日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tim-3-targeted vaccines overcome tumor immunosuppression and reduce cDC1 dependence to elicit potent anti-tumor immunity

靶向Tim-3的疫苗能够克服肿瘤免疫抑制,并降低对cDC1的依赖性,从而诱导强效的抗肿瘤免疫。

Fu, Chunmei; Ma, Tianle; Clausen, Björn E; Mellman, Ira; Jiang, Aimin

Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

Autogene cevumeran联合或不联合atezolizumab治疗晚期实体瘤:一项I期试验

Lopez, Juanita; Powles, Thomas; Braiteh, Fadi; Siu, Lillian L; LoRusso, Patricia; Friedman, Claire F; Balmanoukian, Ani S; Gordon, Michael; Yachnin, Jeffrey; Rottey, Sylvie; Karydis, Ioannis; Fisher, George A; Schmidt, Marcus; Schuler, Martin; Sullivan, Ryan J; Burris, Howard A; Galvao, Vladimir; Henick, Brian S; Dirix, Luc; Jaeger, Dirk; Ott, Patrick A; Wong, Kit Man; Jerusalem, Guy; Schiza, Aglaia; Fong, Lawrence; Steeghs, Neeltje; Leidner, Rom S; Rittmeyer, Achim; Laurie, Scott A; Gort, Eelke; Aljumaily, Raid; Melero, Ignacio; Sabado, Rachel L; Rhee, Ina; Mancuso, Michael R; Muller, Lars; Fine, Gregg D; Yadav, Mahesh; Kim, Leesun; Leveque, Vincent J P; Robert, Alberto; Darwish, Martine; Qi, Ting; Zhu, Jiawen; Zhang, Jingbin; Twomey, Patrick; Rao, Gautham K; Low, Donald W; Petry, Chris; Lo, Amy A; Schartner, Jill M; Delamarre, Lélia; Mellman, Ira; Löwer, Martin; Müller, Felicitas; Derhovanessian, Evelyna; Cortini, Andrea; Manning, Luisa; Maurus, Daniel; Brachtendorf, Sebastian; Lörks, Verena; Omokoko, Tana; Godehardt, Eva; Becker, Dirk; Hawner, Christine; Wallrapp, Christine; Albrecht, Christian; Kröner, Christoph; Tadmor, Arbel D; Diekmann, Jan; Vormehr, Mathias; Jork, Anette; Paruzynski, Anna; Lang, Maren; Blake, Jonathon; Hennig, Oliver; Kuhn, Andreas N; Sahin, Ugur; Türeci, Özlem; Camidge, D Ross

RNA neoantigen vaccines prime long-lived CD8(+) T cells in pancreatic cancer

RNA新抗原疫苗可激活胰腺癌中的长寿命CD8(+) T细胞

Sethna, Zachary; Guasp, Pablo; Reiche, Charlotte; Milighetti, Martina; Ceglia, Nicholas; Patterson, Erin; Lihm, Jayon; Payne, George; Lyudovyk, Olga; Rojas, Luis A; Pang, Nan; Ohmoto, Akihiro; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Bruno, Emmanuel M; Zhang, Siqi Linsey; Cheng, Charlotte; Elhanati, Yuval; Derhovanessian, Evelyna; Manning, Luisa; Müller, Felicitas; Rhee, Ina; Yadav, Mahesh; Merghoub, Taha; Wolchok, Jedd D; Basturk, Olca; Gönen, Mithat; Epstein, Andrew S; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M; Won, Elizabeth; Desai, Avni; Wei, Alice C; D'Angelica, Michael I; Kingham, T Peter; Soares, Kevin C; Jarnagin, William R; Drebin, Jeffrey; O'Reilly, Eileen M; Mellman, Ira; Sahin, Ugur; Türeci, Özlem; Greenbaum, Benjamin D; Balachandran, Vinod P

Clonal hematopoiesis is associated with reduced response to atezolizumab in non-small cell lung cancer

克隆性造血与非小细胞肺癌患者对阿特珠单抗的反应降低有关

Chat, Vylyny; Fletez-Brant, Kipper; Srivastava, Minu; Nabet, Barzin; Mellman, Ira; McCarthy, Mark I; Hammer, Christian

Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer

不同的PD-L1检测方法揭示了尿路上皮癌中不同的免疫生物学和临床结果

Matthew D Galsky ,Mark Kockx ,Juliette Roels ,Roos Van Elzen ,Xiangnan Guan ,Kobe Yuen ,Deepali Rishipathak ,Jonathan F Anker ,Sacha Gnjatic ,Sudeh Izadmehr ,Shomyseh Sanjabi ,Robert J Johnston ,Maureen Peterson ,Hartmut Koeppen ,Justin M David ,Saurabh Gupta ,Aristotelis Bamias ,Jose Angel Arranz ,Eiji Kikuchi ,Maria De Santis ,Ian D Davis ,Patrick Williams ,Sandrine Bernhard ,Ira Mellman ,Enrique Grande ,Romain Banchereau ,Sanjeev Mariathasan

Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T(reg) cells

出版商更正:抗TIGIT抗体通过髓系细胞和T(reg)细胞增强PD-L1阻断作用

Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y; Silva, John; McGinnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S; Meng, Raymond; Chiang, Eugene Y; Johnston, Robert J; Patil, Namrata S

Author Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T(reg) cells

作者更正:抗TIGIT抗体通过髓系细胞和T(reg)细胞增强PD-L1阻断作用

Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y; Silva, John; McGinnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S; Meng, Raymond; Chiang, Eugene Y; Johnston, Robert J; Patil, Namrata S

TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation

TIGIT 和 PD-L1 联合阻断通过促进共刺激,促进多能、未耗竭的抗肿瘤 T 细胞的克隆扩增。

Nutsch, Katherine; Banta, Karl L; Wu, Thomas D; Tran, Charles W; Mittman, Stephanie; Duong, Ellen; Nabet, Barzin Y; Qu, Yan; Williams, Katherine; Müller, Sören; Patil, Namrata S; Chiang, Eugene Y; Mellman, Ira

HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics

HPK1柠檬酸同源结构域调节SLP76的磷酸化并调控激酶结构域相互作用动力学

Avantika S Chitre,Ping Wu,Benjamin T Walters,Xiangdan Wang,Alexandre Bouyssou,Xiangnan Du,Isabelle Lehoux,Rina Fong,Alisa Arata,Joyce Chan,Die Wang,Yvonne Franke,Jane L Grogan,Ira Mellman,Laetitia Comps-Agrar,Weiru Wang

Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage

核苷酸修饰可通过阻断 RNase 切割来合理设计 TLR7 选择性配体

Ann-Jay Tong #, Rebecca Leylek #, Anna-Maria Herzner #, Diamanda Rigas, Sara Wichner, Craig Blanchette, Siri Tahtinen, Christopher C Kemball, Ira Mellman, Benjamin Haley, Emily C Freund #, Lélia Delamarre #