日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5

具有复合物形式限制的共价TRMT112配体,可变构激动METTL5

Goetzke, F Wieland; Bernard, Steffen M; Ju, Cheng-Wei; Pollock, Jonathan; DeMeester, Kristen E; Gross, Jacob; Simon, Gabriel M; He, Chuan; Melillo, Bruno; Cravatt, Benjamin F

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

整合表型筛选和化学蛋白质组学鉴定出调节病毒翻译和复制的 ETF1 配体。

Kim Arthur S, Ma Kevin, Reinhardt Christopher J, Lazar Daniel C, Ogasawara Daisuke, Shaw Teressa M, de la Torre Juan Carlos, Bailey Adam L, Melillo Bruno, Teijaro John R, Cravatt Benjamin F

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.

针对 RNA 结合蛋白 NONO 的共价配体的结构和机制分析。

Lindsey Garrett L, Hockley Thomas K, Gomez Alejandro Villa, Marshall Andrew C, Brothers William R, Finney Colin T, Gross Jacob, Fox Archa H, Yeo Gene W, Melillo Bruno, Bond Charles S, Cravatt Benjamin F

Cysteine Reactivity Profiling Identifies Host Regulators of Mycobacterium tuberculosis Replication in Human Macrophages

半胱氨酸反应性分析揭示人类巨噬细胞中结核分枝杆菌复制的宿主调节因子

Neff, John K; DeMeester, Kristen E; Párraga Solórzano, Paola K; Suciu, Radu M; Dix, Melissa M; Simon, Gabriel; Gianakopoulos, Max A; Melillo, Bruno; Cravatt, Benjamin F; Shiloh, Michael U

A Global Ligandability Map of Tryptoline Butynamide Stereoprobes Identifies Covalent Inhibitors of the Actin Maturation Protease ACTMAP

色氨酸丁酰胺立体探针的全球配体结合能力图谱鉴定出肌动蛋白成熟蛋白酶ACTMAP的共价抑制剂

Xiong, Yijun; Reinhardt, Christopher J; Nguyen, Tracey; Hoffman, Melissa A; Simon, Gabriel M; Melillo, Bruno; Cravatt, Benjamin F

Minimum inoculum of resistance assay for evaluating for anti-toxoplasmosis compounds that target phenyl alanine tRNA synthetase

用于评估靶向苯丙氨酸tRNA合成酶的抗弓形虫化合物的最低接种量抗性测定

Uddin, Taher; Mittal, Payal; Xie, Han; Melillo, Bruno; Sharma, Amit; Chatterjee, Arnab K; Sibley, L David

Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes

通过1-氮杂双环丁烷的应变释放功能化合成对映选择性氮杂环丁烷库

Bielecki, Michael; Nassir, Molhm; Sharma, Hayden A; Truax, Nathanyal J; Raheja, Nicholas; Thompson, Ty M; El-Hayek Ewing, Tamara; Melillo, Bruno; Cravatt, Benjamin F; Baran, Phil S

An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.

利用共价探针通过旁系同源物跃迁定位变构细胞周期蛋白 E-CDK2 位点

Zhang Yuanjin, Liu Zhonglin, Hirschi Marscha, Brodsky Oleg, Johnson Eric, Won Sang Joon, Nagata Asako, Bezwada Divya, Petroski Matthew D, Majmudar Jaimeen D, Niessen Sherry, VanArsdale Todd, Gilbert Adam M, Hayward Matthew M, Stewart Al E, Nager Andrew R, Melillo Bruno, Cravatt Benjamin F

Improved Bicyclic Pyrrolidine Analogues Inhibit Toxoplasma gondii Growth In Vitro and Cure Infection In Vivo

改良的双环吡咯烷类似物在体外抑制弓形虫生长并在体内治愈感染

Uddin, Taher; Xie, Han; Mittal, Payal; Ence, Chloe C; Patil, Shrushti; Sharma, Amit; Melillo, Bruno; Chatterjee, Arnab K; Sibley, L David

SF3B1 thermostability as an assay for splicing inhibitor interactions.

SF3B1 热稳定性作为剪接抑制剂相互作用的检测方法

Amorello Angela N, Chandrashekar Reddy Guddeti, Melillo Bruno, Cravatt Benjamin F, Ghosh Arun K, Jurica Melissa S