动脉内递送 TG6002 与口服 5-氟胞胞嘧啶联合治疗以肝脏转移为主的结直肠癌患者的疗效

West Emma J, Sadoun Alain, Bendjama Kaidre, Erbs Philippe, Smolenschi Cristina, Cassier Philippe A, de Baere Thierry, Sainte-Croix Sophie, Brandely Maud, Melcher Alan A, Ismail Fay, Scott Karen J, Bennett Angela, Banks Emma, Gasior Ewa, Kent Sarah, Kurzawa Marta, Hammond Christopher, Patel Jai V, Collinson Fiona J, Twelves Chris, Anthoney D Alan, Swinson Dan, Samson Adel

The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer

放射疗法和免疫疗法在激素受体阳性乳腺癌治疗中尚未开发的潜力

Fenton, Matthew; Yoneyama, Miki; Wennerberg, Erik; Lund, Tom; Tutt, Andrew; Melcher, Alan; Demaria, Sandra; Somaiah, Navita