日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease.

抗 Tau 单克隆抗体 JNJ-63733657 在健康参与者和阿尔茨海默病患者中的 1 期研究

Galpern W R, Triana-Baltzer G, Li L, Van Kolen K, Timmers M, Haeverans K, Janssens L, Kolb H, Nandy P, Aida K, Shimizu H, Mercken M, Sun H

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons

转基因小鼠在神经元中过表达人类APP伦敦突变体,表现出显著的脑淀粉样血管病

Van Dorpe, J; Smeijers, L; Dewachter, I; Nuyens, D; Spittaels, K; Van Den Haute, C; Mercken, M; Moechars, D; Laenen, I; Kuiperi, C; Bruynseels, K; Tesseur, I; Loos, R; Vanderstichele, H; Checler, F; Sciot, R; Van Leuven, F

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

tau蛋白向阿尔茨海默病样状态的转变包括微管结合区上游两个丝氨酸-脯氨酸基序的磷酸化

Biernat, J; Mandelkow, E M; Schröter, C; Lichtenberg-Kraag, B; Steiner, B; Berling, B; Meyer, H; Mercken, M; Vandermeeren, A; Goedert, M; Mandelkow, E