日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I

5,7-二甲氧基色满-3-基 4-甲氧基苯甲酸酯通过肌钙蛋白 I 的磷酸化作用,对突变心肌细丝功能和动力学的调节具有独特的影响

Yang, Zeyu; Sheehan, Alice M; Papadaki, Mary; Messer, Andrew E; Blagg, Brian S J; Gould, Ian R; Marston, Steven B

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

营养保健品水飞蓟宾B、白藜芦醇和表没食子儿茶素-3-没食子酸酯与心肌肌钙蛋白结合,可在体外、体内和计算机模拟中恢复由心肌病突变引起的舒张功能丧失。

Yang, Zeyu; Sheehan, Alice M; Messer, Andrew E; Tsui, Sharmane; Sparrow, Alexander; Redwood, Charles; Kren, Vladimir; Gould, Ian R; Marston, Steven B

Investigations into the Sarcomeric Protein and Ca(2+)-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

对猫(Felix catus)肥厚型心肌病肌节蛋白和 Ca(2+) 调节异常的研究

Messer Andrew E, Chan Jasmine, Daley Alex, Copeland O'Neal, Marston Steven B, Connolly David J

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.

与肥厚型心肌病相关的肌钙蛋白 T 突变会增加 Ca(2+) 敏感性,并抑制肌钙蛋白 I 磷酸化对 Ca(2+) 敏感性的调节

Messer Andrew E, Bayliss Christopher R, El-Mezgueldi Mohammed, Redwood Charles S, Ward Douglas G, Leung Man-Ching, Papadaki Maria, Dos Remedios Cristobal, Marston Steven B

Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function

ACTA1基因中的H40Y突变会导致肌病,并损害肌动蛋白丝的结构和功能。

Chan, Chun; Fan, Jun; Messer, Andrew E; Marston, Steve B; Iwamoto, Hiroyuki; Ochala, Julien

Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.

肌丝 Ca2+ 敏感性与肌钙蛋白 I 磷酸化之间的突变解偶联可通过表没食子儿茶素-3-没食子酸酯逆转

Papadaki Maria, Vikhorev Petr G, Marston Steven B, Messer Andrew E

The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I

导致扩张型心肌病的ACTC E361G突变存在于心肌肌原纤维中,特异性地消除了肌钙蛋白I磷酸化对Ca(2+)调节的调控作用。

Vikhorev, Petr G; Song, Weihua; Wilkinson, Ross; Copeland, O'Neal; Messer, Andrew E; Ferenczi, Michael A; Marston, Steven B

The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy

与肥厚型梗阻性心肌病相关的人类心肌肌球蛋白分子表型

Jacques, Adam M; Briceno, Natalia; Messer, Andrew E; Gallon, Clare E; Jalilzadeh, Shapour; Garcia, Edwin; Kikonda-Kanda, Gaelle; Goddard, Jennifer; Harding, Sian E; Watkins, Hugh; Esteban, M Tomé; Tsang, Victor T; McKenna, William J; Marston, Steven B