Merquiol相关文献与解析，生知库 | 链接生命科学的每一步

Development and Application of Small Molecule-Peptide Conjugates as Cathepsin K-Specific Covalent Irreversible Inhibitors in Human Osteoclast and Lung Cancer.

小分子肽缀合物作为组织蛋白酶 K 特异性共价不可逆抑制剂在人类破骨细胞和肺癌中的开发与应用

Dey Gourab, Yakobovich Evalyn, Loboda Jure, Sinai-Turyansky Reut, Abramovitch-Dahan Chen, Merquiol Emmanuelle, Sridharan Nikhila, Itzhak Gal, Turk Boris, Wald Ori, Turk Dusan, Yona Simon, Levaot Noam, Blum Galia

细胞生物学

Novel Nucleus-Oriented Quenched Activity-Based Probes Link Cathepsin Nuclear Localization with Mitosis

新型以核为导向的淬灭活性探针将组织蛋白酶核定位与有丝分裂联系起来

期刊:ACS Sensors

影响因子:8.2

doi:10.1021/acssensors.4c03217

Karin Reut Shannon, Tommy Weiss-Sadan, Emmanuelle Merquiol, Gourab Dey, Tamar Gilon, Boris Turk, Galia Blum

发表日期：2025

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Italian still life paintings as a resource for reconstructing past Mediterranean aquatic biodiversity

意大利静物画作为重建过去地中海水生生物多样性的资源

期刊:npj Biodiversity

影响因子:

doi:10.1038/s44185-025-00103-8

Merquiol, L; Tribot, A-S; Faget, D; Denys, G P J; Richard, T; Changeux, T

发表日期：2025

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Cathepsin B promotes Aβ proteotoxicity by modulating aging regulating mechanisms

组织蛋白酶B通过调节衰老调控机制促进Aβ蛋白毒性。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-024-52540-x

Atif Ahmed Siddiqui ，Emmanuelle Merquiol ，Reut Bruck-Haimson ，Joud Hirbawi ，Hana Boocholez ，Irit Cohen ，Yonghong Yan ，Meng Qiu Dong ，Galia Blum ，Ehud Cohen

Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin-K Activity Detection, Revealing Nuclear Activity

开发和应用可逆和不可逆共价探针检测人和小鼠组织蛋白酶K活性，揭示核活性

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202401518

Dey, Gourab; Sinai-Turyansky, Reut; Yakobovich, Evalyn; Merquiol, Emmanuelle; Loboda, Jure; Sridharan, Nikhila; Houri-Haddad, Yael; Polak, David; Yona, Simon; Turk, Dusan; Wald, Ori; Blum, Galia

Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules

模拟微重力对细胞吸收小分子的不同影响

期刊:Pharmaceutics

影响因子:4.9

doi:10.3390/pharmaceutics16091211

Odelia Tepper-Shimshon, Nino Tetro, Roa'a Hamed, Natalia Erenburg, Emmanuelle Merquiol, Gourab Dey, Agam Haim, Tali Dee, Noa Duvdevani, Talin Kevorkian, Galia Blum, Eylon Yavin, Sara Eyal

Challenges in Batch-to-Bed Translation Involving Inflammation-Targeting Compounds in Chronic Epilepsy: The Case of Cathepsin Activity-Based Probes

慢性癫痫炎症靶向化合物从批次到临床转化面临的挑战：以组织蛋白酶活性探针为例

期刊:ACS Omega

影响因子:4.3

doi:10.1021/acsomega.3c08759

Hamed, Roa'a; Merquiol, Emmanuelle; Zlotver, Ivan; Blum, Galia; Eyal, Sara; Ekstein, Dana

炎症

炎症/感染

Immunology/Inflammation

Jellyfish from Fisheries By-Catches as a Sustainable Source of High-Value Compounds with Biotechnological Applications

渔业兼捕中的水母作为具有生物技术应用的高价值化合物的可持续来源

期刊:Marine Drugs

影响因子:5.4

doi:10.3390/md20040266

D'Ambra, Isabella; Merquiol, Louise

Fish

发表日期：2022

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A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases

基于组织蛋白酶活性的诊断探针，用于心血管疾病的非侵入性干预

期刊:Theranostics

影响因子:12.4

doi:10.7150/thno.34402

Tommy Weiss-Sadan, Yael Ben-Nun, David Maimoun, Emmanuelle Merquiol, Ihab Abd-Elrahman, Israel Gotsman, Galia Blum

信号转导

发表日期：2019

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CD74-Targeted Cathepsin-Inhibitor Antibody-Drug Conjugate Triggers Apoptosis in DLBCL

CD74靶向组织蛋白酶抑制剂抗体药物偶联物可诱导弥漫性大B细胞淋巴瘤细胞凋亡

Development and Application of Small Molecule-Peptide Conjugates as Cathepsin K-Specific Covalent Irreversible Inhibitors in Human Osteoclast and Lung Cancer.

小分子肽缀合物作为组织蛋白酶 K 特异性共价不可逆抑制剂在人类破骨细胞和肺癌中的开发与应用

Novel Nucleus-Oriented Quenched Activity-Based Probes Link Cathepsin Nuclear Localization with Mitosis

新型以核为导向的淬灭活性探针将组织蛋白酶核定位与有丝分裂联系起来

Italian still life paintings as a resource for reconstructing past Mediterranean aquatic biodiversity

意大利静物画作为重建过去地中海水生生物多样性的资源

Cathepsin B promotes Aβ proteotoxicity by modulating aging regulating mechanisms

组织蛋白酶B通过调节衰老调控机制促进Aβ蛋白毒性。

Development and Application of Reversible and Irreversible Covalent Probes for Human and Mouse Cathepsin-K Activity Detection, Revealing Nuclear Activity

开发和应用可逆和不可逆共价探针检测人和小鼠组织蛋白酶K活性，揭示核活性

Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules

模拟微重力对细胞吸收小分子的不同影响

Challenges in Batch-to-Bed Translation Involving Inflammation-Targeting Compounds in Chronic Epilepsy: The Case of Cathepsin Activity-Based Probes

慢性癫痫炎症靶向化合物从批次到临床转化面临的挑战：以组织蛋白酶活性探针为例

Jellyfish from Fisheries By-Catches as a Sustainable Source of High-Value Compounds with Biotechnological Applications

渔业兼捕中的水母作为具有生物技术应用的高价值化合物的可持续来源

A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases

基于组织蛋白酶活性的诊断探针，用于心血管疾病的非侵入性干预