Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified
羰基还原酶1在小鼠肝脏中将阿霉素转化为具有心脏毒性的阿霉素醇的过程中起着重要作用,但大部分阿霉素醇的形成活性仍未被鉴定。
期刊:Drug Metabolism and Disposition
影响因子:4
doi:10.1124/dmd.119.089326
Breysse, Daniel H; Boone, Ryan M; Long, Cameron M; Merrill, Miranda E; Schaupp, Christopher M; White, Collin C; Kavanagh, Terrance J; Schmidt, Edward E; Merrill, Gary F