日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models

比率激活型细胞穿透肽可标记胰腺癌,从而实现荧光引导手术,降低原位小鼠模型中的转移和复发率。

Metildi, Cristina A; Felsen, Csilla N; Savariar, Elamprakash N; Nguyen, Quyen T; Kaushal, Sharmeela; Hoffman, Robert M; Tsien, Roger Y; Bouvet, Michael

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer

hypusine-eIF5A-PEAK1开关调控胰腺癌的发病机制

Ken Fujimura, Tracy Wright, Jan Strnadel, Sharmeela Kaushal, Cristina Metildi, Andrew M Lowy, Michael Bouvet, Jonathan A Kelber, Richard L Klemke

Fluorescence-guided surgery with a fluorophore-conjugated antibody to carcinoembryonic antigen (CEA), that highlights the tumor, improves surgical resection and increases survival in orthotopic mouse models of human pancreatic cancer

利用荧光标记的癌胚抗原 (CEA) 抗体进行荧光引导手术,可突出显示肿瘤,从而提高手术切除率,并延长人胰腺癌原位小鼠模型的生存期。

Metildi, Cristina A; Kaushal, Sharmeela; Pu, Minya; Messer, Karen A; Luiken, George A; Moossa, Abdool R; Hoffman, Robert M; Bouvet, Michael

Advantages of fluorescence-guided laparoscopic surgery of pancreatic cancer labeled with fluorescent anti-carcinoembryonic antigen antibodies in an orthotopic mouse model

在原位小鼠模型中,荧光引导腹腔镜手术治疗荧光标记抗癌胚抗原抗体标记的胰腺癌的优势

Metildi, Cristina A; Kaushal, Sharmeela; Luiken, George A; Hoffman, Robert M; Bouvet, Michael

Fluorescently labeled chimeric anti-CEA antibody improves detection and resection of human colon cancer in a patient-derived orthotopic xenograft (PDOX) nude mouse model

荧光标记的嵌合抗CEA抗体可提高患者来源原位异种移植(PDOX)裸鼠模型中人结肠癌的检测和切除率。

Metildi, Cristina A; Kaushal, Sharmeela; Luiken, George A; Talamini, Mark A; Hoffman, Robert M; Bouvet, Michael

In vivo fluorescence imaging of gastrointestinal stromal tumors using fluorophore-conjugated anti-KIT antibody

使用荧光团偶联的抗 KIT 抗体对胃肠道间质瘤进行体内荧光成像

Cristina A Metildi, Chih-Min Tang, Sharmeela Kaushal, Stephanie Y Leonard, Paolo Magistri, Hop S Tran Cao, Robert M Hoffman, Michael Bouvet, Jason K Sicklick

In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status

在原位小鼠模型中对人胰腺癌细胞进行体内连续选择,可产生高转移性变异株,且与Kras状态无关。

Metildi, Cristina A; Kaushal, Sharmeela; Hoffman, Robert M; Bouvet, Michael

Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model

荧光引导下的人结肠癌手术可提高肿瘤完全切除率,从而在原位裸鼠模型中实现治愈。

Metildi, Cristina A; Kaushal, Sharmeela; Snyder, Cynthia S; Hoffman, Robert M; Bouvet, Michael

Fluorescence-guided surgery and fluorescence laparoscopy for gastrointestinal cancers in clinically-relevant mouse models

在具有临床意义的小鼠模型中,荧光引导手术和荧光腹腔镜技术用于治疗胃肠道癌症

Metildi, Cristina A; Hoffman, Robert M; Bouvet, Michael

KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer

KRas诱导Src/PEAK1/ErbB2激酶扩增环路,从而驱动胰腺癌的转移性生长和治疗耐药性。

Kelber, Jonathan A; Reno, Theresa; Kaushal, Sharmeela; Metildi, Cristina; Wright, Tracy; Stoletov, Konstantin; Weems, Jessica M; Park, Frederick D; Mose, Evangeline; Wang, Yingchun; Hoffman, Robert M; Lowy, Andrew M; Bouvet, Michael; Klemke, Richard L