日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinctive In Vitro Phenotypes in iPSC-Derived Neurons From Patients With Gain- and Loss-of-Function SCN2A Developmental and Epileptic Encephalopathy

患有 SCN2A 功能获得和丧失的发育性癫痫性脑病患者的 iPSC 衍生神经元具有独特的体外表型

Miaomiao Mao, Cristiana Mattei, Ben Rollo, Sean Byars, Claire Cuddy, Geza Berecki, Jacqueline Heighway, Svenja Pachernegg, Trevelyan Menheniott, Danielle Apted, Linghan Jia, Kelley Dalby, Alex Nemiroff, Saul Mullen, Christopher A Reid, Snezana Maljevic, Steven Petrou

Targeting Host Sulphonyl Urea Receptor 2 Can Reduce Severity of Helicobacter pylori Associated Gastritis

靶向宿主磺酰脲受体 2 可降低幽门螺杆菌相关胃炎的严重程度

Sohinee Sarkar, Ghazal Alipour Talesh, Trevelyan R Menheniott, Philip Sutton

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

脉络丛衍生的细胞外囊泡表现出脑靶向特性

Marie J Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R Menheniott, Oskar Gustafsson, Francis Combes, Samir El Andaloussi, Niek N Sanders, Imre Mäger, Lien Van Hoecke, Roosmarijn E Vandenbroucke

IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells

IL-33 与炎症髓系细胞的激活和募集协同促进胃肿瘤生长

Chau P Tran, Michelle Scurr, Louise O'Connor, Jon N Buzzelli, Garrett Z Ng, Sharleen Chung Nien Chin, Lincon A Stamp, Toshinari Minamoto, Andrew S Giraud, Louise M Judd, Philip Sutton, Trevelyan R Menheniott

Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer

通过糖皮质激素反应增强子的损伤导致胃癌中 GKN1 和 GKN2 的协调表达丧失

Sharleen Chung Nien Chin, Louise O'Connor, Michelle Scurr, Jonathan T Busada, Alison N Graham, Ghazal Alipour Talesh, Chau P Tran, Sohinee Sarkar, Toshinari Minamoto, Andrew S Giraud, John A Cidlowski, Philip Sutton, Trevelyan R Menheniott

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations

IL-11 过度表达促进癌前胃上皮增生,与种系 gp130-JAK-STAT 驱动突变无关

Jon N Buzzelli, Louise O'Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z Ng, Masanobu Oshima, Hiroko Oshima, Andrew S Giraud, Philip Sutton, Louise M Judd, Trevelyan R Menheniott

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

胃泌素-2的缺失会驱动癌前胃炎症和肿瘤进展。

Trevelyan R Menheniott, Louise O'Connor, Yok Teng Chionh, Jan Däbritz, Michelle Scurr, Benjamin N Rollo, Garrett Z Ng, Shelley Jacobs, Angelique Catubig, Bayzar Kurklu, Stephen Mercer, Toshinari Minamoto, David E Ong, Richard L Ferrero, James G Fox, Timothy C Wang, Philip Sutton, Louise M Judd, Andrew S Giraud

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice

IL-33 表达升高与儿童嗜酸细胞性食管炎相关,外源性 IL-33 促进小鼠嗜酸细胞性食管炎发展

L M Judd, R G Heine, T R Menheniott, J Buzzelli, N O'Brien-Simpson, D Pavlic, L O'Connor, K Al Gazali, O Hamilton, M Scurr, A M Collison, J Mattes, K J Allen, A S Giraud

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

gp130信号通路的改变可通过髓系细胞特异性STAT3激活和髓系来源的抑制细胞改善实验性结肠炎。

Jan Däbritz ,Louise M Judd ,Heather V Chalinor ,Trevelyan R Menheniott ,Andrew S Giraud

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

差异基因组印记调节 IGF2 在小鼠成年神经发生中的旁分泌和自分泌作用

S R Ferrón, E J Radford, A Domingo-Muelas, I Kleine, A Ramme, D Gray, I Sandovici, M Constancia, A Ward, T R Menheniott, A C Ferguson-Smith