Melki Ronald相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts.

从经神经病理学证实的多系统萎缩患者来源的成纤维细胞中生成和表征人类诱导多能干细胞。

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2026.1641981

Alemany-Ribes Mireia, PÃ©rez-Soriano Alexandra, Santos Almudena, Severino Jacqueline, Dangla-Valls AdriÃ, Gigirey-SuÃ¡rez MartÃn, Cohen Dory, Ezquerra Mario, Fernandez-Santiago Ruben, Fernandez Manel, MartÃ Maria J, Baekelandt Veerle, Peelaerts Wouter, Melki Ronald, Compta Yaroslau, Batlle-Morera Laura

发育与干细胞

成纤维细胞

发表日期：2026

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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use

α-突触核蛋白种子扩增检测：临床应用需要数据共享和标准化。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adt7195

Lashuel, Hilal A; Surmeier, D James; Simuni, Tanya; Merchant, Kalpana; Caughey, Byron; Soto, Claudio; Fares, Mohamed-Bilal; Heym, Roland G; Melki, Ronald

发表日期：2025

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Î±-synuclein fibrils per se but not Î±-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons.

α-突触核蛋白原纤维本身，而不是α-突触核蛋白种子聚集，会导致人类神经元线粒体功能障碍和细胞死亡

期刊:Redox Biology

影响因子:11.9

doi:10.1016/j.redox.2025.103817

Angelova Plamena R, Esteras Noemi, Evans James, Kostic Marko, Melki Ronald, Prehn Jochen H M, Gandhi Sonia, Abramov Andrey Y

细胞生物学

发表日期：2025

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Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation

α-突触核蛋白原纤维的结构多态性改变了Hsc70介导的解聚途径

期刊:EMBO Journal

影响因子:8.3

doi:10.1038/s44318-025-00573-3

Jäger, Svenja; Tittelmeier, Jessica; Dang, Thi Lieu; Bellande, Tracy; Redeker, Virginie; Buell, Alexander K; Hennig, Janosch; Melki, Ronald; Nussbaum-Krammer, Carmen; Bukau, Bernd; Wentink, Anne S

发表日期：2025

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In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies.

体内验证新型非侵入性 PHP.eB AAV 作为 α-突触核蛋白病潜在治疗方法。

期刊:Acta Neuropathologica Communications

影响因子:5.7

doi:10.1186/s40478-025-02121-w

Fouka Maria, Tsakogias Iraklis, Gialinaki Elena-Georgia, Stavropoulos Athanasios, Volbracht Christiane, De Muynck Louis, Moechars Diederik, Melki Ronald, Tofaris George K, Stefanis Leonidas, Xilouri Maria

发表日期：2025

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Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole (18)F Probe Targeting α-Synuclein Aggregates

首个靶向α-突触核蛋白聚集体的2-炔基(氮杂)吲哚(18)F探针的设计、合成和评价

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph18111638

Boiaryna, Liliana; Pieri, Laura; Chalon, Sylvie; Serrière, Sophie; Bodard, Sylvie; Chicheri, Gabrielle; Chenaf, Elisa; Suzenet, Franck; Melki, Ronald; Buron, Frédéric; Routier, Sylvain; Vercouillie, Johnny

发表日期：2025

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Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis

α-突触核蛋白在帕金森病发病机制中的作用研究重点

期刊:Movement Disorders

影响因子:7.6

doi:10.1002/mds.29897

Burré, Jacqueline; Edwards, Robert H; Halliday, Glenda; Lang, Anthony E; Lashuel, Hilal A; Melki, Ronald; Murayama, Shigeo; Outeiro, Tiago F; Papa, Stella M; Stefanis, Leonidas; Woerman, Amanda L; Surmeier, Dalton James; Kalia, Lorraine V; Takahashi, Ryosuke

发表日期：2024

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Kinetic models reveal the interplay of protein production and aggregation

动力学模型揭示了蛋白质生成和聚集之间的相互作用

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d4sc00088a

Wei, Jiapeng; Meisl, Georg; Dear, Alexander; Oosterhuis, Matthijs; Melki, Ronald; Emanuelsson, Cecilia; Linse, Sara; Knowles, Tuomas P J

发表日期：2024

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Ligand Profiling as a Diagnostic Tool to Differentiate Patient-Derived α-Synuclein Polymorphs

配体谱分析作为区分患者来源的α-突触核蛋白多态性的诊断工具

期刊:ACS Chemical Neuroscience

影响因子:3.9

doi:10.1021/acschemneuro.4c00178

Chisholm, Timothy S; Melki, Ronald; Hunter, Christopher A

发表日期：2024

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Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us

多系统萎缩症的疾病机制：意大利面的形状与MSA和PD中涉及的α-突触核蛋白组装体之间的相似之处告诉我们什么？

期刊:Cerebellum

影响因子:2.4

doi:10.1007/s12311-022-01417-0

多发性硬化症

发表日期：2024

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