The Impact of Ancestry on Performance of Type 1 Diabetes Genetic Risk Scores: High Discrimination Performance Is Maintained in African Ancestry Populations, but Population-Specific Thresholds May Improve Risk Prediction
祖源对1型糖尿病遗传风险评分性能的影响:在非洲裔人群中保持了较高的区分度,但针对特定人群的阈值可能有助于提高风险预测能力。
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doi:10.2337/dc25-1833
Squires, Steven; Katte, Jean Claude; Dabelea, Dana; Pihoker, Catherine; Divers, Jasmin; Sobngwi, Eugene; Nyirenda, Moffat J; Kreienkamp, Raymond J; Liese, Angela D; Shah, Amy S; Dolan, Lawrence; Reynolds, Kristi; Redondo, Maria J; Hagopian, William; Fatumo, Segun; Dehayem, Mesmin Y; Hattersley, Andrew T; Weedon, Michael N; Jones, Angus; Oram, Richard A