日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer

发现和开发高效且选择性的双重NUAK/MARK抑制剂,作为Hippo通路调节剂用于癌症治疗

Smil, David; Liu, Yong; Xin, Tao; Kiyota, Taira; Aman, Ahmed; Grouleff, Julie; Hoffer, Laurent; Joshi, Dhananjay C; Inanlou, Mohammad R; Song, Siyuan; Mao, Daniel Y L; Ogunjimi, Abiodun A; Pau, Victor; Chini, Fiona D; Kurinov, Igor; Zhang, Ying; Nguyen, Anh Thu; Wrana, Jeffrey L; Sicheri, Frank; Attisano, Liliana; Uehling, David; Al-Awar, Rima; Isaac, Methvin B

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

伊米吡酮 ONC213 靶向 α-酮戊二酸脱氢酶,诱导线粒体应激并抑制急性髓系白血病中的氧化磷酸化

Yongwei Su ,Jenna L Carter ,Xinyu Li ,Yu Fukuda ,Ashley Gray ,John Lynch ,Holly Edwards ,Jun Ma ,Patrick Schreiner ,Lisa Polin ,Juiwanna Kushner ,Sijana H Dzinic ,Steven A Buck ,Shondra M Pruett-Miller ,Katie Hege-Hurrish ,Camenzind Robinson ,Xinan Qiao ,Shuang Liu ,Shuangshuang Wu ,Guan Wang ,Jing Li ,Joshua E Allen ,Varun V Prabhu ,Aaron D Schimmer ,Dhananjay Joshi ,Shiva Kalhor-Monfared ,Iain D G Watson ,Richard Marcellus ,Methvin B Isaac ,Rima Al-Awar ,Jeffrey W Taub ,Hai Lin ,John D Schuetz ,Yubin Ge

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

发现两种针对激活素受体样激酶 1 和 2 的高选择性结构正交化学探针

Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Be

Discovery of Conformationally Constrained ALK2 Inhibitors

构象受限的ALK2抑制剂的发现

González-Álvarez, Héctor; Ensan, Deeba; Xin, Tao; Wong, Jong Fu; Zepeda-Velázquez, Carlos A; Cros, Julien; Sweeney, Melissa N; Hoffer, Laurent; Kiyota, Taira; Wilson, Brian J; Aman, Ahmed; Roberts, Owen; Isaac, Methvin B; Bullock, Alex N; Smil, David; Al-Awar, Rima

Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor

OICR12694 的发现:一种新型、高效、选择性强且口服生物利用度高的 BCL6 BTB 抑制剂

Mamai, Ahmed; Chau, Anh M; Wilson, Brian J; Watson, Iain D; Joseph, Babu B; Subramanian, Pandiaraju R; Morshed, Monzur M; Morin, Justin A; Prakesch, Michael A; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A; Pomroy, Neil C; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E; Al-Awar, Rima; Privé, Gilbert G; Isaac, Methvin B

Opposing forces of cardiogenic shock: left ventricular outflow obstruction, severe mitral regurgitation, and left ventricular dysfunction in Takotsubo cardiomyopathy

心源性休克的对抗因素:Takotsubo心肌病中的左心室流出道梗阻、严重二尖瓣反流和左心室功能障碍

Methvin, Laura; Liu, Spencer D; Dodge, Shayne E; Gilstrap, Lauren G

Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of (11)C-Labeled ALK2 Inhibitors

利用开放科学进行PET药物开发:(11)C标记的ALK2抑制剂的初步神经影像学研究

Murrell, Emily; Tong, Junchao; Smil, David; Kiyota, Taira; Aman, Ahmed M; Isaac, Methvin B; Watson, Iain D G; Vasdev, Neil

The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia

PKN1-TRAF1信号轴作为慢性淋巴细胞白血病的潜在新靶点

Maria I Edilova, Jaclyn C Law, Safoura Zangiabadi, Kenneth Ting, Achire N Mbanwi, Andrea Arruda, David Uehling, Methvin Isaac, Michael Prakesch, Rima Al-Awar, Mark D Minden, Ali A Abdul-Sater, Tania H Watts

Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

靶向ALK2:采用开放科学方法开发治疗弥漫性内生性脑桥胶质瘤的疗法

Ensan, Deeba; Smil, David; Zepeda-Velázquez, Carlos A; Panagopoulos, Dimitrios; Wong, Jong Fu; Williams, Eleanor P; Adamson, Roslin; Bullock, Alex N; Kiyota, Taira; Aman, Ahmed; Roberts, Owen G; Edwards, Aled M; O'Meara, Jeff A; Isaac, Methvin B; Al-Awar, Rima

Sorafenib as an Inhibitor of RUVBL2

索拉非尼作为RUVBL2抑制剂

Nano, Nardin; Ugwu, Francisca; Seraphim, Thiago V; Li, Tangzhi; Azer, Gina; Isaac, Methvin; Prakesch, Michael; Barbosa, Leandro R S; Ramos, Carlos H I; Datti, Alessandro; Houry, Walid A