日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Garcia Sanchez, Mariana; Kim, Ho Min; Vázquez Torres, Susana; Chan, Sidney; Sun, Shirley M; Spear, Timothy T; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE)

泛素连接酶Nedd4-1(NE)对NF-κB通路的负调控

Persaud, Avinash; Kefalas, George; Shteiman, Alina; Priya, Amulya; Liang, Huazhu; Melnyk, Roman A; Astori, Audrey; Raught, Brian; Rotin, Daniela

De novo design of potent inhibitors of clostridial family toxins

从头设计高效梭菌毒素抑制剂

Ragotte, Robert J; Liang, Huazhu; Tam, John; Miletic, Sean; Berman, Jacob M; Palou, Roger; Weidle, Connor; Li, Zhijie; Glögl, Matthias; Beilhartz, Greg L; Carr, Kenneth D; Borst, Andrew J; Coventry, Brian; Wang, Xinru; Rubinstein, John L; Tyers, Mike; Schramek, Daniel; Melnyk, Roman A; Baker, David

Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling.

利用邻近依赖性生物素标记法绘制艰难梭菌TcdB与宿主细胞表面和细胞内因子的相互作用图谱

Ward Jennifer S, Schreiber Karl J, Tam John, Youn Ji-Young, Melnyk Roman A

Atomically accurate de novo design of antibodies with RFdiffusion

利用射频扩散技术进行原子级精确的抗体从头设计

Bennett, Nathaniel R; Watson, Joseph L; Ragotte, Robert J; Borst, Andrew J; See, DéJenaé L; Weidle, Connor; Biswas, Riti; Yu, Yutong; Shrock, Ellen L; Ault, Russell; Leung, Philip J Y; Huang, Buwei; Goreshnik, Inna; Tam, John; Carr, Kenneth D; Singer, Benedikt; Criswell, Cameron; Wicky, Basile I M; Vafeados, Dionne; Sanchez, Mariana Garcia; Kim, Ho Min; Torres, Susana Vázquez; Chan, Sidney; Sun, Shirley M; Spear, Timothy; Sun, Yi; O'Reilly, Keelan; Maris, John M; Sgourakis, Nikolaos G; Melnyk, Roman A; Liu, Chang C; Baker, David

Large Clostridial Toxins: Mechanisms and Roles in Disease

大分子梭菌毒素:机制及其在疾病中的作用

Orrell, Kathleen E; Melnyk, Roman A

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.

药物筛选发现来氟米特可用于治疗由 TTC7A 缺乏引起的炎症性肠病

Jardine Sasha, Anderson Sierra, Babcock Stephen, Leung Gabriella, Pan Jie, Dhingani Neel, Warner Neil, Guo Conghui, Siddiqui Iram, Kotlarz Daniel, Dowling James J, Melnyk Roman A, Snapper Scott B, Klein Christoph, Thiagarajah Jay R, Muise Aleixo M

The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus.

艰难梭菌毒素 B 膜转运机制是一种进化上保守的蛋白质递送装置

Orrell Kathleen E, Mansfield Michael J, Doxey Andrew C, Melnyk Roman A

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

bioPROTACs 作为细胞内治疗靶点(包括增殖细胞核抗原 (PCNA))的多功能调节剂

Lim, Shuhui; Khoo, Regina; Peh, Khong Ming; Teo, Jinkai; Chang, Shih Chieh; Ng, Simon; Beilhartz, Greg L; Melnyk, Roman A; Johannes, Charles W; Brown, Christopher J; Lane, David P; Henry, Brian; Partridge, Anthony W

An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

一种经基因工程改造的嵌合毒素,能够切割活化的突变型和野生型RAS蛋白,从而抑制肿瘤生长。

Vidimar, Vania; Beilhartz, Greg L; Park, Minyoung; Biancucci, Marco; Kieffer, Matthew B; Gius, David R; Melnyk, Roman A; Satchell, Karla J F