日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evaluation of ASC as a therapeutic target for Alzheimer's disease

评估ASC作为阿尔茨海默病治疗靶点的潜力

Clayton, W Brent; Kulas, Joshua A; Liu, Jiahui; Walia, Nidhi; Rangel-Barajas, Claudia; Johnson, Travis; Zhang, Jie; Huang, Kun; Mesecar, Andrew D; Dage, Jeffrey L; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Next-generation Alzheimer's therapeutics: target assessment and enablement at the Indiana University School of Medicine-Purdue University TREAT-AD Center

下一代阿尔茨海默病疗法:印第安纳大学医学院-普渡大学TREAT-AD中心的靶点评估和开发

Richardson, Timothy I; Klein, Rebecca C; Huang, Kun; Zhang, Jie; Mesecar, Andrew D; Dage, Jeffrey L; Clayton, Brent; Lamb, Bruce T; Palkowitz, Alan D

Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors

光学活性醛和手性氨基茚醇的Ugi多组分反应:与SARS-CoV-2 Mpro抑制剂相关的双酰胺的非对映选择性合成

Ghosh, Arun K; Bhattacharjee, Amlan; Jayashankar, Uttara; Bogan, Sydney N; Mesecar, Andrew D

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.

SHIP1 配体的优化和表征及其在阿尔茨海默病模型中的细胞靶点结合和活性。

Jesudason Cynthia D, Rangel-Barajas Claudia, Beach Colin J, Beck Daniel E, Caballero-Floran Isaac H, Clayton W Brent, Da Silva Lais, David Juliane C, Doolen Suzanne, Faulkner Alexandra N, Hamdani Adam K, Huhe Hasi, Huynh Kevin, Imhoff Ryan D, Javens-Wolfe June, Mason Emily R, Moussaif Mustapha, Singhal Kratika, Soni Disha M, van Buuren-Milne Matilda, Williams Sean-Paul, Angus Steven P, Chu Shaoyou, Dage Jeffrey L, Hipskind Philip A, Johnson Travis S, Kaddurah-Daouk Rima, Lamb Bruce T, Meikle Peter J, Mesecar Andrew D, Palkowitz Alan D, Quinney Sara K, Sukoff Rizzo Stacey J, Oblak Adrian L, Richardson Timothy I

Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration

果蝇Ahcy是一种氧化还原传感器,它通过调节基因表达来保护视网膜免受光应激诱导的退化。

Stanhope, Sarah C; Singhal, Kratika; Morato, Nicolás M; Feng, Yunfei; Meng, Gaoya; Marlin, Makayla N; Kotanko, Claudia C; Jarrett, Madolyn M; Mesecar, Andrew D; Cooks, R Graham; Weake, Vikki M

Identification of PLCγ2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCγ2激活剂

Hawksley, J C; Clayton, Brent; Massey, Steven M; Chu, Shaoyou; Mason, Emily R; Bissel, Stephanie J; Bedford, Logan M; Rizzo, Stacey J Sukoff; Mesecar, Andrew D; Kaiser, Bridget L; Lendy, Emma K; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors

探索尼尔马特雷韦的P1和P4修饰:SARS-CoV-2 Mpro抑制剂的设计、合成、生物学评价和X射线结构研究

Ghosh, Arun K; Yadav, Monika; Iddum, Satyanarayana; Ghazi, Somayeh; Lendy, Emma K; Jayashankar, Uttara; Beechboard, Sydney N; Takamatsu, Yuki; Hattori, Shin-Ichiro; Amano, Masayuki; Higashi-Kuwata, Nobuyo; Mitsuya, Hiroaki; Mesecar, Andrew D

Identification of PLCG2 activators for the treatment of Alzheimer’s disease

鉴定用于治疗阿尔茨海默病的PLCG2激活剂

Dang, Lei; Zhang, Chunbo; Su, Biru; Ning, Na; Huang, Qiuling; Zhou, Su; Wu, Meng; Ma, Wenqing; Wang, Man; Cui, Pengfei; Li, Yan; Wang, Shixuan; Clayton, Brent; Massey, Steven M; Beck, Daniel E; Putt, Karson S; Utsuki, Tada; Visvanathan, Ramya; Mesecar, Andrew D; Lendy, Emma K; Kaiser, Bridget L; Chu, Shaoyou; Mason, Emily R; Lamb, Bruce T; Palkowitz, Alan D; Richardson, Timothy I

pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography

利用pH依赖性反应触发PmHMGR晶体进行时间分辨晶体学研究

Purohit, Vatsal; Steussy, Calvin N; Rosales, Anthony R; Critchelow, Chandra J; Schmidt, Tim; Helquist, Paul; Wiest, Olaf; Mesecar, Andrew; Cohen, Aina E; Stauffacher, Cynthia V

A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes

一种用于定量测定 1-磷脂酰肌醇 4,5-二磷酸磷酸二酯酶 γ (PLCγ) 酶活性的新型细胞内荧光底物

Ramya Visvanathan ,Tadanobu Utsuki ,Daniel E Beck ,W Brent Clayton ,Emma Lendy ,Kuai-Lin Sun ,Yinghui Liu ,Kirk W Hering ,Andrew Mesecar ,Zhong-Yin Zhang ,Karson S Putt