日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological and pre-clinical safety profile of rSIV.F/HN, a hybrid lentiviral vector for cystic fibrosis gene therapy

rSIV.F/HN(一种用于囊性纤维化基因治疗的混合慢病毒载体)的药理学和临床前安全性概况

Moiseenko, Alena; Sinadinos, Anthony; Sergijenko, Ana; Pineault, Kyriel; Saleh, Aarash; Nekola, Konradin; Strang, Nathalie; Eleftheraki, Anastasia; Boyd, A Christopher; Davies, Jane C; Gill, Deborah R; Hyde, Stephen C; McLachlan, Gerry; Rath, Tim; Rothe, Michael; Schambach, Axel; Hobbie, Silke; Schuler, Michael; Maier, Udo; Thomas, Matthew J; Mennerich, Detlev; Schmidt, Manfred; Griesenbach, Uta; Alton, Eric W F W; Kreuz, Sebastian

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

人巨细胞病毒编码的pUS28通过靶向CIITA拮抗CD4+ T细胞识别。

Fabienne Maassen ,Vu Thuy Khanh Le-Trilling ,Luisa Betke ,Thilo Bracht ,Corinna Siegmund ,Malte Bayer ,Benjamin Katschinski ,Antonia Belter ,Tanja Becker ,Denise Mennerich ,Sebastian Voigt ,Lori Frappier ,Barbara Sitek ,Katharina Fleischhauer ,Mirko Trilling

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

E3泛素连接酶DTX3L和去泛素化酶USP28通过相互调节其蛋白水平来精细调控DNA修复。

Daniela Mennerich ,Yashwanth Ashok ,Carlos Vela-Rodríguez ,Heli I Hentilä ,Melanie Rall-Scharpf ,Lisa Wiesmüller ,Renata Prunskaite-Hyyryläinen ,Lari Lehtiö ,Thomas Kietzmann

Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB

泛素特异性蛋白酶 10 通过肌醇多磷酸-4-磷酸酶 IIB 型调节表皮生长因子信号传导来决定结直肠癌的结果

Kateryna Kubaichuk, Timo Seitz, Ulrich Bergmann, Virpi Glumoff, Daniela Mennerich, Thomas Kietzmann

USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes

USP28 通过调节 T 淋巴细胞中的 STAT5 磷酸化和 IL22 产生来保护小鼠肠道炎症的发展

Gwenaëlle Le Menn, Keela Pikkarainen, Daniela Mennerich, Dominika Miroszewska, Thomas Kietzmann, Zhi Chen

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin

Diphyllin 通过抑制蛋白酶 L 和弗林蛋白酶对 SARS-CoV-2 的进入发起双管齐下的攻击

Binli Mao, Vu Thuy Khanh Le-Trilling, Haihuan Tang, Jie Hu, Mona S Schmitz, Kimberly Barbet, Dan Xu, Zhen Wei, Beinu Guo, Denise Mennerich, Chun Yao, Jinxin Liu, Zhenghan Li, Yushun Wan, Xiaoyong Zhang, Kai Wang, Ni Tang, Zebo Yu, Mirko Trilling, Yong Lin2

Protein kinase B/AKT phosphorylates hypoxia-inducible factor-3α1 in response to insulin, promoting cell growth and migration

蛋白激酶B/AKT在胰岛素刺激下磷酸化缺氧诱导因子-3α1,促进细胞生长和迁移。

Tran Vinh Hong Nguyen ,Ulrich Bergmann ,Thomas Kietzmann ,Daniela Mennerich

ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP

内质网应激通过FBXW1A/βTrCP促进缺氧诱导因子的VHL非依赖性降解。

Daniela Mennerich ,Kateryna Kubaichuk ,Ghulam S Raza ,Dominik C Fuhrmann ,Karl-Heinz Herzig ,Bernhard Brüne ,Thomas Kietzmann

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

Obatoclax 通过改变内体酸化和损害组织蛋白酶和弗林蛋白酶活性来抑制 SARS-CoV-2 进入

Binli Mao, Vu Thuy Khanh Le-Trilling, Kai Wang, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang, Ni Tang, Mirko Trilling, Yong Lin

Identification of herbal teas and their compounds eliciting antiviral activity against SARS-CoV-2 in vitro

鉴定在体外对 SARS-CoV-2 具有抗病毒活性的草药茶及其化合物

Vu Thuy Khanh Le-Trilling, Denise Mennerich, Corinna Schuler, Roman Sakson, Julia K Lill, Siva Swapna Kasarla, Dominik Kopczynski, Stefan Loroch, Yulia Flores-Martinez, Benjamin Katschinski, Kerstin Wohlgemuth, Matthias Gunzer, Folker Meyer, Prasad Phapale, Ulf Dittmer, Albert Sickmann, Mirko Trilli