日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.

血管加压素 V2 受体的非活性结构揭示了托伐普坦和曼巴奎汀毒素的不同结合模式

Fouillen Aurélien, Bous Julien, Couvineau Pierre, Orcel Hélène, Mary Charline, Lafleur Lucie, Pierre Timothé, Mendre Christiane, Gilles Nicolas, Schulte Gunnar, Granier Sébastien, Mouillac Bernard

A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases

一种用于治疗低钠血症和多囊肾病的蛇毒衍生物

Stanajic-Petrovic, Goran; Keck, Mathilde; Barbe, Peggy; Urman, Apolline; Correia, Evelyne; Isnard, Pierre; Duong Van Huyen, Jean-Paul; Chmeis, Khawla; Diarra, Sékou Siramakan; Palea, Stefano; Theodoro, Frederic; Nguyen, Anvi-Laëtitia; Castelli, Florence; Pruvost, Alain; Zhao, Wenchao; Mendre, Christiane; Mouillac, Bernard; Bienaimé, Frank; Robin, Philippe; Kessler, Pascal; Llorens-Cortes, Catherine; Servent, Denis; Nozach, Hervé; Maillère, Bernard; Guo, Dong; Truillet, Charles; Gilles, Nicolas

Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies.

通过分子动力学模拟、核磁共振和药理学研究探究加压素 V2 受体的偏向性激活

Fouillen Aurélien, Couvineau Pierre, Gaibelet Gérald, Riché Stéphanie, Orcel Hélène, Mendre Christiane, Kanso Ali, Lanotte Romain, Nguyen Julie, Dimon Juliette, Urbach Serge, Sounier Rémy, Granier Sébastien, Bonnet Dominique, Cong Xiaojing, Mouillac Bernard, Déméné Hélène

Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus

AVP V2受体的偏向性激动剂药理伴侣可能用于治疗先天性肾性尿崩症

Jean-Alphonse, Frédéric; Perkovska, Sanja; Frantz, Marie-Céline; Durroux, Thierry; Méjean, Catherine; Morin, Denis; Loison, Stéphanie; Bonnet, Dominique; Hibert, Marcel; Mouillac, Bernard; Mendre, Christiane

The constitutively active V2 receptor mutants conferring NSIAD are weakly sensitive to agonist and antagonist regulation

构成性激活的V2受体突变体赋予NSIAD,其对激动剂和拮抗剂的调节敏感性较弱。

Tenenbaum, Julie; Ayoub, Mohammed A; Perkovska, Sanja; Adra-Delenne, Anne-Laure; Mendre, Christiane; Ranchin, Bruno; Bricca, Giamperro; Geelen, Ghislaine; Mouillac, Bernard; Durroux, Thierry; Morin, Denis