日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation

一项全基因组扰动筛选实验表明,核糖核蛋白Hnrnpk是朊病毒传播的限速因子。

Merve Avar #,Daniel Heinzer #,Alana M Thackray,Yingjun Liu,Marian Hruska-Plochan,Stefano Sellitto,Elke Schaper,Daniel P Pease,Jiang-An Yin,Asvin Kk Lakkaraju,Marc Emmenegger,Marco Losa,Andra Chincisan,Simone Hornemann,Magdalini Polymenidou,Raymond Bujdoso,Adriano Aguzzi

Scaling analysis reveals the mechanism and rates of prion replication in vivo

缩放分析揭示了朊病毒在体内复制的机制和速率

Georg Meisl #, Timothy Kurt #, Itzel Condado-Morales #, Cyrus Bett, Silvia Sorce, Mario Nuvolone, Thomas C T Michaels, Daniel Heinzer, Merve Avar, Samuel I A Cohen, Simone Hornemann, Adriano Aguzzi, Christopher M Dobson, Christina J Sigurdson, Tuomas P J Knowles

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

LAG3在人和小鼠的神经元中均不表达,也不调节α-突触核蛋白病。

Marc Emmenegger,Elena De Cecco,Marian Hruska-Plochan,Timo Eninger,Matthias M Schneider,Melanie Barth,Elena Tantardini,Pierre de Rossi,Mehtap Bacioglu,Rebekah G Langston,Alice Kaganovich,Nora Bengoa-Vergniory,Andrès Gonzalez-Guerra,Merve Avar,Daniel Heinzer,Regina Reimann,Lisa M Häsler,Therese W Herling,Naunehal S Matharu,Natalie Landeck,Kelvin Luk,Ronald Melki,Philipp J Kahle,Simone Hornemann,Tuomas P J Knowles,Mark R Cookson,Magdalini Polymenidou,Mathias Jucker,Adriano Aguzzi

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein

采用综合基因组学方法剖析调控 α-突触核蛋白细胞间转移的遗传图谱

Eleanna Kara, Alessandro Crimi, Anne Wiedmer, Marc Emmenegger, Claudia Manzoni, Sara Bandres-Ciga, Karishma D'Sa, Regina H Reynolds, Juan A Botía, Marco Losa, Veronika Lysenko, Manfredi Carta, Daniel Heinzer, Merve Avar, Andra Chincisan, Cornelis Blauwendraat, Sonia García-Ruiz, Daniel Pease, Lorene

High content genome-wide siRNA screen to investigate the coordination of cell size and RNA production

高内涵全基因组 siRNA 筛选,用于研究细胞大小与 RNA 生成的协调性

Micha Müller, Merve Avar, Daniel Heinzer, Marc Emmenegger, Adriano Aguzzi, Lucas Pelkmans, Scott Berry

Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

全基因组RNA干扰揭示PrPC生物合成的新型调控因子

Daniel Heinzer,Merve Avar,Daniel Patrick Pease,Ashutosh Dhingra,Jiang-An Yin,Elke Schaper,Berre Doğançay,Marc Emmenegger,Anna Spinelli,Kevin Maggi,Andra Chincisan,Simon Mead,Simone Hornemann,Peter Heutink,Adriano Aguzzi

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

全基因组转录组学鉴定了朊病毒感染的早期临床前特征

Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi

Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line

在低生物危害人类细胞系中模拟朊病毒感染、传播和细胞病理学

Merve Avar, Daniel Heinzer, Nicolas Steinke, Berre Doğançay, Rita Moos, Severine Lugan, Claudia Cosenza, Simone Hornemann, Olivier Andréoletti, Adriano Aguzzi

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier

在具有可渗透血脑屏障的小鼠品系中,朊病毒的致病机制没有改变

Annika Keller, Mario Nuvolone, Irina Abakumova, Andra Chincisan, Regina Reimann, Merve Avar, Daniel Heinzer, Simone Hornemann, Josephin Wagner, Daniel Kirschenbaum, Fabian F Voigt, Caihong Zhu, Luca Regli, Fritjof Helmchen, Adriano Aguzzi