日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Computationally informed point of departure evaluation for proarrhythmic cardiotoxicity assessment using 3D engineered cardiac microtissues from human iPSC-derived cardiomyocytes

利用源自人类iPSC的3D工程化心脏微组织，通过计算方法评估促心律失常心脏毒性的出发点

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfaf094
Daley, Mark C; Bronk, Peter; Kim, Tae Yun; Soepriatna, Arvin H; Tran, Cao T; Mende, Ulrike; Coulombe, Kareen L K; Choi, Bum-Rak
3D/类器官
毒理研究
发表日期：2025
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In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment.

从体外到体内，利用 3D hiPSC 衍生的心脏微组织和基于生理的药代动力学模型，为下一代心律失常风险评估提供信息

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfae079
Daley Mark C, Moreau Marjory, Bronk Peter, Fisher Jeffrey, Kofron Celinda M, Mende Ulrike, McMullen Patrick, Choi Bum-Rak, Coulombe Kareen
其它
发表日期：2024
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Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues

利用光学映射的hiPSC衍生3D心脏微组织进行心脏毒性测试的动作电位指标和自动化数据分析流程

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0280406
Soepriatna, Arvin H; Navarrete-Welton, Allison; Kim, Tae Yun; Daley, Mark C; Bronk, Peter; Kofron, Celinda M; Mende, Ulrike; Coulombe, Kareen L K; Choi, Bum-Rak
毒理研究
3D/类器官
发表日期：2023
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Mitochondrial Ca (2+) uniporter (MCU) variants form plasma-membrane channels

线粒体Ca(2+)单向转运蛋白(MCU)变体形成质膜通道

期刊:
影响因子:
doi:10.1101/2023.07.31.551242
Polina, Iuliia; Mishra, Jyotsna; Cypress, Michael W; Landherr, Maria; Valkov, Nedyalka; Chaput, Isabel; Nieto, Bridget; Mende, Ulrike; Zhang, Peng; Jhun, Bong Sook; O-Uchi, Jin
MCU
线粒体
发表日期：2023
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Cardioprotective effects of early intervention with sacubitril/valsartan on pressure overloaded rat hearts

早期应用沙库巴曲/缬沙坦对压力负荷过重大鼠心脏的心脏保护作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-021-95988-3
Li, Xiaofei; Braza, Julie; Mende, Ulrike; Choudhary, Gaurav; Zhang, Peng
Rat
发表日期：2021
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Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes

蛋白激酶D激活可诱导心肌细胞线粒体断裂和功能障碍

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP275418
Jhun, Bong Sook; O-Uchi, Jin; Adaniya, Stephanie M; Mancini, Thomas J; Cao, Jessica L; King, Michelle E; Landi, Amy K; Ma, Hanley; Shin, Milla; Yang, Donqin; Xu, Xiaole; Yoon, Yisang; Choudhary, Gaurav; Clements, Richard T; Mende, Ulrike; Sheu, Shey-Shing
信号转导
线粒体
细胞生物学
发表日期：2018
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In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

利用体外心脏微环境模型研究心肌细胞与非心肌细胞间的相互作用：超越聚苯乙烯培养皿的仿生方法

期刊:Journal of Physiology-London
影响因子:4.4
doi:10.1113/JP273100
Kofron, Celinda M; Mende, Ulrike
细胞生物学
发表日期：2017
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Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart

异源三聚体G蛋白介导的信号传导及其在心脏中的非经典调控

期刊:Life Sciences
影响因子:5.1
doi:10.1016/j.lfs.2015.02.029
Zhang, Peng; Kofron, Celinda M; Mende, Ulrike
信号转导
发表日期：2015
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Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart

G蛋白信号调节因子2在心脏中的功能作用、调控机制及治疗潜力

期刊:Trends in Cardiovascular Medicine
影响因子:9
doi:10.1016/j.tcm.2013.07.002
Zhang, Peng; Mende, Ulrike
信号转导
发表日期：2014
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Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice

尼可地尔可预防转基因小鼠中由Gαq诱导的进行性心力衰竭和室性心律失常

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0052667
Hirose, Masamichi; Takeishi, Yasuchika; Nakada, Tsutomu; Shimojo, Hisashi; Kashihara, Toshihide; Nishio, Ayako; Suzuki, Satoshi; Mende, Ulrike; Matsumoto, Kiyoshi; Matsushita, Naoko; Taira, Eiichi; Sato, Fumika; Yamada, Mitsuhiko
心血管
心力衰竭
发表日期：2012
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