日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR(+)/HER2(-) breast cancer.

mTOR 驱动的自噬抑制定义了 CDK4/6 抑制剂耐药的 HR(+)/HER2(-) 乳腺癌的代谢脆弱性。

von Wichert Luise, Stroh Alina, Witt Marie, Wanzel Michael, Mernberger Marco, Griewing Sebastian, Wündisch Thomas, Pfitzner Berit M, Teply-Szymanski Julia, Litmeyer Anne-Sophie, Denkert Carsten, Wagner Uwe, Stiewe Thorsten, Gremke Niklas

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

深度 CRISPR 诱变表征了 TP53 突变的功能多样性

Funk Julianne S, Klimovich Maria, Drangenstein Daniel, Pielhoop Ole, Hunold Pascal, Borowek Anna, Noeparast Maxim, Pavlakis Evangelos, Neumann Michelle, Balourdas Dimitrios-Ilias, Kochhan Katharina, Merle Nastasja, Bullwinkel Imke, Wanzel Michael, Elmshäuser Sabrina, Teply-Szymanski Julia, Nist Andrea, Procida Tara, Bartkuhn Marek, Humpert Katharina, Mernberger Marco, Savai Rajkumar, Soussi Thierry, Joerger Andreas C, Stiewe Thorsten

Superior Overall Survival in Patients with Colorectal Cancer, Regular Aspirin Use, and Combined Wild-Type PIK3CA and KRAS-Mutated Tumors

结直肠癌患者规律服用阿司匹林,且肿瘤同时携带野生型PIK3CA和KRAS突变,可显著提高总体生存率。

Gebauer, Leonie; Nist, Andrea; Mernberger, Marco; Stiewe, Thorsten; Moll, Roland; Stabla, Kathleen; Klinge, Uwe; Mack, Elisabeth; Brendel, Cornelia; Neubauer, Andreas

Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy

肿瘤发生后期p53功能的丧失赋予了肿瘤细胞ARF依赖性的对p53再激活疗法的易感性。

Klimovich, Boris; Mutlu, Samet; Schneikert, Jean; Elmshäuser, Sabrina; Klimovich, Maria; Nist, Andrea; Mernberger, Marco; Timofeev, Oleg; Stiewe, Thorsten

Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

MDM2 和 MDMX 基因中 SNP 的特定等位基因变异与白种人乳腺癌患者的肿瘤早期发生和进展相关。

Bauer, Marcus; Kantelhardt, Eva Johanna; Stiewe, Thorsten; Nist, Andrea; Mernberger, Marco; Politt, Katharina; Hanf, Volker; Lantzsch, Tilmann; Uleer, Christoph; Peschel, Susanne; John, Jutta; Buchmann, Jörg; Weigert, Edith; Bürrig, Karl-Friedrich; Wickenhauser, Claudia; Thomssen, Christoph; Bartel, Frank; Vetter, Martina

Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference

与 CTCF 相比,CTCFL 结合位点的选择受染色质和序列偏好性的驱动。

Bergmaier, Philipp; Weth, Oliver; Dienstbach, Sven; Boettger, Thomas; Galjart, Niels; Mernberger, Marco; Bartkuhn, Marek; Renkawitz, Rainer

Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation

致癌性NRAS启动原代急性髓系白血病细胞分化

Brendel, Cornelia; Teichler, Sabine; Millahn, Axel; Stiewe, Thorsten; Krause, Michael; Stabla, Kathleen; Ross, Petra; Huynh, Minh; Illmer, Thomas; Mernberger, Marco; Barckhausen, Christina; Neubauer, Andreas