日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

通过优化三环喹啉酮发现一种用于抑制BCL6的体内化学探针

Harnden, Alice C; Davis, Owen A; Box, Gary M; Hayes, Angela; Johnson, Louise D; Henley, Alan T; de Haven Brandon, Alexis K; Valenti, Melanie; Cheung, Kwai-Ming J; Brennan, Alfie; Huckvale, Rosemary; Pierrat, Olivier A; Talbot, Rachel; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; de Klerk, Selby; McAndrew, Peter Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

优化形状互补性有助于发现高效的三环BCL6抑制剂

Davis, Owen A; Cheung, Kwai-Ming J; Brennan, Alfie; Lloyd, Matthew G; Rodrigues, Matthew J; Pierrat, Olivier A; Collie, Gavin W; Le Bihan, Yann-Vaï; Huckvale, Rosemary; Harnden, Alice C; Varela, Ana; Bright, Michael D; Eve, Paul; Hayes, Angela; Henley, Alan T; Carter, Michael D; McAndrew, P Craig; Talbot, Rachel; Burke, Rosemary; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Meniconi, Mirco; Bellenie, Benjamin R; Hoelder, Swen

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

提高结合亲和力和药代动力学可实现体内BCL6的持续降解

Huckvale, Rosemary; Harnden, Alice C; Cheung, Kwai-Ming J; Pierrat, Olivier A; Talbot, Rachel; Box, Gary M; Henley, Alan T; de Haven Brandon, Alexis K; Hallsworth, Albert E; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; Hayes, Angela; Gunnell, Emma A; Brennan, Alfie; Davis, Owen A; Johnson, Louise D; de Klerk, Selby; McAndrew, Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

canSAR chemistry registration and standardization pipeline

canSAR 化学物质注册和标准化流程

Dolciami, Daniela; Villasclaras-Fernandez, Eloy; Kannas, Christos; Meniconi, Mirco; Al-Lazikani, Bissan; Antolin, Albert A

Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

深入探索:通过向溶剂化口袋生长来优化 BCL6 抑制剂

Lloyd, Matthew G; Huckvale, Rosemary; Cheung, Kwai-Ming J; Rodrigues, Matthew J; Collie, Gavin W; Pierrat, Olivier A; Gatti Iou, Mahad; Carter, Michael; Davis, Owen A; McAndrew, P Craig; Gunnell, Emma; Le Bihan, Yann-Vaï; Talbot, Rachel; Henley, Alan T; Johnson, Louise D; Hayes, Angela; Bright, Michael D; Raynaud, Florence I; Meniconi, Mirco; Burke, Rosemary; van Montfort, Rob L M; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

基于片段的筛选可识别靶向 tankyrase 底物结合锚蛋白重复结构域的分子

Pollock Katie, Liu Manjuan, Zaleska Mariola, Meniconi Mirco, Pfuhl Mark, Collins Ian, Guettler Sebastian