日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

人类 CLC-2 电压门控氯离子通道的 CryoEM 结构揭示了球链门控机制

Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

人类 CLC-2 电压门控氯离子通道的 CryoEM 结构揭示了球链门控机制

Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

LRRC8A:C/E 异源通道是 cGAMP 的普遍转运体

Lauren J Lahey, Rachel E Mardjuki, Xianlan Wen, Gaelen T Hess, Christopher Ritchie, Jacqueline A Carozza, Volker Böhnert, Merritt Maduke, Michael C Bassik, Lingyin Li

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl-/H+ transport cycle

CLC-ec1突变体揭示了整体构象变化,并提示了CLC Cl-/H+转运循环的统一机制。

Tanmay S Chavan # ,Ricky C Cheng # ,Tao Jiang ,Irimpan I Mathews ,Richard A Stein ,Antoine Koehl ,Hassane S Mchaourab ,Emad Tajkhorshid ,Merritt Maduke

Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporter

揭示 CLC Cl(-)/H(+) 交换转运体中向外开放的构象状态

Chandra M Khantwal, Sherwin J Abraham, Wei Han, Tao Jiang, Tanmay S Chavan, Ricky C Cheng, Shelley M Elvington, Corey W Liu, Irimpan I Mathews, Richard A Stein, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke

13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1

13C NMR 检测 100 kD 膜转运蛋白 ClC-ec1 的构象变化

Sherwin J Abraham, Ricky C Cheng, Thomas A Chew, Chandra M Khantwal, Corey W Liu, Shimei Gong, Robert K Nakamoto, Merritt Maduke

Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule

ClC-0 中的半胱氨酸可及性支持 ClC 细胞内前庭的保护

Anita M Engh, Merritt Maduke