日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Removal of promoter CpG methylation by epigenome editing reverses HBG silencing

通过表观基因组编辑去除启动子 CpG 甲基化可逆转 HBG 沉默。

Henry W Bell # ,Ruopeng Feng # ,Manan Shah ,Yu Yao ,James Douglas ,Phillip A Doerfler ,Thiyagaraj Mayuranathan ,Michael F O'Dea ,Yichao Li ,Yong-Dong Wang ,Jingjing Zhang ,Joel P Mackay ,Yong Cheng ,Kate G R Quinlan ,Mitchell J Weiss # ,Merlin Crossley #

Potent and uniform fetal hemoglobin induction via base editing

通过碱基编辑实现强效、均匀的胎儿血红蛋白诱导

Thiyagaraj Mayuranathan #, Gregory A Newby #, Ruopeng Feng, Yu Yao, Kalin D Mayberry, Cicera R Lazzarotto, Yichao Li, Rachel M Levine, Nikitha Nimmagadda, Erin Dempsey, Guolian Kang, Shaina N Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Jingjing Chen, Henry W Bell, Merlin Crossley, Se

miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation

miR-365-3p 介导 BCL11A 和 SOX6 红细胞特异性共调节:HbF 激活中的新参与者

Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Cristian Antonio Caria, Lucia Perseu, Manan Shah, Merlin Crossley, Paolo Moi, Maria Serafina Ristaldi

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

HIC2通过抑制BCL11A转录来控制发育过程中的血红蛋白转换。

Peng Huang ,Scott A Peslak ,Ren Ren ,Eugene Khandros ,Kunhua Qin ,Cheryl A Keller ,Belinda Giardine ,Henry W Bell ,Xianjiang Lan ,Malini Sharma ,John R Horton ,Osheiza Abdulmalik ,Stella T Chou ,Junwei Shi ,Merlin Crossley ,Ross C Hardison ,Xiaodong Cheng ,Gerd A Blobel

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression

破坏成人珠蛋白启动子可减轻启动子竞争并重新激活胎儿珠蛋白基因表达

Sarah K Topfer, Ruopeng Feng, Peng Huang, Lana C Ly, Gabriella E Martyn, Gerd A Blobel, Mitchell J Weiss, Kate G R Quinlan, Merlin Crossley

Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin

利用 CRISPR 碱基编辑技术鉴定可提高胎儿血红蛋白表达的新型 HPFH 样突变

Nithin Sam Ravi ,Beeke Wienert ,Stacia K Wyman ,Henry William Bell ,Anila George ,Gokulnath Mahalingam ,Jonathan T Vu ,Kirti Prasad ,Bhanu Prasad Bandlamudi ,Nivedhitha Devaraju ,Vignesh Rajendiran ,Nazar Syedbasha ,Aswin Anand Pai ,Yukio Nakamura ,Ryo Kurita ,Muthuraman Narayanasamy ,Poonkuzhali Balasubramanian ,Saravanabhavan Thangavel ,Srujan Marepally ,Shaji R Velayudhan ,Alok Srivastava ,Mark A DeWitt ,Merlin Crossley ,Jacob E Corn ,Kumarasamypet M Mohankumar

Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter

用于分析锌指转录因子与其同源启动子结合的蛋白质-DNA结合的实验方案

Lana C Ly,Yang Yang,Fudong Li,Merlin Crossley,Yunyu Shi,Kate G R Quinlan

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin

GATA1 和 NF-Y 激活 γ 珠蛋白基因表达在胎儿血红蛋白的遗传持续性中

Phillip A Doerfler, Ruopeng Feng, Yichao Li, Lance E Palmer, Shaina N Porter, Henry W Bell, Merlin Crossley, Shondra M Pruett-Miller, Yong Cheng, Mitchell J Weiss

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

ZNF410 特异性激活 NuRD 组分 CHD4 以抑制胎儿血红蛋白表达

Xianjiang Lan ,Ren Ren ,Ruopeng Feng ,Lana C Ly ,Yemin Lan ,Zhe Zhang ,Nicholas Aboreden ,Kunhua Qin ,John R Horton ,Jeremy D Grevet ,Thiyagaraj Mayuranathan ,Osheiza Abdulmalik ,Cheryl A Keller ,Belinda Giardine ,Ross C Hardison ,Merlin Crossley ,Mitchell J Weiss ,Xiaodong Cheng ,Junwei Shi ,Gerd A Blobel

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

脂肪组织中的嗜酸性粒细胞功能受 Krüppel 样因子 3 (KLF3) 调节

Alexander J Knights, Emily J Vohralik, Peter J Houweling, Elizabeth S Stout, Laura J Norton, Stephanie J Alexopoulos, Jinfen J Yik, Hanapi Mat Jusoh, Ellen M Olzomer, Kim S Bell-Anderson, Kathryn N North, Kyle L Hoehn, Merlin Crossley, Kate G R Quinlan