日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Membrane-anchored PrPSc is the trigger for prion synaptotoxicity

膜锚定型PrPSc是朊病毒突触毒性的触发因子

Gatdula, Jean R P; Mercer, Robert C C; Alepuz Guillen, Jose Andres; Vultaggio, Janelle S; Harris, David A

Enhanced lysosomal activity prevents infection with PrP(Sc) and the seeding activity of α-synuclein & tau prions

溶酶体活性增强可阻止 PrP(Sc) 感染以及 α-突触核蛋白和 tau 朊病毒的播散活性。

Mercer, Robert C C; Le, Nhat T T; Mirza-Romero, Nadia A; Orbe, Isabel C; Flaherty, Erin; DeFranco, Joseph P; Lavigna, Giada; Gatdula, Jean R P; Fraser, Douglas G; Sundaravadivelu, Aravind; Vultaggio, Janelle S; Beeler, Aaron B; Chiesa, Roberto; Telling, Glenn C; Harris, David A

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

化学组学流程能够发现朊病毒突触毒性通路和抑制药物

Le, Nhat T T; Mercer, Robert C C; Fang, Cheng; Sundaravadivelu, Aravind; Labadorf, Adam T; Lin, Weiwei; Kwan, Julian; Blum, Benjamin; Emili, Andrew; Harris, David A

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy

利用库鲁病保护性朊病毒蛋白变体G127V的显性负效应作为一种新型治疗策略

Gatdula, Jean R P; Orbe, Isabel C; Tolton, Samantha G; Saunders, Linnea M; Vultaggio, Janelle S; Mercer, Robert C C; Bartz, Jason C; Telling, Glenn C; Eraña, Hasier; Castilla, Joaquín; Harris, David A

Lysosomal Enhancement Prevents Infection with PrP(Sc), α-Synuclein & Tau Prions.

溶酶体增强可预防 PrP(Sc)、α-突触核蛋白和 Tau 朊病毒的感染

Mercer Robert C C, Le Nhat T T, Mirza-Romero Nadia A, Flaherty Erin, DeFranco Joseph P, Lavigna Giada, Orbe Isabel C, Gatdula Jean R P, Fraser Douglas G, Sundaravadivelu Aravind, Vultaggio Janelle S, Beeler Aaron B, Chiesa Roberto, Telling Glenn C, Harris David A

Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease

来自患有遗传性克雅氏病的多代家族的iPSC衍生神经元中突触结构异常

Gojanovich, Aldana D; Le, Nhat T T; Mercer, Robert C C; Park, Seonmi; Wu, Bei; Anane, Alice; Vultaggio, Janelle S; Mostoslavsky, Gustavo; Harris, David A

Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.

Sigma受体配体是强效的抗朊病毒化合物,其作用不依赖于Sigma受体结合

Mercer Robert C C, Le Nhat T T, Fraser Douglas G, Houser Mei C Q, Beeler Aaron B, Harris David A

Mechanisms of prion-induced toxicity

朊病毒诱导毒性的机制

Mercer, Robert C C; Harris, David A

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6

朊病毒蛋白通过二肽基氨肽酶样蛋白6调节Kv4.2复合物介导的A型K+电流

Mercer, Robert C C; Ma, Li; Watts, Joel C; Strome, Robert; Wohlgemuth, Serene; Yang, Jing; Cashman, Neil R; Coulthart, Michael B; Schmitt-Ulms, Gerold; Jhamandas, Jack H; Westaway, David