日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Relapse timing is associated with distinct evolutionary dynamics in DLBCL

复发时机与 DLBCL 的不同进化动态相关

Laura K Hilton, Henry S Ngu, Brett Collinge, Kostiantyn Dreval, Susana Ben-Neriah, Christopher K Rushton, Jasper C H Wong, Manuela Cruz, Andrew Roth, Merrill Boyle, Barbara Meissner, Graham W Slack, Pedro Farinha, Jeffrey W Craig, Alina S Gerrie, Ciara L Freeman, Diego Villa, Michael Crump, Lois She

Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma

肿瘤相关抗原PRAME具有双重功能,可作为弥漫性大B细胞淋巴瘤的治疗靶点。

Katsuyoshi Takata ,Lauren C Chong ,Daisuke Ennishi ,Tomohiro Aoki ,Michael Yu Li ,Avinash Thakur ,Shannon Healy ,Elena Viganò ,Tao Dao ,Daniel Kwon ,Gerben Duns ,Julie S Nielsen ,Susana Ben-Neriah ,Ethan Tse ,Stacy S Hung ,Merrill Boyle ,Sung Soo Mun ,Christopher M Bourne ,Bruce Woolcock ,Adèle Telenius ,Makoto Kishida ,Shinya Rai ,Allen W Zhang ,Ali Bashashati ,Saeed Saberi ,Gianluca D'Antonio ,Brad H Nelson ,Sohrab P Shah ,Pamela A Hoodless ,Ari M Melnick ,Randy D Gascoyne ,Joseph M Connors ,David A Scheinberg ,Wendy Béguelin ,David W Scott ,Christian Steidl

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

TMEM30A 功能丧失突变可驱动淋巴瘤形成,并导致 B 细胞淋巴瘤具有治疗上可利用的脆弱性

Daisuke Ennishi #, Shannon Healy #, Ali Bashashati #, Saeed Saberi, Christoffer Hother, Anja Mottok, Fong Chun Chan, Lauren Chong, Libin Abraham, Robert Kridel, Merrill Boyle, Barbara Meissner, Tomohiro Aoki, Katsuyoshi Takata, Bruce W Woolcock, Elena Viganò, Michael Gold, Laurie L Molday, Robert S

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

弥漫性大 B 细胞淋巴瘤中体细胞调控变异的全基因组发现

Sarah E Arthur, Aixiang Jiang, Bruno M Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K Rushton, Anja Mottok, Laura K Hilton, Prince Kumar Lat, Eric Y Zhao, Luka Culibrk, Daisuke Ennishi, Selin Jessa, Lauren Chong, Nicole Thomas, Prasath Pararajalingam, Barbara Meissner, Merrill Boyle, Jordan

The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy

MCL35 基因表达增殖检测可预测接受强化一线治疗的挪威年轻患者群体中存在高风险 MCL 患者

Harald Holte, Klaus Beiske, Merrill Boyle, Gunhild Trøen, Yngvild N Blaker, June Myklebust, Sunniva Kvaløy, Andreas Rosenwald, Ole C Lingjaerde, Lisa M Rimsza, Erlend B Smeland, David W Scott, Arne Kolstad

New Molecular Assay for the Proliferation Signature in Mantle Cell Lymphoma Applicable to Formalin-Fixed Paraffin-Embedded Biopsies

适用于福尔马林固定石蜡包埋活检的套细胞淋巴瘤增殖特征的新分子检测

David W Scott, Pau Abrisqueta, George W Wright, Graham W Slack, Anja Mottok, Diego Villa, Pedro Jares, Hilka Rauert-Wunderlich, Cristina Royo, Guillem Clot, Magda Pinyol, Merrill Boyle, Fong Chun Chan, Rita M Braziel, Wing C Chan, Dennis D Weisenburger, James R Cook, Timothy C Greiner, Kai Fu, Germa

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression

CIITA 基因变异在原发性纵隔大 B 细胞淋巴瘤中很常见,且与 MHC II 类表达减少有关

Anja Mottok, Bruce Woolcock, Fong Chun Chan, King Mong Tong, Lauren Chong, Pedro Farinha, Adèle Telenius, Elizabeth Chavez, Suvan Ramchandani, Marie Drake, Merrill Boyle, Susana Ben-Neriah, David W Scott, Lisa M Rimsza, Reiner Siebert, Randy D Gascoyne, Christian Steidl

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma

原发性纵隔 B 细胞淋巴瘤和霍奇金淋巴瘤中的 PTPN1 复发性体细胞突变

Jay Gunawardana, Fong Chun Chan, Adèle Telenius, Bruce Woolcock, Robert Kridel, King L Tan, Susana Ben-Neriah, Anja Mottok, Raymond S Lim, Merrill Boyle, Sanja Rogic, Lisa M Rimsza, Chrystelle Guiter, Karen Leroy, Philippe Gaulard, Corinne Haioun, Marco A Marra, Kerry J Savage, Joseph M Connors, Soh

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

EZH2 Y641 体细胞突变主要通过选择性改变 PRC2 催化活性的机制起作用,从而增加 H3K27 三甲基化

Damian B Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S-W Grace Cheng, Annie Moradian, Ryan D Morin, Andrew J Mungall, Barbara Meissner, Merrill Boyle, Victor E Marquez, Marco A Marra, Randy D Gascoyne, R Keith Humphries, Cheryl H Arrowsmith, Gregg B Morin, Samuel A J R Aparicio

Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival

弥漫性大 B 细胞淋巴瘤:CD20 表达降低与生存率较低相关

Nathalie A Johnson, Merrill Boyle, Ali Bashashati, Stephen Leach, Angela Brooks-Wilson, Laurie H Sehn, Mukesh Chhanabhai, Ryan R Brinkman, Joseph M Connors, Andrew P Weng, Randy D Gascoyne