日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

全基因组 CRISPR-Cas9 筛选揭示了通过单态性 MHC I 类相关蛋白 MR1 进行普遍存在的 T 细胞癌症靶向治疗

Michael D Crowther # ,Garry Dolton # ,Mateusz Legut ,Marine E Caillaud ,Angharad Lloyd ,Meriem Attaf ,Sarah A E Galloway ,Cristina Rius ,Colin P Farrell ,Barbara Szomolay ,Ann Ager ,Alan L Parker ,Anna Fuller ,Marco Donia ,James McCluskey ,Jamie Rossjohn ,Inge Marie Svane ,John D Phillips ,Andrew K Sewell

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

CD4+ T 细胞通过共享的 V 基因使用模式和互补的生化特征识别保守的甲型流感病毒表位。

Alexander Greenshields-Watson ,Meriem Attaf ,Bruce J MacLachlan ,Thomas Whalley ,Cristina Rius ,Aaron Wall ,Angharad Lloyd ,Hywel Hughes ,Kathryn E Strange ,Georgina H Mason ,Andrea J Schauenburg ,Sarah L Hulin-Curtis ,James Geary ,Yuan Chen ,Sarah N Lauder ,Kathryn Smart ,Dhanasekaran Vijaykrishna ,Miguel L Grau ,Mikhail Shugay ,Robert Andrews ,Garry Dolton ,Pierre J Rizkallah ,Awen M Gallimore ,Andrew K Sewell ,Andrew J Godkin ,David K Cole

GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope

GPU 加速发现病原体衍生的 T 细胞胰岛素表位分子模拟物

Thomas Whalley, Garry Dolton, Paul E Brown, Aaron Wall, Linda Wooldridge, Hugo van den Berg, Anna Fuller, Jade R Hopkins, Michael D Crowther, Meriem Attaf, Robin R Knight, David K Cole, Mark Peakman, Andrew K Sewell, Barbara Szomolay

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

肽超级激动剂增强 T 细胞对黑色素瘤的反应

Sarah A E Galloway, Garry Dolton, Meriem Attaf, Aaron Wall, Anna Fuller, Cristina Rius, Valentina Bianchi, Sarah Theaker, Angharad Lloyd, Marine E Caillaud, Inge Marie Svane, Marco Donia, David K Cole, Barbara Szomolay, Pierre Rizkallah, Andrew K Sewell

Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

用于检测和分离自身免疫性 T 细胞的优化肽-MHC 多聚体方案

Garry Dolton, Efthalia Zervoudi, Cristina Rius, Aaron Wall, Hannah L Thomas, Anna Fuller, Lorraine Yeo, Mateusz Legut, Sophie Wheeler, Meriem Attaf, Dmitriy M Chudakov, Ernest Choy, Mark Peakman, Andrew K Sewell

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig

在巴布拉罕近交系猪中气溶胶递送疫苗抗原或病毒后在呼吸道中诱导流感特异性局部 CD8 T 细胞

Katie Tungatt, Garry Dolton, Sophie B Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A Hammond, John J Miles, David K Cole, Alain Townsend, Mick Bailey, Pierre J Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K Sewell

Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

肽-MHC I类四聚体可能无法检测到相关的功能性T细胞克隆型,并低估抗原反应性T细胞群。

Cristina Rius ,Meriem Attaf ,Katie Tungatt ,Valentina Bianchi ,Mateusz Legut ,Amandine Bovay ,Marco Donia ,Per Thor Straten ,Mark Peakman ,Inge Marie Svane ,Sascha Ott ,Tom Connor ,Barbara Szomolay ,Garry Dolton ,Andrew K Sewell

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen

分子开关可消除糖蛋白 100 (gp100) T 细胞受体 (TCR) 对人类黑色素瘤抗原的靶向作用

Valentina Bianchi, Anna Bulek, Anna Fuller, Angharad Lloyd, Meriem Attaf, Pierre J Rizkallah, Garry Dolton, Andrew K Sewell, David K Cole

αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivity

αβ T 细胞受体种系 CDR 区调节与 MHC 配体的接触并调节肽交叉反应

Meriem Attaf, Stephan J Holland, Istvan Bartok, Julian Dyson