日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural optimization of drug molecules with incrementally trained language models

利用增量训练的语言模型进行药物分子结构优化

Hörmann, Tim; Mayer, Domenic; Lewandowski, Max; Hunklinger, Andrea; Wein, Thomas; Merk, Daniel

Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery

点击。屏幕。降级。用于快速 PROTAC 发现的微型化 D2B 工作流程

Mitrović, Marko; Greco, Francesco Aleksy; García, Yiliam Cruz; Lučić, Aleksandar; Hoffmann, Lasse; Chander, Rohit; Schönfeld, Julia; Liebisch, Nick; Sivashanmugam, Saran Aswathaman; Schwalm, Martin Peter; Egner, Markus; Lewandowski, Max; Merk, Daniel; Morasch, Viktoria; Wolf, Elmar; Müller, Susanne; Hanke, Thomas; Proschak, Ewgenij; Hiesinger, Kerstin; Knapp, Stefan

Systematic Optimization of Fragment TLX Ligands toward Agonism and Inverse Agonism

系统优化TLX片段配体以实现激动和反向激动作用

Hank, Emily C; Knümann, Loris; López-García, Úrsula; Kardanov, Arthur; Morozov, Vasily; Höfner, Georg; Merk, Daniel

Structural Tuning of Vidofludimus for High-Efficacy NR4A Agonism.

Vidofludimus 的结构调控以实现高效 NR4A 激动作用。

Vietor Jan, Busch Romy, López-García Úrsula, Stiller Tanja, Thommes Anna Maria, Gege Christian, Merk Daniel

Dual Nurr1/RXR agonism of valerenic acid and synthetic mimetics enables dimer-selective Nurr1 modulation

缬草酸及其合成类似物对 Nurr1/RXR 的双重激动作用可实现对二聚体选择性的 Nurr1 调控。

Scholz, Katharina; López-García, Úrsula; Busch, Romy; Marschner, Julian A; Merk, Daniel

Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight

利用低分子量分子靶向SARS-CoV-2 RNA翻译起始元件SL1

Toews, Sabrina; Donà, Francesca; Keller, Marco; Krauß, Jürgen; Bracher, Franz; López-García, Úrsula; Pabel, Jörg; Merk, Daniel; Blommers, Marcel J J; Ferner, Jan; Wacker, Anna; Richter, Christian; Schwalbe, Harald

De Novo Discovery of α,α-Disubstituted α-amino Acid-Containing α-helical Peptides as Competitive PPARγ PPI Inhibitors

从头发现含α,α-二取代α-氨基酸的α-螺旋肽作为竞争性PPARγ PPI抑制剂

Sigal, Maxwell; Egner, Markus; Okada, Chikako; Merk, Daniel; Sengoku, Toru; Katoh, Takayuki; Suga, Hiroaki

Genome-wide CRISPR-Cas9 screens identify BCL family members as modulators of response to regorafenib in experimental glioma

全基因组 CRISPR-Cas9 筛选鉴定出 BCL 家族成员是实验性胶质瘤中瑞戈非尼反应的调节因子

Haeusser, Lara Annina; Becker, Hannes; Kuhlburger, Laurence; Zago, Marcello; Walter, Bianca; Tsiami, Foteini; Erdmann, Sarah; Trampert, Jil; Surender, Surender; Stahl, Aaron; Templin, Markus; Wegner, Eileen; Schmidt, Tobias; Schmees, Christian; Casadei, Nicolas; Sevenich, Lisa; Claassen, Manfred; Nahnsen, Sven; Beck, Susanne; Merk, Daniel Josef; Tabatabai, Ghazaleh

Methodological validation of Miro1 retention as a candidate Parkinson's disease biomarker

Miro1 滞留作为帕金森病候选生物标志物的方法学验证

Drwesh, Layla; Arena, Giuseppe; Merk, Daniel J; Ferrante, Daniele; Gorgogietas, Vyron; Gasser, Thomas; Grünewald, Anne; May, Patrick; Brockmann, Kathrin; Krüger, Rejko; Wüst, Richard; Gloeckner, Christian Johannes; Fitzgerald, Julia C

Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators

利用化学语言模型进行支架融合和构效关系转移,生成新型肝X受体调节剂

Bandomir, Nils Christiaan; Hörmann, Tim; Kärcher, Annette; Kaiser, Astrid; Merk, Daniel; Heitel, Pascal